Global warming and implications for epithelial barrier disruption and respiratory and dermatologic allergic diseases

Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 152(5), P. 1033 - 1046

Published: Sept. 9, 2023

Language: Английский

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Impacts of climate change on allergenic pollen production: A systematic review and meta-analysis

Agricultural and Forest Meteorology, Journal Year: 2024, Volume and Issue: 349, P. 109948 - 109948

Published: March 5, 2024

Language: Английский

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Advancements in artificial pollination of crops: from manual to autonomous

Computers and Electronics in Agriculture, Journal Year: 2025, Volume and Issue: 231, P. 110067 - 110067

Published: Feb. 5, 2025

Language: Английский

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Factors by which global warming worsens allergic disease

Annals of Allergy Asthma & Immunology, Journal Year: 2023, Volume and Issue: 131(6), P. 694 - 702

Published: Sept. 7, 2023

Language: Английский

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Climate change and epigenetic biomarkers in allergic and airway diseases

Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 152(5), P. 1060 - 1072

Published: Sept. 22, 2023

Human epigenetic variation is associated with both environmental exposures and allergic diseases can potentially serve as a biomarker connecting climate change allergy airway diseases. In this narrative review, we summarize recent human studies examining exposure to temperature, precipitation, extreme weather events, malnutrition discuss findings they relate Temperature has been the most widely studied exposure, implicating short-term long-term alterations aging. Few have examined natural disasters or events. The available reported differential DNA methylation of multiple genes pathways, some which were previously asthma allergy. integrated climate-related biomarkers, disease together. Prospective longitudinal are needed along collection target tissues beyond blood samples, such nasal skin cells. Finally, global collaboration increase diverse representation study participants, particularly those affected by injustice, well strengthen replication, validation, harmonization measurements will be elucidate impacts on epigenome. crisis one greatest threats humanity, significant allergic, immunologic, respiratory health.1Watts N. Amann M. Arnell Ayeb-Karlsson S. Belesova K. Boykoff et al.The 2019 report Lancet Countdown Health Climate Change: ensuring that health child born today not defined changing climate.Lancet. 2019; 394: 1836-1878Abstract Full Text PDF PubMed Scopus (825) Google Scholar, 2D'Amato G. Holgate S.T. Pawankar R. Ledford D.K. Cecchi L. Al-Ahmad al.Meteorological conditions, change, new emerging factors, related disorders. A statement World Allergy Organization.World Organ J. 2015; 8: 25Abstract (352) 3Katelaris C.H. Beggs P.J. change: allergens diseases.Intern Med 2018; 48: 129-134Crossref (73) 4D'Amato Chong-Neto H.J. Monge Ortega O.P. Vitale C. Ansotegui I. Rosario effects induced pollen mold allergens.Allergy. 2020; 75: 2219-2228Crossref (160) 5Sampath V. Aguilera Prunicki Nadeau K.C. Mechanisms air pollution immune system leading asthma.Semin Immunol. 2023; 67101765Crossref (2) Scholar primary driver production consumption fossil fuels—coal, crude oil, gas—which emit greenhouse gasses, carbon monoxide methane.1Watts Scholar,6Rossati A. Global warming its impact.Int J Occup Environ Med. 2017; 7-20Crossref (169) average surface temperature planet risen since preindustrial times largely because fuel use, it predicted continue increasing unless immediate efforts reduce use take place. As result, there precipitation patterns, increased frequency like wildfires hurricanes, in land patterns.6Rossati 7Hashim J.H. Hashim Z. implications Asia Pacific Region.Asia Pac Public Health. 2016; 28: 8S-14SCrossref (68) 8Ebi K.L. Vanos Baldwin J.W. Bell J.E. Hondula D.M. Errett N.A. al.Extreme population implications.Annu Rev 2021; 42: 293-315Crossref (183) burning fuels also water UV radiation exposure.9D'Amato Bergmann Annesi-Maesano Sanduzzi Liccardi al.Climate pollution.Allergo Int. 2014; 23: 17-23Crossref (33) 10Kinney P.L. quality, health.Am Prev 2008; 35: 459-467Abstract (284) 11Bais A.F. McKenzie R.L. Bernhard Aucamp Ilyas Madronich al.Ozone depletion radiation.Photochem Photobiol Sci. 14: 19-52Crossref These climatic changes our linked increases risk for wide range outcomes, including heat stroke, vector-borne illnesses, cardiopulmonary diseases, malnutrition, psychiatric conditions.12Rocque R.J. Beaudoin Ndjaboue Cameron Poirier-Bergeron Poulin-Rheault R.A. al.Health an overview systematic reviews.BMJ Open. 11e046333Crossref (306) Scholar,13Salas R.N. Solomon C.G. crisis—health care delivery.N Engl Aug 22; 381: e13Crossref (40) Relevant allergy, atmospheric conditions regions, may lead spread sources intensity duration generation.4D'Amato Scholar,14Singh A.B. Kumar P. diseases: overview.Front Allergy. 2022; 3964987Crossref Scholar,15Luschkova D. Traidl-Hoffmann Ludwig allergies.Allergo 31: 114-120Crossref (18) Therefore, more could burden epigenome lies at intersection between factors Epigenetic refer gene expression directly underlying genetic code. They allow us better characterize early biomarkers impact from their connection health.16Harb H. Renz Update epigenetics disease.J Clin 135: 15-24Abstract (80) Scholar,17Potaczek D.P. Harb Michel Alhamwe B.A. Tost Epigenetics allergy: basic mechanisms clinical applications.Epigenomics. 9: 539-571Crossref (191) marks tissue cell type specific, yield insights into responses specific organs. epidemiologic studies, once extracted (often mixed cells subject), measured after bisulfite treatment using sequencing microarrays (eg, 450K 850K/EPIC Illumina arrays [Illumina, San Diego, Calif]). commonly modification cytosine nucleotides (cytosine-phosphate-guanine dinucleotide [CpG] sites).16Harb Analytic strategies include epigenome-wide analysis, candidate approaches, testing aging, composition estimation, identification smoking) health.18Yousefi P.D. Suderman Langdon Whitehurst O. Davey Smith Relton C.L. methylation-based predictors health: applications statistical considerations.Nat Genet. 369-383Crossref (36) methodologies used highlighting potential biologic pathways development factors19Melén E. Koppelman G.H. Vicedo-Cabrera A.M. Andersen Z.J. Bunyavanich Allergies food airborne children adolescents: role environment.Lancet Child Adolesc 6: 810-819Abstract (17) 20Somineni H.K. Zhang X. Biagini Myers J.M. Kovacic M.B. Ulm Jurcak al.Ten-eleven translocation 1 (TET1) childhood traffic-related pollution.J 137: 797-805.e5Abstract (98) 21Cardenas Fadadu R.P. Van Der Laan Ward-Caviness Granger Diaz-Sanchez al.Controlled diesel exhaust: experiment bronchial epithelial cells.Environ Epigenetics. 7: dvab003Crossref (7) 22McDonald-Hyman Tager modifications Foxp3 locus exposed high levels ambient 2010; 125: AB356Abstract immunologic components aging.23Peng Cardenas Rifas-Shiman S.L. Hivert M.F. Gold D.R. Platts-Mills T.A. al.Epigenetic age acceleration Project Viva.J 143: 2263-2270.e14Abstract (39) Scholar,24Cardenas Sordillo Chung W. Liang Coull methylome inflammation children.Nat Commun. 10: 3095Crossref (109) Harnessing power field immunology provide how affect health. Although humidity, less than has,19Melén Scholar,25Ji Brandt E.B. Brokamp Ryan P.H. Khurana Hershey G.K. Air pollution, epigenetics, asthma.Allergy Asthma 12: 51Crossref (45) research plant animal models shown these ways.26Gugger P.F. Fitz-Gibbon PellEgrini Sork V.L. Species-wide patterns Quercus lobata association gradients.Mol Ecol. 25: 1665-1680Crossref (112) 27Weyrich Benz Karl Jeschek Jewgenow Fickel Paternal causes Stat3 wild guinea pig sons.Ecol Evol. 2657-2666Crossref (25) 28Weyrich Lenz Environmental change-dependent inherited response.Genes. 4Crossref 29Marsh A.G. Pasqualone A.A. stress Antarctic polychaete, Spiophanes tcherniai.Front Physiol. 5: 173Crossref (66) 30Skjærven K.H. Hamre Penglase Finn Olsvik P.A. Thermal alters involved Atlantic cod embryos.Comp Biochem Physiol Mol Integr 173C: 17-27Crossref (35) review regarding was conducted identified 15 status TLR2 NOS2).31Xu Li Guo Zhao Q. Abramson M.J. al.Environmental modifications: review.Environ Pollut. 259113840Crossref (30) However, did examine other factors. objective article first investigating change-associated exposures, We strengths, challenges, opportunities future topic. For online search original articles published topic exposures. This included mechanisms, methylation, histone modifications, non-coding RNAs, various disasters. performed 3 databases—PubMed, Web Science, EMBASE—for January 1, 2000, August 2023, combination Medical Subject Headings (MeSH) terms listed Table relevant discussed following sections organized interpretation connections outcomes. Data markers and/or annotations when available, E1 (in Online Repository www.jacionline.org). section focused recently evaluated topic, 2020.31Xu major cause direct associations excluded reviewed extensively.25Ji Scholar,32Saenen N.D. Martens D.S. Neven K.Y. Alfano Bové Janssen B.G. al.Air pollution-induced placental alterations: interplay oxidative stress, aging phenotype?.Clin 11: 124Crossref (103) Scholar,33Rider C.F. Carlsten methylation: humans.Clin 131Crossref (168) ScholarTable IDescription strategy articlesParameterDetailsDates searchJanuary 2023DatabasesPubMed, EMBASE, ScienceSearch terms"epigenetics," "epigenome," "methylome," "DNA methylation," "histone," "non-coding RNA," "temperature," "thermal," "global warming," "climate," "radiation," "humidity," "hurricane," "flooding," "heat," "wildfires," "extreme weather," temperature," "heat wave," "blizzard," "thunderstorm," "tornado," "malnutrition," "famine" Open table tab goal investigate contribute variation, prevalence, incidence, severity It important note different stages life (such utero, childhood, adulthood), differentially play affecting variability methylation.34Li Ye Mather K.A. Nguyen T.L. Dite G.S. Armstrong N.J. al.Early affects late-life through determining across lifespan: twin study.EBioMedicine. 77103927Abstract (9) particular, utero susceptible window, programming cells, organs, established during period.35Kohli R.M. Y. TET enzymes, TDG dynamics demethylation.Nature. 2013; 502: 472-479Crossref (1157) Additionally, ancestry-specific quantitative trait loci (meQTL) support inclusion ancestrally multiethnic populations studies. reflect progression, so samples key distinguishing might characterized cross-sectional (Fig 1). There several research, found literature II. step involves extraction tissues, whole blood, skin, epithelium. Once processed, analyzed variety methods, arrays.36Rauluseviciute Drabløs F. Rye data sequencing: experimental approaches recommendations tools pipelines analysis.Clin 193Crossref (52) 850K EPIC BeadChips (EWASs) systematically measure CpG sites genome large cohorts.37Campagna M.P. Xavier Lechner-Scott Maltby Scott Butzkueven al.Epigenome-wide studies: current knowledge, recommendations.Clin 13: 214Crossref Then, bioinformatic test phenotypes interest. common approach each individually all measurements, often referred methylated position. complemented entire proximity correlation structure, region (DMR) CpGs. technique assess relationship asthma, diseases.38Cardenas Epigenome-wide environment.J 152: 582-590Abstract (3) targeted selecting certain priori primers array panel inflammation) analyzing sites. An example farm milk contributed FOXP3 regulatory T (Treg) decreased atopic sensitization childhood.39Lluis Depner Gaugler B. Saas Casaca V.I. Raedler al.Increased T-cell numbers lower childhood.J 133: 551-559.e10Abstract newer methodology clocks, morbidity mortality.40Horvath Raj clock theory ageing.Nat 19: 371-384Crossref (1238) estimate predictive individual's chronologic age. Deviation measures (EAA), strong factor mortality (including due diseases) influenced example, cigarette smoking EAA among adults,41Cardenas Ecker Huen Orozco McEwen L.M. Costa Rican adults.Sci Rep. 4277Crossref (15) another showed greater higher odds having atopy allergen sensitization.23Peng IIDefinition researchTermDefinitionEWASA comprehensive genome-wide interestCpG siteDNA dinucleotides followed guanine nucleotide methyl group added methyltransferase, alter transcriptionDMRAn genomic composed samplesNon-coding RNAsFunctional molecules RNA translated proteins but protein functioningEpigenetic clocksStatistical calculators derive age, marker correlated mortalityEAADeviations calculated residuals output regressed participantmeQTLsSingle-nucleotide polymorphisms sitemeQTL, Methylation locus. meQTL, Most smoke results discordant, many EWASs frequently near promoters AHRR, FOXP3, IL4.33Rider Scholar,42Knopik V.S. Maccani M.A. Francazio McGeary maternal pregnancy development.Dev Psychopathol. 2012; 24: 1377-1390Crossref (203) Scholar,43Mukherjee Dasgupta Mishra P.K. Chaudhury changes: possible link hypersensitivity pneumonitis.Environ Sci Pollut Res 55981-56002Crossref (19) regions influence expression, AHRR methylation.44Reynolds Wan Ding Taylor J.R. Lohman Su al.DNA aryl hydrocarbon receptor repressor subclinical atherosclerosis.Circ Cardiovasc 707-716Crossref (92) Scholar,45Tsai P.C. Glastonbury C.A. Eliot M.N. Bollepalli Yet Castillo-Fernandez al.Smoking induces coordinated adipose consequences metabolic health.Clin 126Crossref (79) emerged mostly designs, limited timing directionality clear. Nonetheless, methodologic advancements show promise elucidating improve prevention treatment. Epidemiologic aggravated famine drought. tested isolated leukocytes. sections, place context microRNAs (miRNAs) outcome interest, whereas rest methylation; none them investigated modifications. Exposures chronic acute, mortality, (Table III).46Ebi Capon Berry Broderick Dear R de Havenith al.Hot extremes: risks.Lancet. 398: 698-708Abstract (311) linking fluctuations IV). responsiveness activating transient cation channels stimulating cholinergic reflex pathways.47Millqvist TRP disease—clinical significance.Temperature. 2: 172-177Crossref (16) membrane fluidity disruption transmembrane structural inflammatory response. Regarding temperature-related alterations, before 2020 summarized 7 genes31Xu Scholar; topic.Table IIISummary precipitationStudy titleAuthors (y)LocationPopulationExposureEpigenetic end pointKey finding(s)Temperature EWAS Short-Term FluctuationsBased Within-Sibship Analyses Australian FemalesWu al (2023)AustraliaAdult female twins sisters AMDTSSShort-term temperatureDNA (EWAS) peripheral leukocytes BeadChip-Temperature 14 CpGs 70 DMRs mapping 68 Associations Medium- Long-Term Exposure EAANi (2023)Augsburg, GermanyKORALa

Language: Английский

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Climate change and human health

Galenika Medical Journal, Journal Year: 2024, Volume and Issue: 3(9), P. 62 - 70

Published: Jan. 1, 2024

Compared to the end of 19th century, average temperature earth's surface is higher by 1.1o C, and last decade (2011-2020) was warmest recorded since 1850. Mortality rate high temperatures increases 1-4% for each degree increase in air due dehydration, heatstroke, worsening existing respiratory cardiovascular diseases. Natural disasters such as floods, hurricanes, storms are associated with an drowning, injuries, psychological disorders, but also contamination water food increased risk infectious Temperature changes affect interaction vectors hosts, ecosystems, existence new species a certain area, which leads diseases transmitted mosquitoes (malaria, dengue, chikungunya, West Nile virus), ticks (Lyme disease), flies (leishmaniasis), snails (schistosomiasis), etc. Animal plant diseases, addition natural pollution, further reduction amount food, results malnutrition human population, from 3.5 million people die every year. Frequent fires (increase fine particles 2.5-10 mm dust) chemical pollution concentration sulfur oxides, nitrogen ozone, smaller than 2.5 mm) cause (asthma, bronchitis, pneumonia, lung cancer) system (arteriosclerosis, myocardial infarction, deep vein thrombosis, pulmonary embolism). The change pattern vegetation, pollen air, incidence allergic will reach level pandemic 2050 about four billion suffering asthma, rhinitis atopic dermatitis. Exposure algae biotoxins marine animals, water, or causes short-term memory disorders Alzheimer's Parkinson's substances heavy metals (released destroyed warehouses sewage spills) well insecticides pesticides have immunotoxic, genotoxic carcinogenic effect. Mental that occur after range acute traumatic stress chronic conditions, post-traumatic depression, anxiety, psychosomatic sexual dysfunctions, alcohol drug abuse. long-term effects climate (natural disasters, sea rise, destruction economy, resources fuel, local wars) lead migration, migration 200 expected.

Language: Английский

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The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

Diseases, Journal Year: 2024, Volume and Issue: 12(6), P. 118 - 118

Published: June 3, 2024

According to the definition provided by United Nations, “climate change” describes persistent alterations in temperatures and weather trends. These may arise naturally, such as fluctuations solar cycle. Nonetheless, since 19th century, human activities have emerged primary agent for climate change, primarily attributed combustion of fossil fuels coal, oil, gas. Climate change can potentially influence well-being, agricultural production, housing, safety, employment opportunities all individuals. The immune system is an important interface through which global affects health. Extreme heat, events environmental pollutants could impair both innate adaptive responses, promoting inflammation genomic instability, increasing risk autoimmune chronic inflammatory diseases. Moreover, has impact on soil gut microbiome composition, further explain changes health outcomes. This narrative review aims explore disease, focusing specifically its effects microbiota. Understanding how these factors contribute development physical mental illness allow design strategies aimed at reducing negative pollution

Language: Английский

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The Influence of the Planetary Boundary Layer on the Atmospheric State at an Orographic Site at the Eastern Mediterranean

Tellus B, Journal Year: 2024, Volume and Issue: 76(1), P. 19 - 31

Published: Jan. 1, 2024

Language: Английский

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Confronting allergies: strategies for combating pollution and safeguarding our health

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 7, 2025

Increasing evidence demonstrates a robust link between environmental pollutants and allergic reactions, with air indoor pollution exacerbating respiratory allergies climate change intensifying seasonal allergies. Comprehensive action, including government regulations, public awareness, individual efforts, is essential to mitigate pollution's impact on safeguard health ecological balance. Recent findings indicate strong correlation from vehicular emissions industrial activities like asthma rhinitis. Additionally, such as mold volatile organic compounds are significant triggers of responses, especially among vulnerable populations. Furthermore, change, driven by pollution, due altered weather patterns increased pollen production. This review emphasizes the critical importance addressing allergies, highlighting growing concerns in contemporary society. highlights urgent need address emphasizing their increasing significance modern society outlining effective allergy management strategies.

Language: Английский

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Long-term changes in the allergenic potential of ruderal vegetation in a Central European urban area

Regional Environmental Change, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 15, 2025

Language: Английский

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