Roles of Myokines and Muscle-Derived Extracellular Vesicles in Musculoskeletal Deterioration under Disuse Conditions DOI Creative Commons
Jie Zhang, Yunfang Gao, Jiangwei Yan

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(2), P. 88 - 88

Published: Jan. 26, 2024

Prolonged inactivity and disuse conditions, such as those experienced during spaceflight prolonged bedrest, are frequently accompanied by detrimental effects on the motor system, including skeletal muscle atrophy bone loss, which greatly increase risk of osteoporosis fractures. Moreover, decrease in glucose lipid utilization muscles, a consequence atrophy, also contributes to development metabolic syndrome. Clarifying mechanisms involved disuse-induced musculoskeletal deterioration is important, providing therapeutic targets scientific foundation for treatment disorders under conditions. Skeletal muscle, powerful endocrine organ, participates regulation physiological biochemical functions local or distal tissues organs, itself, endocrine, autocrine, paracrine manners. As organ adjacent tissue exhibits relative lag degenerative changes compared Based this phenomenon, roles communication between bone, especially from conditions have attracted widespread attention. In review, we summarize regulatory muscle-derived myokines extracellular vesicles (EVs) occurrence loss well discuss future perspectives based existing research.

Language: Английский

The Function of Myostatin in Ameliorating Bone Metabolism Abnormalities in Individuals with Type 2 Diabetes Mellitus by Exercise DOI Creative Commons
Chenghao Zhong, Xinyu Zeng, Xiaoyan Yi

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 158 - 158

Published: Feb. 27, 2025

Purpose: The molecular mechanisms involved in bone metabolism abnormalities individuals with type 2 diabetes mellitus (T2DM) are a prominent area of investigation within the life sciences field. Myostatin (MSTN), member TGF-β superfamily, serves as critical negative regulator skeletal muscle growth and metabolism. Current research on exercise-mediated regulation MSTN expression predominantly focuses its role muscle. However, due to intricate multifaceted mechanical biochemical interactions between bone, precise by which exercise modulates enhance metabolic disorders T2DM necessitate additional exploration. objective this review is systematically synthesize evaluate development associated elucidate underlying influenced interventions, aiming offer novel insights theoretical recommendations for enhancing health through physical activity. Methods: Relevant articles Chinese English up July 2024 were selected using specific search terms databases (PubMed, CNKI, Web Science); 147 studies finally included after evaluation, reference lists checked other relevant research. Results: Myostatin’s heightened can impede various pathways, such PI3K/AKT/mTOR Wnt/β-catenin, hindering osteoblast differentiation mineralization. Additionally, it stimulate osteoclast resorption capacity facilitating Smad2-dependent NFATc1 nuclear translocation PI3K/AKT/AP-1-mediated pro-inflammatory factor thereby contributing disorders. Physical plays crucial ameliorating T2DM. Exercise activate pathways like Wnt/GSK-3β/β-catenin, suppressing myostatin downstream Smads, CCL20/CCR6, Nox4 target gene expression, fostering formation, inhibiting resorption, Conclusion: In context T2DM, has been shown exacerbate osteoblasts process mineralization while simultaneously promoting activity osteoclasts. interventions have demonstrated efficacy downregulating disrupting signaling

Language: Английский

Citations

1
The immune cells in modulating osteoclast formation and bone metabolism DOI

Jiale Hong,

Fang Luo,

Xing-Yue Du

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112151 - 112151

Published: April 28, 2024

Language: Английский

Citations

7
Non‐canonical ORFs‐derived protein products in mitochondria: A multifaceted exploration of their functions in health and disease DOI Creative Commons
Ikram Ajala, Benoît Vanderperre

Protein Science, Journal Year: 2025, Volume and Issue: 34(3)

Published: Feb. 19, 2025

Abstract Traditionally, eukaryotic mRNAs were perceived as inherently monocistronic. However, recent insights from ribosome profiling (Ribo‐seq) and proteomics studies challenge this paradigm. These investigations reveal that, beyond the currently annotated reference proteins (RefProts), there exist additional known alternative (AltProts) small open reading frames derived microproteins encoded in regions of previously considered untranslated or non‐coding transcripts. This experimental evidence broadens spectrum functional within cells, tissues, organs, potentially offering crucial into biological processes. Notably, a significant proportion these newly identified AltProts demonstrates localization mitochondria, contributing to functions mitochondrial complexes. review delves overlooked realm proteome exploring role nuclear mitochondrial‐genome‐encoded physiological pathological cellular

Language: Английский

Citations

0
Roles of Myokines and Muscle-Derived Extracellular Vesicles in Musculoskeletal Deterioration under Disuse Conditions DOI Creative Commons
Jie Zhang, Yunfang Gao, Jiangwei Yan

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(2), P. 88 - 88

Published: Jan. 26, 2024

Prolonged inactivity and disuse conditions, such as those experienced during spaceflight prolonged bedrest, are frequently accompanied by detrimental effects on the motor system, including skeletal muscle atrophy bone loss, which greatly increase risk of osteoporosis fractures. Moreover, decrease in glucose lipid utilization muscles, a consequence atrophy, also contributes to development metabolic syndrome. Clarifying mechanisms involved disuse-induced musculoskeletal deterioration is important, providing therapeutic targets scientific foundation for treatment disorders under conditions. Skeletal muscle, powerful endocrine organ, participates regulation physiological biochemical functions local or distal tissues organs, itself, endocrine, autocrine, paracrine manners. As organ adjacent tissue exhibits relative lag degenerative changes compared Based this phenomenon, roles communication between bone, especially from conditions have attracted widespread attention. In review, we summarize regulatory muscle-derived myokines extracellular vesicles (EVs) occurrence loss well discuss future perspectives based existing research.

Language: Английский

Citations

3