Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 2, 2023
MOTS-c,
a
mitochondrial-derived
peptide
(MDP),
is
an
essential
regulatory
mediator
of
cell
protection
and
energy
metabolism
involved
in
the
development
specific
diseases.
Recent
studies
have
revealed
that
MOTS-c
promotes
osteoblast
proliferation,
differentiation,
mineralization.
Furthermore,
it
inhibits
osteoclast
production
mediates
regulation
bone
remodeling.
Exercise
effectively
upregulates
expression
but
mechanism
by
exercise
remains
unclear.
Therefore,
this
article
reviewed
distribution
function
tissue,
discussed
latest
research
developments
osteoblasts
osteoclasts,
proposed
potential
molecular
mechanisms
for
effect
on
metabolism.
This
review
provides
theoretical
reference
establishing
methods
to
prevent
treat
skeletal
metabolic
Animal Models and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 8, 2024
Abstract
Background
The
biomechanical
environment
created
by
suture‐button
fixation
Latarjet
is
conducive
to
the
healing
and
shaping
of
transplanted
coracoid,
but
its
mechanism
remains
unclear.
latest
research
has
found
that
absence
stem
cell
chemokine
(CXCL12)
impeded
bone
regeneration
in
Sonic
Hedgehog
(SHH)‐deficient
animals.
However,
whether
affects
SHH
CXCL12
function
not
been
studied.
Methods
Rat
fracture
models
were
constructed
simulate
stress
environments
under
non‐load‐bearing
load‐bearing
conditions.
shaping,
as
well
expression
levels
CXCL12,
assessed
through
gross
viewing,
micro‐computed
tomography
(micro‐CT),
histochemical
staining.
Results
Under
flexible
fixation,
relative
volume
(BV/TV)
rats
exposed
was
significantly
higher
than
a
(
p
≤
0.05).
Adverse
observed
subjected
fixation.
exhibited
significant
elevation
environment,
no
difference
BV/TV
between
group
rigid
≥
0.05),
there
excessive
hyperplasia
callus
group.
elevated
Conclusions
Flexible
may
contribute
influencing
suggested
this
be
relevant
coracoid
after
Latarjet.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 13, 2023
Skeletal
stem
and
progenitor
cells
(SSPCs)
are
the
multi-potent,
self-renewing
cell
lineages
that
form
hematopoietic
environment
adventitial
structures
of
skeletal
tissues.
tissues
responsible
for
a
diverse
range
physiological
functions
because
extensive
differentiation
potential
SSPCs.
The
fates
SSPCs
shaped
by
physical
properties
their
surrounding
microenvironment
mechanical
loading
forces
exerted
on
them
within
system.
In
this
context,
present
review
first
highlights
important
biomolecules
involved
with
mechanobiology
how
sense
transduce
these
signals.
then
shifts
focus
towards
static
dynamic
microenvironments
direct
biological
SSPCs,
specifically
biomaterial
tissue
engineering
systems.
Biomaterial
constructs
possess
designable,
quantifiable
enable
growth
in
controlled
environments
both
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: April 13, 2023
Bone
adapts
to
changes
in
the
physical
environment
by
modulating
remodeling
through
bone
resorption
and
formation
maintain
optimal
mass.
As
most
abundant
connexin
subtype
tissue,
43
(Cx43)-forming
hemichannels
are
highly
responsive
mechanical
stimulation
permitting
exchange
of
small
molecules
(<1.2
kDa)
between
cells
extracellular
environment.
Upon
stimulation,
Cx43
facilitate
release
prostaglandins
E
2
(PGE
),
a
vital
anabolic
factor
from
osteocytes.
Although
involved
mechanosensing,
osteocytes
principal
mechanosensitive
cells,
PGE
biosynthesis
is
greatly
enhanced
stimulation.
Mechanical
stimulation-induced
released
osteocytic
acts
as
autocrine
effects
that
promote
β
-catenin
nuclear
accumulation,
expression,
gap
junction
function,
protects
against
glucocorticoid-induced
osteoporosis
cultured
In
vivo
,
with
anabolism
response
loading.
This
review
summarizes
current
vitro
understanding
release,
their
roles
function
responses.
could
be
significant
potential
new
therapeutic
target
for
treating
loss
osteoporosis.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 2, 2023
MOTS-c,
a
mitochondrial-derived
peptide
(MDP),
is
an
essential
regulatory
mediator
of
cell
protection
and
energy
metabolism
involved
in
the
development
specific
diseases.
Recent
studies
have
revealed
that
MOTS-c
promotes
osteoblast
proliferation,
differentiation,
mineralization.
Furthermore,
it
inhibits
osteoclast
production
mediates
regulation
bone
remodeling.
Exercise
effectively
upregulates
expression
but
mechanism
by
exercise
remains
unclear.
Therefore,
this
article
reviewed
distribution
function
tissue,
discussed
latest
research
developments
osteoblasts
osteoclasts,
proposed
potential
molecular
mechanisms
for
effect
on
metabolism.
This
review
provides
theoretical
reference
establishing
methods
to
prevent
treat
skeletal
metabolic
