International Journal of Cancer,
Journal Year:
2019,
Volume and Issue:
145(3), P. 775 - 784
Published: Jan. 24, 2019
Over
the
past
decade,
there
has
been
a
change
in
epidemiology
of
oral
cavity
squamous
cell
cancer
(OC‐SCC).
Many
new
cases
OC‐SCC
lack
recognized
risk
factors
smoking,
alcohol
and
human
papilloma
virus.
The
aim
this
study
was
to
determine
if
microbiome
may
be
associated
with
nonsmoking
HPV
negative
patients.
We
compared
HPV‐negative
nonsmoker
OC‐SCC(n
=
18),
premalignant
lesions(PML)
(n
8)
normal
control
patients
12).
Their
sampled
by
wash
defined
16S
rRNA
gene
sequencing.
report
that
periodontal
pathogens
Fusobacterium,
Prevotella,
Alloprevotella
were
enriched
while
commensal
Streptococcus
depleted
OC‐SCC.
Based
on
four
genera
plus
marker
genus
Veillonella
for
PML,
we
classified
into
two
types.
Gene/pathway
analysis
revealed
progressive
increase
genes
encoding
HSP90
ligands
TLRs
1,
2
4
along
controls→PML
→
progression
sequence.
Our
findings
suggest
an
association
between
non
smoking
Biomedicine & Pharmacotherapy,
Journal Year:
2019,
Volume and Issue:
121, P. 109604 - 109604
Published: Nov. 13, 2019
Quercetin
is
a
kind
of
flavonoid
compounds
that
comes
from
nature
and
widely
existed
in
the
daily
diet.
Previous
studies
have
found
quercetin
has
many
effects
such
as
anti-inflammatory,
anti-oxidation
anti-cancer.
Both
vivo
vitro
experiments
demonstrated
can
exert
anti-tumor
by
altering
cell
cycle
progression,
inhibiting
proliferation,
promoting
apoptosis,
angiogenesis
metastasis
affecting
autophagy.
This
review
summarizes
evidence
for
pharmacological
potential
inhibition
on
cancers,
supporting
viewpoint
should
be
adequately
considered
therapeutic
agent
against
various
cancers.
Cancers,
Journal Year:
2019,
Volume and Issue:
11(1), P. 38 - 38
Published: Jan. 3, 2019
Cancer
is
a
multifactorial
pathology
and
it
represents
the
second
leading
cause
of
death
worldwide.
In
recent
years,
numerous
studies
highlighted
dual
role
gut
microbiota
in
preserving
host’s
health.
Gut
resident
bacteria
are
able
to
produce
number
metabolites
bioproducts
necessary
protect
gut’s
homeostasis.
Conversely,
several
subpopulations
may
expand
during
pathological
dysbiosis
therefore
high
levels
toxins
capable,
turn,
trigger
both
inflammation
tumorigenesis.
Importantly,
can
interact
with
host
either
modulating
directly
epithelium
or
immune
system.
Numerous
populating
bacteria,
called
probiotics,
have
been
identified
as
protective
against
genesis
tumors.
Given
their
capability
homeostasis,
probiotics
currently
tested
help
fight
cancer
patients
subjected
chemotherapy
radiotherapy.
Most
recently,
three
independent
show
that
specific
species
potentiate
positive
outcome
anti-cancer
immunotherapy.
The
highly
significant
studies,
uncovering
tight
association
between
tumorigenesis,
well
therapy,
here
described.
Lactobacillus
rhamnosus
GG
(LGG),
most
studied
probiotic
model
cancer,
also
reported.
Overall,
according
findings
summarized,
novel
strategies
integrating
such
LGG,
conventional
therapies
strongly
encouraged.
Computational and Structural Biotechnology Journal,
Journal Year:
2021,
Volume and Issue:
19, P. 1335 - 1360
Published: Jan. 1, 2021
The
oralome
is
the
summary
of
dynamic
interactions
orchestrated
between
ecological
community
oral
microorganisms
(comprised
up
to
approximately
1000
species
bacteria,
fungi,
viruses,
archaea
and
protozoa
-
microbiome)
that
live
in
cavity
host.
These
form
a
complex
ecosystem
thrive
environment
symbiotic
relationship
with
human
However,
microbial
composition
significantly
affected
by
interspecies
host-microbial
interactions,
which
turn,
can
impact
health
disease
status
In
this
review,
we
discuss
inter-species
take
place
examine
how
these
change
from
healthy
(eubiotic)
(dysbiotic)
states.
We
further
dysbiotic
signatures
associated
periodontitis
caries
their
sequalae,
(e.g.,
tooth/bone
loss
pulpitis),
systemic
diseases
diseases,
such
as
infective
endocarditis,
atherosclerosis,
diabetes,
Alzheimer's
head
neck/oral
cancer.
then
current
computational
techniques
assess
microbiome
changes.
Lastly,
novel
for
modulation
may
help
prevention
treatment,
including
standard
hygiene
methods,
prebiotics,
probiotics,
use
nano-sized
drug
delivery
systems
(nano-DDS),
extracellular
polymeric
matrix
(EPM)
disruption,
host
response
modulators.
Cancer Medicine,
Journal Year:
2019,
Volume and Issue:
8(6), P. 3167 - 3181
Published: April 5, 2019
Successful
treatment
of
cancer
remains
a
challenge,
due
to
the
unique
pathophysiology
solid
tumors,
and
predictable
emergence
resistance.
Traditional
methods
for
therapy
including
radiotherapy,
chemotherapy,
immunotherapy
all
have
their
own
limitations.
A
novel
approach
is
bacteriotherapy,
either
used
alone,
or
in
combination
with
conventional
methods,
has
shown
positive
effect
on
regression
tumors
inhibition
metastasis.
Bacteria-assisted
tumor-targeted
as
therapeutic/gene/drug
delivery
vehicles
great
promise
tumors.
The
use
bacteria
only,
was
found
be
effective
some
experimental
models
(tumor
increased
survival
rate).
In
this
article,
we
reviewed
major
advantages,
challenges,
prospective
directions
combinations
tumor
therapy.
