Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?

Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Beyond CCR7: dendritic cell migration in type 2 inflammation

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Conventional dendritic cells (cDCs) are crucial antigen-presenting that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, self-antigens. The migration of cDCs from peripheral tissues to draining lymph nodes (dLNs) is essential for their function in immune surveillance. This allows convey the conditions antigen-specific dLNs, facilitating effective responses. Migration primarily mediated by chemokine receptor CCR7, which upregulated response homeostatic inflammatory cues, guiding dLNs. However, during type 2 such as those triggered parasites or allergens, a paradox arises—cDCs exhibit robust dLNs despite low CCR7 expression. review discusses how inflammation relies on additional signaling pathways, including induced membrane-derived bioactive lipid mediators like eicosanoids, sphingolipids, oxysterols, cooperate with enhance cDC helper (Th2) differentiation. We explore potential regulatory mechanisms immunity, offering insights into differential control trafficking diverse contexts its impact

Language: Английский

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Lymphocytes Change Their Phenotype and Function in Systemic Lupus Erythematosus and Lupus Nephritis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10905 - 10905

Published: Oct. 10, 2024

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, characterized by considerable changes in peripheral lymphocyte structure and function, that plays critical role commencing reviving the inflammatory immune signaling pathways. In healthy individuals, B lymphocytes have major guiding directing defense mechanisms against pathogens. Certain phenotype, including alterations surface endosomal receptors, occur presence of SLE lead to dysregulation subpopulations. Functional are loss self-tolerance, intra- extrafollicular activation, increased cytokine autoantibody production. T seem supporting, rather than leading, disease pathogenesis. Substantial aberrations subsets evident, include reduction cytotoxic, regulatory, advanced differentiated subtypes, together with an increase activated autoreactive forms abnormalities follicular cells. Up-regulated subpopulations, such as central effector memory cells, produce pre-inflammatory cytokines, activate lymphocytes, stimulate cell This review explores pivotal roles pathogenesis Lupus Nephritis, emphasizing multifaceted interactions their phenotypic functional dysregulations.

Language: Английский

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A Mixture of Four Probiotic Strains (Probiatop®) Mitigates Food Allergy to Ovalbumin in Mice

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Language: Английский

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Development and dysfunction of structural cells in eosinophilic esophagitis

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 153(6), P. 1485 - 1499

Published: June 1, 2024

Language: Английский

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Support Enzyme Loading Influences the Effect of Aldehyde Dextran Modification on the Specificity of Immobilized Ficin for Large Proteins

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3674 - 3674

Published: Aug. 2, 2024

It has been reported that the modification of immobilized glyoxyl-ficin with aldehyde dextran can promote steric hindrances greatly reduce activity protease against hemoglobin, while still maintained a reasonable level casein. In this paper, we studied if effect may be different depending on amount ficin loaded support. For purpose, both moderately and overloaded biocatalysts were prepared modified dextran. While biocatalyst had significantly reduced activity, mainly was almost maintained. This suggests able to modify areas enzyme not available when overloaded. promoted significant increase in stability for biocatalysts, but higher (perhaps due combination inter- intramolecular crosslinking).

Language: Английский

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How type‐2 dendritic cells induce Th2 differentiation: Instruction, repression, or fostering T cell‐T cell communication?

Allergy, Journal Year: 2024, Volume and Issue: 80(2), P. 395 - 407

Published: Sept. 26, 2024

Allergic disease is caused by the activation of allergen-specific CD4+ type-2 T follicular helper cells (Tfh2) and 2 (Th2) effector that secrete cytokines IL-4, IL-5, IL-9, IL-13 upon allergen encounter, thereby inducing IgE production B tissue inflammation. While it accepted priming differentiation naïve into Th2 requires presentation type dendritic (DC2s), underlying signals remain unidentified. In this review we focus on interaction between allergen-presenting DC2s in lymph node (LN), potential mechanisms which might instruct differentiation. We outline recent advances characterizing DC2 development heterogeneity. sensing current proposed differentiation, with specific consideration role how they contribute to each mechanism. Finally, assess publications reporting a detailed analysis DC-T cell interactions LNs support Together, these studies are starting shape our understanding key initial step allergic immune response.

Language: Английский

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Changes in ficin specificity by different substrate proteins promoted by enzyme immobilization

Enzyme and Microbial Technology, Journal Year: 2024, Volume and Issue: 181, P. 110517 - 110517

Published: Sept. 21, 2024

Language: Английский

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Assessment of Hypersensitivity to House Dust Mites in Selected Skin Diseases Using the Basophil Activation Test: A Preliminary Study

Medicina, Journal Year: 2024, Volume and Issue: 60(10), P. 1608 - 1608

Published: Oct. 1, 2024

: Allergy to dust mites (HDMs) plays an important role in atopic dermatitis (AD). However, the of this allergy other dermatoses is little known. The aim study was assess hypersensitivity HDMs patients with AD or hand disease using basophil activation test.

Language: Английский

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