Oncoviral Infections and Small Extracellular Vesicles DOI Creative Commons

Łukasz Ważny,

Theresa L. Whiteside, Monika Pietrowska

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1291 - 1291

Published: Aug. 13, 2024

Small extracellular vesicles (sEV) are small membrane-bound nanovesicles with a size range below 200 nm that released by all types of cells. sEV carry diverse cargo proteins, lipids, glycans, and nucleic acids mimic the content producer mediate intercellular communication play key role in broad variety physiological pathological conditions. Recently, numerous reports have emerged examining viral infections. A significant number similarities biogenesis pathways replication cycles viruses suggest might influence course infections ways. Besides directly modulating virus propagation transporting (complete virions, RNA, DNA), can also modify host antiviral response increase susceptibility cells to infection. The network mutual interactions is particularly complex case oncogenic viruses, deserving special consideration because its significance cancer progression. This review summarizes current knowledge between focusing on abilities modulate carcinogenic properties oncoviruses.

Language: Английский

Unveiling therapeutic potential: Adipose tissue-derived mesenchymal stem cells and their exosomes in the management of diabetes mellitus, wound healing, and chronic ulcers DOI

Amirhossein Ahmadieh-Yazdi,

Mahdieh Karimi,

Elham Afkhami

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 226, P. 116399 - 116399

Published: June 27, 2024

Language: Английский

Citations

9
Plant Growth Promotion and Plant Disease Suppression Induced by Bacillus amyloliquefaciens Strain GD4a DOI Creative Commons

Piao Yang,

Yuan Pu, Wen‐Shan Liu

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(5), P. 672 - 672

Published: Feb. 28, 2024

Botrytis cinerea, the causative agent of gray mold disease (GMD), invades plants to obtain nutrients and disseminates through airborne conidia in nature. Bacillus amyloliquefaciens strain GD4a, a beneficial bacterium isolated from switchgrass, shows great potential managing GMD plants. However, precise mechanism by which GD4a confers benefits remains elusive. In this study, an A. thaliana-B. cinerea-B. multiple-scale interaction model was used explore how bacteria play essential roles plant growth promotion, pathogen suppression, immunity boosting. Arabidopsis Col-0 wild-type served as testing ground assess GD4a’s efficacy. Additionally, bacterial enzyme activity targeted metabolite tests were conducted validate for enhancing suppressing pathogens diseases. subjected co-incubation with various bacterial, fungal, oomycete evaluate its antagonistic effectiveness vitro. vivo inoculation assays also carried out investigate role regulating host immunity. Bacterial extracellular exudate (BEE) extracted, purified, untargeted metabolomics analysis. Benzocaine (BEN) analysis selected further study function related mechanisms mutant qRT-PCR Finally, comprehensive formulated summarize applying agricultural systems. Our demonstrates efficacy growth, diseases, bolstering Importantly, produces functional that significantly disrupts pathogenicity B. cinerea inhibiting fungal conidium germination hypha formation. our identifies benzocaine novel small molecule triggers basal defense, ISR, SAR responses can effectively promote suppress disease, boost BEE production diverse gene expression.

Language: Английский

Citations

8
Extracellular Vesicles in Cancer Immunotherapy: Therapeutic, Challenges and Clinical Progress DOI Creative Commons
Hamed Manoochehri,

Anita Silas La’ah,

Ali Babaeizad

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101065 - 101065

Published: May 1, 2025

Language: Английский

Citations

0
Oncoviral Infections and Small Extracellular Vesicles DOI Creative Commons

Łukasz Ważny,

Theresa L. Whiteside, Monika Pietrowska

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1291 - 1291

Published: Aug. 13, 2024

Small extracellular vesicles (sEV) are small membrane-bound nanovesicles with a size range below 200 nm that released by all types of cells. sEV carry diverse cargo proteins, lipids, glycans, and nucleic acids mimic the content producer mediate intercellular communication play key role in broad variety physiological pathological conditions. Recently, numerous reports have emerged examining viral infections. A significant number similarities biogenesis pathways replication cycles viruses suggest might influence course infections ways. Besides directly modulating virus propagation transporting (complete virions, RNA, DNA), can also modify host antiviral response increase susceptibility cells to infection. The network mutual interactions is particularly complex case oncogenic viruses, deserving special consideration because its significance cancer progression. This review summarizes current knowledge between focusing on abilities modulate carcinogenic properties oncoviruses.

Language: Английский

Citations

2