Multiplicity of benign breast disease lesions and breast cancer risk in African American women DOI Creative Commons
Vidya Patil, Julie J. Ruterbusch, Wei Chen

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 16, 2024

The risk of developing subsequent breast cancer is higher in women diagnosed with benign disease (BBD) but these studies were primarily performed non-Hispanic white populations. Still, estimates have been used to inform models that are being clinically across all racial and ethnic groups. Given the high mortality rates among African American (AA) women, it critical study BBD this population, ensure include information perform adequately. This utilized data from AA who underwent biopsies at a hospital served by University Pathology Group Detroit, Michigan, 1998 2010. Patients followed for cancers through population-based Metropolitan Detroit Cancer Surveillance System (MDCSS). lesion scores assigned represent severity or extent lesions, indicating greater number distinct types. Of 3,461 eligible cohort, 6.88% (n=238) subsequently developed cancer. Examined individually, six eleven lesions (apocrine metaplasia, ductal hyperplasia, lobular intraductal papilloma, sclerosing adenosis, columnar alterations radial scars) significantly associated increased after adjustment age year biopsy further considered multiple models. For every different type lesion, 25% (RR=1.25, 95% CI: 1.10, 1.42) proliferative versus non-proliferative disease. In summary, affirms BBD, particularly those lesions. These findings implications management millions affected group could benefit personalized surveillance reduction strategies.

Language: Английский

AACR Cancer Disparities Progress Report 2024: Achieving the Bold Vision of Health Equity DOI Open Access
Patrick A. Williams, Sayyed K. Zaidi, Haleh Ramian

et al.

Cancer Epidemiology Biomarkers & Prevention, Journal Year: 2024, Volume and Issue: 33(7), P. 870 - 873

Published: May 15, 2024

Advances in cancer prevention, early detection, and treatments have led to unprecedented progress against cancer. However, these advances not benefited everyone equally. Because of a long history structural inequities systemic injustices the United States, many segments US population continue shoulder disproportionate burden The American Association for Cancer Research (AACR) Disparities Progress Report 2024 (CancerDisparitiesProgressReport.org) outlines recent disparities, ongoing challenges faced by medically underserved populations, emphasizes vital need further research patient care benefit all populations.

Language: Английский

Citations

11
Cancer therapy and reproductive impact DOI Creative Commons
Dov Feldberg,

Nikhil Purandare

International Journal of Gynecology & Obstetrics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract All patients where the cancer treatment has gonadotoxic potential should be referred for oncofertility advice. The effect of chemotherapy and radiotherapy on human ovary can vary from no impact to full‐blown premature ovarian failure due hormonal follicular depletion. Total contraindications fertility cryopreservation include acute malignancy that requires immediate lifesaving therapy. In prepubertal girls, only option urgent preservation is tissue cryopreservation. Prepubertal testicular experimental.

Language: Английский

Citations

1
Innovative landscapes in intraperitoneal therapy of ovarian cancer DOI
K. Kumar,

M. S. Madhusoodanan,

Meghna Pangath

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

1
Averted lung cancer deaths due to reductions in cigarette smoking in the United States, 1970–2022 DOI Open Access
Farhad Islami, Nigar Nargis, Qinran Liu

et al.

CA A Cancer Journal for Clinicians, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Lung cancer mortality rates in the United States have declined steeply recent decades, largely because of substantial reductions smoking prevalence, as approximately 85% lung deaths are attributable to cigarette smoking. In this study, authors estimate number averted and corresponding person-years life gained during 1970-2022 a measure progress prevention through tobacco control. By using National Center for Health Statistics data (with national coverage), calculated expected each year, age, sex, race, age group based on death rate multiplied by population at risk that group. The were subtracting observed from Person-years estimated avoided premature average additional years person would lived if they had not died cancer. 3,856,240 (2,246,610 men, 1,609,630 women) averted, 76,275,550 (40,277,690 35,997,860 1970-2022, with an 19.8 (17.9 22.4 per death. accounted 51.4% declines overall was substantially greater men (60.1%) than women (42.7%). proportion 53.6% White (62.8% 44.6% 40.0% Black (44.4% 34.7% women). numbers highlight remarkable effect against reducing

Language: Английский

Citations

1
Epidemiological trends in gastrointestinal cancers and risk factors across U.S. states from 2000 to 2021: a systematic analysis for the global burden of disease study 2021 DOI Creative Commons
Jiahao Jiang, Zhiqin Xie, Qingbin Wang

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 6, 2025

Gastrointestinal (GI) cancers account for over a quarter of all cancer-related deaths in the United States; however, latest trends their prevalence remain unclear. Data on GI were obtained from Global Burden Disease Study 2021. Age-standardized incidence rates (ASIR) and age-standardized mortality (ASMR) estimated across various states, sexes, ages, risk factors, annual percentage changes calculated. From 2000 to 2021, liver cancer exhibited greatest increase both ASIR ASMR, followed by pancreatic cancer. In contrast, stomach showed decline, colorectal cancer, esophageal biliary tract Most predominantly affect men tend toward younger age onset. Geographic disparities exist burden factors. For esophageal, stomach, cancers, linked diet smoking decreased, whereas alcohol-related increased several especially West Virginia. Hepatitis C remains leading cause with intravenous drug use as primary factor. Non-alcoholic steatohepatitis (NASH) is fastest-growing excessive alcohol use. Mortality due high body-mass index fasting plasma glucose have states groups. The epidemiological U.S. shifted substantially. States need implement targeted policies that address specific populations factors each type.

Language: Английский

Citations

0
Ultra-Sensitive Gaseous Styrene and Isoprene Detection with a Ratiometric Fluorescence Probe of Eu(III)-Incorporated UiO-67 DOI
Rui Cao, Xinxin Li,

Zhihang He

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

The development of probes for the efficient detection volatile organic compounds is crucial both human health protection and environmental monitoring. In this study, we successfully synthesized a ratiometric fluorescent sensing material [Eu-UiO-67 (1:1)], featuring dual-emission fluorescence peaks via one-pot method. This demonstrated exceptional recognition properties liquid styrene isoprene, achieving low limit detections (LODs) 6.2 20.24 ppb, respectively. Furthermore, leveraged its outstanding photoluminescence to fabricate Eu-UiO-67 film, which exhibited distinctive responses toward gaseous isoprene. unique behavior resulted in LODs 12.42 ppb 15.39 investigation into mechanisms revealed that response was mediated by an internal filtration effect, arose from competitive energy absorption between (1:1) material. contrast, resonance transfer occurred isoprene materials. approach offers sensitive reliable method liquid/gaseous

Language: Английский

Citations

0
Assessment of Knowledge, Attitude and Practice among Nurses Regarding Safe Administration of Chemotherapy at Tertiary Care Hospitals of Peshawar DOI Creative Commons
Ashfaq Ahmad,

Abdullah Abdullah,

M. Ziad

et al.

Pakistan BioMedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 11 - 17

Published: Jan. 31, 2025

It is well known that many anti-cancer medications can cause teratology and mutation in humans. The primary groups exposed to these drugs a hospital setting are nurses. Typically, handling patient waste, administering preparing antineoplastic agents, cleaning up chemotherapy spills the jobs carry highest risk of exposure. Objectives: To assess nurses' attitudes, practices, Knowledge related safe administration cytotoxic drugs. Methods: Descriptive inferential statistics were used analyze data collected from 51 nurses who participated descriptive cross-sectional study conducted at Peshawar public sector hospitals. was using structured questionnaire Universal sampling technique. Results: result shows 49.0 % total have excellent Knowledge, 41.2% good regarding 29.4% practice. In comparison, 70.6% poor Most positive attitude towards safely Conclusions: concluded this comes following conclusion after thorough analysis review patients. majority samples had practice for giving As result, it's essential increase workplace safety, provide protective gear, create best practices oncology

Language: Английский

Citations

0
Interpretable Machine Learning for Survival Prediction and Analysis in Stage Ib Lung Squamous Cell Carcinoma DOI
Qi Ding, Chutong Lin,

Y. H. Lam

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Rapid in situ mutation detection in extracellular vesicle DNA DOI Open Access
Md. Mofizur Rahman, Lixue Wang,

Yundi Chen

et al.

Extracellular Vesicles and Circulating Nucleic Acids, Journal Year: 2025, Volume and Issue: 6(1), P. 72 - 86

Published: Feb. 17, 2025

Aim: A PCR- and sequencing-free mutation detection assay facilitates cancer diagnosis reduces over-reliance on specialized equipment. This benefit was highlighted during the pandemic when high demand for viral nucleic acid testing often sidelined analysis. shift led to substantial challenges patients targeted therapy in tracking mutations. Here, we report a 30-min DNA technique using Cas12a-loaded liposomes microplate reader, fundamental laboratory tool. Methods: CRISPR-Cas12a complex fluorescence-quenching (FQ) probes are introduced into tumor-derived extracellular vesicles (EV) through membrane fusion. When CRISPR-RNA hybridizes with target, activated Cas12a can trans -cleave FQ probes, resulting fluorescence signals quantification of mutation. Results: method enables EGFR L858R EV within 30 min. Laborious extraction, purification, other preparation steps eliminated. The need advanced data processing is also dispensed with. In cohort study involving 10 healthy donors non-small cell lung (NSCLC), achieved sensitivity 86.7%, specificity 90%, an accuracy 87.5%. Conclusion: limit our Cas12 ~ 8 × 105 EVs, corresponding allele frequency (MAF) 10%. MAF late-stage cancers varies widely but falls 5%-50%. Therefore, without amplification targets, this detect mutations cancer. Future advancements multiplex high-throughput will streamline self-diagnosis treatment monitoring at home.

Language: Английский

Citations

0
Pulmonary Embolism–Related Mortality in Patients With Cancer DOI Creative Commons
Marco Zuin,

Anju Nohria,

Stanislav Henkin

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2460315 - e2460315

Published: Feb. 18, 2025

Importance Acute pulmonary embolism (PE) is a major cause of morbidity and mortality in patients with cancer the US worldwide. Objectives To assess trends PE-related from 2011 to 2020 among across age, sex, ethnic racial groups, urbanicity, regionality. Design, Setting, Participants This cohort study used Centers for Disease Control Prevention Wide-Ranging Online Data Epidemiologic Research data system determine national age-adjusted rates (AAMRs) due acute PE aged 15 years or older January December 2020. Concomitant incidence that may have contributed were obtained Cancer Statistics. analyzed September November 2024. Exposure mortality. Main Outcomes Measures The primary outcome was deaths individuals cancer. AAMRs assessed using joinpoint regression modeling, expressed as an average annual percentage change (AAPC) relative 95% CIs. Results From 2020, total 27 280 194 (13 897 519 male [50.9%]; 13 382 675 female [49.1%]) died US. AAMR increased during this time period (AAPC, 2.5%; CI, 1.4% 3.6%; P = .001), without differences between sexes ( parallelism .38). those 64 3.2%; 1.9% 4.6%; non-Hispanic non-Latinx White 2.7%; 1.52% 3.94%; Black African American 2.2%; 0.7% 3.7%; Hispanic Latinx 2.6%; 4.5%; .006), residing Southern 1.3% 6.2%; .003). During same period, cancer-related decreased while absolute number new diagnoses increased. Conclusions Relevance found despite decreases rates, over last decade; concerning included rising younger years, particular region Recognition such patterns inform further research into thromboprophylaxis treatment complication cancer-directed therapy.

Language: Английский

Citations

0