Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(11)
Published: Oct. 29, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1110 - 1110
Published: Jan. 16, 2024
This comprehensive review elucidates the profound relationship between human microbiome and breast cancer management. Recent findings highlight significance of microbial alterations in tissue, such as gut breast, their role influencing risk, development, progression, treatment outcomes. We delve into how can modulate systemic inflammatory responses estrogen levels, thereby impacting initiation therapeutic drug efficacy. Furthermore, we explore unique diversity within indicating potential imbalances brought about by highlighting specific microbes promising targets. Emphasizing a holistic One Health approach, this underscores importance integrating insights from human, animal, environmental health to gain deeper understanding complex microbe-cancer interplay. As field advances, strategic manipulation its metabolites presents innovative prospects for enhancement diagnostics therapeutics. However, rigorous clinical trials remain essential confirm microbiota-based interventions
Language: Английский
Citations
19
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 17, 2024
Abstract Bacteria-mediated cancer therapeutic strategies have attracted increasing interest due to their intrinsic tumor tropism. However, bacteria-based drugs face several challenges including the large size of bacteria and dense extracellular matrix, limiting intratumoral delivery efficiency. In this study, we find that hyperbaric oxygen (HBO), a noninvasive method, can effectively deplete matrix thus enhance bacterial accumulation within tumors. Inspired by finding, modify Escherichia coli Nissle 1917 (EcN) with cypate molecules yield EcN-cypate for photothermal therapy, which subsequently induce immunogenic cell death (ICD). Importantly, HBO treatment significantly increases facilitates infiltration immune cells realize desirable eradication through therapy ICD-induced immunotherapy. Our work provides facile strategy efficiency natural/engineered bacteria, may promote clinical translation bacteria-mediated synergistic therapy.
Language: Английский
Citations
19
Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Language: Английский
Citations
3
Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 723 - 723
Published: Feb. 20, 2025
Background/Objectives: Tumour-associated macrophages (TAMs) are critical components of the tumour microenvironment (TME), significantly influencing cancer progression and treatment resistance. This review aims to explore innovative use engineered bacteria reprogram TAMs, enhancing their anti-tumour functions improving therapeutic outcomes. Methods: We conducted a systematic following predefined protocol. Multiple databases were searched identify relevant studies on phenotypic plasticity, for reprogramming. Inclusion exclusion criteria applied select studies, data extracted using standardised forms. Data synthesis was performed summarise findings, focusing mechanisms benefits non-pathogenic modify TAMs. Results: The summarises findings that can selectively target promoting shift from tumour-promoting M2 phenotype tumour-fighting M1 phenotype. reprogramming enhances pro-inflammatory responses activity within TME. Evidence various indicates significant regression improved immune bacterial therapy. Conclusions: Reprogramming TAMs presents promising strategy approach leverages natural targeting abilities directly tumour, potentially patient outcomes offering new insights into immune-based treatments. Further research is needed optimise these methods assess clinical applicability.
Language: Английский
Citations
1
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 170, P. 442 - 452
Published: Aug. 26, 2023
Language: Английский
Citations
14
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 22, 2024
Bacteria-based cancer therapy have demonstrated innovative strategies to combat tumors. Recent studies focused on gram-negative bacterial outer membrane vesicles (OMVs) as a novel immunotherapy strategy due its intrinsic properties versatile carrier.
Language: Английский
Citations
6
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(42), P. 10072 - 10087
Published: Jan. 1, 2023
Genetically engineered bacteria have emerged as an exciting frontier in targeted drug delivery.
Language: Английский
Citations
13
Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)
Published: May 14, 2024
Abstract Therapeutic mRNA vaccines have become powerful therapeutic tools for severe diseases, including infectious diseases and malignant neoplasms. encoding tumor‐associated antigens provide unprecedented hope many immunotherapies that hit the bottleneck. However, application of is limited because biological instability, innate immunogenicity, ineffective delivery in vivo. This study aims to construct a novel vaccine nanosystem successfully co‐deliver antigen (TAA) encoded by Wilms' tumor 1 ( WT1 ) mRNA. In this system, named PSB@Nb 1.33 C/mRNA, photosynthetic bacteria (PSB) efficiently delivers i MXene‐ core region using photo‐driven hypoxia‐driven properties. The excellent photothermal (PTT) properties PSB 2D Mxene (Nb C) trigger immunogenic cell death, which boosts release released translated, presenting TAA amplifying immune effect designed strategy demonstrates an ability inhibit distant tumors counteract postsurgical lung metastasis. Thus, provides innovative effective paradigm immunotherapy, i.e., photo‐immunogene cancer therapy, establishes efficient platform vaccines, thereby opening new path wide vaccines.
Language: Английский
Citations
5
Langmuir, Journal Year: 2024, Volume and Issue: 40(32), P. 16743 - 16756
Published: July 29, 2024
Near-infrared (NIR) phototherapies offer noninvasive, cost-effective solutions for treating tumors and microbial infections. However, organic NIR dyes commonly used suffer from solubility stability issues requiring frequent dosing. We address this challenge by exploring the bacteriophage-mediated enhancement of dye properties. Upon encapsulation within phage nanosomes, IR780 Indocyanine green (ICG), with similar optical properties but distinct water exhibit enhanced UV–vis absorbance photothermal transduction efficacy compared to liposomes. Experimental characterization corroborated all-atom molecular dynamics simulations imprints nanoscale structure, solubility, dynamics, binding these molecules membrane protein present in Phage capsid. These dye-loaded coencapsulated mitoxantrone, demonstrate anticancer activity, when combined amphotericin B, superior effects against fungal Our findings a simple efficient approach tuning performance existing through rational design therapeutic outcomes.
Language: Английский
Citations
5
Theranostics, Journal Year: 2024, Volume and Issue: 14(15), P. 5945 - 5964
Published: Jan. 1, 2024
Bacteria-mediated tumor therapy has showed promising potential for cancer therapy. However, the efficacy of bacterial monotherapy treatment which can express and release therapeutic proteins in tumors been found to be unsatisfactory. To date, synergistic emerged as a approach achieve stronger outcomes compared monotherapy. It is challenge visualize these tumor-homing bacteria
Language: Английский
Citations
5