New thiazole-based Schiff bases and their bis-analogues as potential MRSA and VRE inhibitors: One-pot synthesis, SAR, in vitro screening and in silico study

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141586 - 141586

Published: Jan. 1, 2025

Language: Английский

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Breast Cancer: Extracellular Matrix and Microbiome Interactions

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7226 - 7226

Published: June 30, 2024

Breast cancer represents the most prevalent form of and leading cause cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to appearance progression this disease. Despite advancements in breast treatment, a significant portion patients with distant metastases still experiences no cure. The extracellular matrix potential target for enhanced serum biomarkers cancer. Furthermore, degradation epithelial–mesenchymal transition constitute primary stages local invasion during tumorigenesis. Additionally, microbiome influence on diverse physiological processes. is emerging microbial dysbiosis element development various cancers, including Thus, better understanding interactions could provide novel alternatives treatment management. In review, we summarize current evidence regarding intricate relationship between microbiome. We discuss arising associations future perspectives field.

Language: Английский

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Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

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Genetically Engineered Bacteria as a Promising Therapeutic Strategy Against Cancer: A Comprehensive Review

Biotechnology and Applied Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

ABSTRACT As a significant cause of global mortality, the cancer has also economic impacts. In era therapy, mitigating side effects and costs overcoming drug resistance is crucial. Microbial species can grow inside tumor microenvironment inhibit growth through direct killing cells immunoregulatory effects. Although microbiota or their products have demonstrated anticancer effects, possibility acting as pathogens exerting in certain individuals risk. Hence, several genetically modified/engineered bacteria (GEB) been developed to this aim with ability diagnosing selective targeting destruction cancers. Additionally, GEB are expected be considerably more efficient, safer, permeable, less costly, invasive theranostic approaches compared wild types. Potential strains such Escherichia coli (Nissle 1917, MG1655), Salmonella typhimurium YB1 SL7207 ( aroA gene deletion), VNP20009 (∆msbB/∆purI) ΔppGpp (P Tet P BAD ), Listeria monocytogenes Lm at ‐LLO combat cells. When used tandem conventional treatments, substantially improve efficacy therapy outcomes. addition, public acceptance, optimal timing (s), duration dose identification, interactions other host cells, efficacy, safety quality, potential risks ethical dilemmas include major challenges.

Language: Английский

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New thiazole-based pyrazolo[1,5- a ]pyrimidine hybrids: One-pot synthesis of potential MRSA and VRE inhibitors

Synthetic Communications, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 9, 2025

Language: Английский

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Population-specific differences in the human microbiome: Factors defining the diversity

Gene, Journal Year: 2024, Volume and Issue: 933, P. 148923 - 148923

Published: Sept. 6, 2024

Language: Английский

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Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2644 - 2644

Published: Aug. 10, 2024

Breast cancer (BC) is one of the most common cancers worldwide and a leading cause cancer-related deaths among women. The escalating incidence BC underscores necessity multi-level treatment. complex heterogeneous disease involving many genetic, lifestyle, environmental factors. Growing evidence suggests that nutrition intervention an evolving effective prevention treatment strategy for BC. In addition, human microbiota, particularly gut now widely recognized as significant player contributing to health or status. It also associated with risk development This review will focus on in BC, including dietary patterns, bioactive compounds, nutrients affect therapeutic responses both animal studies. Additionally, this paper examines impacts these interventions modulating composition functionality microbiome, highlighting microbiome-mediated mechanisms combination factors microbes discussed. Insights from emphasize comprehensive management focuses nutrition–microbiome axis.

Language: Английский

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Exploring the synergistic effects of vitamin D and synbiotics on cytokines profile, and treatment response in breast cancer: a pilot randomized clinical trial

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 12, 2024

Language: Английский

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Breast Cancer-the-State-of-the Art in the World and Islamic Development Banks Members Countries (IsDB-MCs)

Published: Jan. 1, 2025

Language: Английский

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Advances in understanding therapeutic mechanisms of probiotics in cancer management, with special emphasis on breast cancer: a comprehensive review

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177410 - 177410

Published: Feb. 1, 2025

Language: Английский

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