Heavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1144 - 1144

Published: July 3, 2024

Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative characterized by involuntary movements, cognitive decline, executive dysfunction, neuropsychiatric conditions such as anxiety depression. It follows an autosomal dominant inheritance pattern. Thus, child who has parent with the mutated huntingtin (mHTT) gene 50% chance of developing disease. Since HTT protein involved in many critical cellular processes, including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, autophagy, its aberrant aggregates lead to disruption numerous pathways neurodegeneration. Essential heavy metals are vital at low concentrations; however, higher concentrations, they can exacerbate HD disrupting glial–neuronal communication and/or causing dysbiosis (disturbance gut microbiota, GM), both which neuroinflammation further Here, we discuss detail interactions iron, manganese, copper glial–neuron GM indicate how this knowledge may pave way for development new generation disease-modifying therapies HD.

Language: Английский

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Short-chain fatty acids in Huntington's disease: Mechanisms of action and their therapeutic implications

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: unknown, P. 173972 - 173972

Published: Feb. 1, 2025

Language: Английский

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Roles of microbiota in autoimmunity in Arabidopsis leaves

Nature Plants, Journal Year: 2024, Volume and Issue: 10(9), P. 1363 - 1376

Published: Sept. 6, 2024

Over the past three decades, researchers have isolated plant mutants that show constitutively activated defence responses in absence of pathogen infection. These are called autoimmune and typically dwarf and/or bearing chlorotic/necrotic lesions. Here, from a genetic screen for Arabidopsis genes involved maintaining normal leaf microbiota, we identified TIP GROWTH DEFECTIVE 1 (TIP1), which encodes an S-acyltransferase, as key player guarding leaves against abnormal microbiota level composition under high-humidity conditions. The tip1 mutant has several characteristic phenotypes classical mutants, including stature, showing lesions, having high basal gene expression. Gnotobiotic experiments revealed largely dependent on presence axenic plants markedly reduced phenotypes. We found dependency is shared by 'lesion mimic'-type Arabidopsis. It worth noting caused mutations two Nucleotide-Binding, Leucine-Rich Repeat (NLR) do not require can even be partially alleviated microbiota. Our results therefore suggest existence at least classes autoimmunity (microbiota-dependent versus microbiota-independent) plants. observed interplay between lesion mimic class reminiscent interactions dysbiosis animal kingdom. parallels highlight intricate relationship host immunity microbial communities across various biological systems.

Language: Английский

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Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Published: June 12, 2024

Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative characterized by involuntary movements, cognitive decline, executive dysfunction, neuropsychiatric conditions such as anxiety depression. It follows an autosomal dominant inheritance pattern. Thus, child who has parent with the mutated huntingtin (mHTT) gene 50% chance of developing disease. Since HTT protein involved in many critical cellular processes including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, autophagy, its aberrant aggregates lead to disruption numerous pathways neurodegeneration. Essential heavy metals are vital at low concentrations, however, higher can exacerbate HD disrupting glial-neuronal communication, and/or causing dysbiosis (disturbance gut microbiota, GM), both which neuroinflammation further Here, we discuss detail interactions iron, manganese copper glial-neuron communication GM indicate how this knowledge may pave way for development new generation disease-modifying therapies HD.

Language: Английский

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Deciphering the Microbial Map and its implications in the therapeutics of Neurodegenerative Disorder

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102466 - 102466

Published: Aug. 27, 2024

Language: Английский

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Role of oral-gut-brain axis in psychiatric and neurological disorders

Shijie huaren xiaohua zazhi, Journal Year: 2024, Volume and Issue: 32(12), P. 878 - 886

Published: Dec. 28, 2024

Language: Английский

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