A longitudinal study on SARS-CoV-2 seroconversion, reinfection and neutralisation spanning several variant waves and vaccination campaigns, Heinsberg, Germany, April 2020 to November 2022 DOI Creative Commons
Bianca Schulte,

Enrico Richter,

Antonia Büning

et al.

Eurosurveillance, Journal Year: 2024, Volume and Issue: 29(26)

Published: June 27, 2024

BackgroundSince its emergence in December 2019, over 700 million people worldwide have been infected with SARS-CoV-2 up to May 2024. While early rollout of mRNA vaccines against COVID-19 has saved many lives, there was increasing immune escape new virus variants. Longitudinal monitoring population-wide antibody responses from regular sample collection irrespective symptoms provides representative data on infection and seroconversion/seroreversion rates.AimTo examine adaptive cellular a German outbreak cohort through several waves different variants.MethodsUtilising 31-month longitudinal seroepidemiological study (n = 1,446; mean age: 50 years, range: 2-103) initiated during the first superspreading event (February 2020) Heinsberg, Germany, we analysed acute infection, seroconversion neutralisation at five follow-up visits between October 2020 November 2022; cross-protective immunity Omicron variants were also examined.ResultsSARS-CoV-2 spike (S)-specific IgAs decreased shortly after while IgGs remained stable. Both increased significantly vaccination. We predict an 18-month half-life S upon infection. Nucleocapsid (N)-specific declined 12 months post-infection but (p < 0.0001) Omicron. Frequencies SARS-CoV-2-specific TNF-alpha+/IFN-gamma+ CD4+ T-cells 0.01). antibodies titres highest triple-vaccinated participants April 2021 2022 compared infections January 2021. Cross BQ.1.18 XBB.1.5 very low all groups.ConclusionInfection and/or vaccination did not provide population cross-protection

Language: Английский

Vergleich zwischen COVID-19-bedingten und anderen natürlichen Todesfällen während der ersten fünf Pandemiewellen DOI Creative Commons

Andrea Buschner,

Katharina Katz,

Andreas Beyerlein

et al.

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, Journal Year: 2024, Volume and Issue: 67(8), P. 939 - 946

Published: July 16, 2024

Older age is a risk factor for fatal course of SARS-CoV‑2 infection, possibly due to comorbidities whose exact role in this context, however, not yet well understood. In paper, the characteristics and persons who had died COVID-19 Bavaria by July 2022 are shown compared with other fatalities during pandemic.

Language: Английский

Citations

3
Long-term trends in the protection against severe courses of COVID-19 by vaccination DOI
Andreas Beyerlein, Maximilian Weigert,

Katharina Katz

et al.

Deutsches Ärzteblatt international, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 17, 2023

The long-term course of protection against severe COVID-19 courses by vaccine-induced or hybrid immunity in Germany is unclear.

Language: Английский

Citations

2
No increased rates of COVID-19 breakthrough infections in Altötting, a Bavarian district with a history of environmental PFOA contamination—results from a retrospective observational study DOI Creative Commons
Andreas Beyerlein, Stefanie Heinze, Caroline Quartucci

et al.

Infection, Journal Year: 2024, Volume and Issue: 52(4), P. 1639 - 1642

Published: March 13, 2024

Language: Английский

Citations

0
A longitudinal study on SARS-CoV-2 seroconversion, reinfection and neutralisation spanning several variant waves and vaccination campaigns, Heinsberg, Germany, April 2020 to November 2022 DOI Creative Commons
Bianca Schulte,

Enrico Richter,

Antonia Büning

et al.

Eurosurveillance, Journal Year: 2024, Volume and Issue: 29(26)

Published: June 27, 2024

BackgroundSince its emergence in December 2019, over 700 million people worldwide have been infected with SARS-CoV-2 up to May 2024. While early rollout of mRNA vaccines against COVID-19 has saved many lives, there was increasing immune escape new virus variants. Longitudinal monitoring population-wide antibody responses from regular sample collection irrespective symptoms provides representative data on infection and seroconversion/seroreversion rates.AimTo examine adaptive cellular a German outbreak cohort through several waves different variants.MethodsUtilising 31-month longitudinal seroepidemiological study (n = 1,446; mean age: 50 years, range: 2-103) initiated during the first superspreading event (February 2020) Heinsberg, Germany, we analysed acute infection, seroconversion neutralisation at five follow-up visits between October 2020 November 2022; cross-protective immunity Omicron variants were also examined.ResultsSARS-CoV-2 spike (S)-specific IgAs decreased shortly after while IgGs remained stable. Both increased significantly vaccination. We predict an 18-month half-life S upon infection. Nucleocapsid (N)-specific declined 12 months post-infection but (p < 0.0001) Omicron. Frequencies SARS-CoV-2-specific TNF-alpha+/IFN-gamma+ CD4+ T-cells 0.01). antibodies titres highest triple-vaccinated participants April 2021 2022 compared infections January 2021. Cross BQ.1.18 XBB.1.5 very low all groups.ConclusionInfection and/or vaccination did not provide population cross-protection

Language: Английский

Citations

0