Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Nov. 20, 2023
Abstract
Deregulated
inflammations
induced
by
various
factors
are
one
of
the
most
common
diseases
in
people's
daily
life,
while
severe
inflammation
can
even
lead
to
death.
Thus,
efficient
treatment
has
always
been
hot
topic
research
medicine.
In
past
decades,
as
a
potential
biomaterial,
stimuli‐responsive
hydrogels
have
focus
attention
for
due
their
excellent
biocompatibility
and
design
flexibility.
Recently,
thanks
rapid
development
nanotechnology
material
science,
more
efforts
made
develop
safer,
personal
effective
therapy
some
frequent
but
tough
such
sepsis,
rheumatoid
arthritis,
osteoarthritis,
periodontitis,
ulcerative
colitis.
Herein,
from
recent
studies
articles,
conventional
emerging
delivery
anti‐inflammatory
drugs
summarized.
And
prospects
clinical
translation
future
also
discussed
further
detail.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9984 - 9984
Published: Sept. 16, 2024
Cartilage
repair
remains
a
major
challenge
in
human
orthopedic
medicine,
necessitating
the
application
of
innovative
strategies
to
overcome
existing
technical
and
clinical
limitations.
Adhesive
hydrogels
have
emerged
as
promising
candidates
for
cartilage
promotion
tissue
engineering,
offering
key
advantages
such
enhanced
integration
therapeutic
potential.
This
comprehensive
review
navigates
landscape
adhesive
repair,
discussing
identified
challenges,
shortcomings
current
treatment
options,
unique
hydrogel
products
scaffolds.
While
emphasizing
critical
need
situ
lateral
with
surrounding
tissues,
we
dissect
limitations
outline
future
perspectives
scaffolds
repair.
Moreover,
examine
translation
pathway
regulatory
considerations
specific
hydrogels.
Overall,
this
synthesizes
insights
knowledge
gaps
highlights
directions
research
regarding
hydrogel-based
devices
advancing
engineering.
Acupuncture,
rooted
in
Traditional
Chinese
Medicine
(TCM),
serves
as
a
complementary
and
alternative
therapeutic
modality
that
involves
the
insertion
of
needles
into
specific
body
points
to
stimulate
treat
variety
conditions.
Over
time,
acupuncture
has
garnered
global
acceptance,
progressively
addressing
an
increasing
spectrum
medical
disorders.
The
integration
nanotechnology
holds
considerable
potential
improve
drug
delivery
efficacy
broaden
scope
acupuncture's
applications,
providing
novel
opportunities
for
investigating
underlying
principles
meridians
acupoints.
A
bibliometric
analysis
application
over
past
two
decades
(2004-2024)
highlights
emerging
research
trends
focal
field.
This
article
provides
overview
history,
biological
mechanisms,
preparation
methods,
clinical
status
nanoacupuncture,
with
focus
on
analyzing
applications
nanoacupuncture
technology.
Nanotechnology
enables
visualization
imaging
acupoints,
facilitating
deeper
understanding
physiological
mechanisms
behind
effects.
Modified
incorporating
can
serve
dual
purposes:
functioning
sensors
real-time
monitoring
various
parameters,
thereby
supporting
disease
diagnosis
enhancing
through
specialized
interventions.
Furthermore,
nanotechnology-enhanced
act
platforms
targeted
working
tandem
responsive
nanoparticles
treatment.
Despite
its
promising
applicability,
faces
inherent
limitations
challenges
must
be
addressed.
BMC Biotechnology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: May 9, 2024
Abstract
Background
Rheumatoid
arthritis
(RA)
is
a
chronic
inflammatory
autoimmune
disease,
and
it
leads
to
irreversible
inflammation
in
intra-articular
joints.
Current
treatment
approaches
for
RA
include
non-steroidal
anti-inflammatory
drugs
(NSAIDs),
disease-modifying
anti-rheumatic
(DMARDs),
corticosteroids,
biological
agents.
To
overcome
the
drug-associated
toxicity
of
conventional
therapy
transdermal
tissue
barrier,
an
injectable
NSAID-loaded
hydrogel
system
was
developed
explored
its
efficacy.
Results
The
surface
morphology
porosity
hydrogels
indicate
that
they
mimic
natural
ECM,
which
greatly
beneficial
healing.
Further,
NSAIDs,
i.e.,
diclofenac
sodium,
were
loaded
into
hydrogel,
vitro
drug
release
pattern
found
be
burst
24
h
subsequently
sustainable
50%
up
10
days.
DPPH
assay
revealed
have
good
radical
scavenging
activity.
biocompatibility
study
carried
out
by
MTT
proved
activity
gene
expression
RAW
264.7
cells,
downregulation
several
key
genes
such
as
COX-2,
TNF-α
&
18s.
Conclusion
In
summary,
proposed
ECM-mimetic,
thermo-sensitive
situ
may
utilized
modulation
can
reducing
frequency
medication
providing
optimum
lubrication
at
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