Clinical delivery of circular RNA: Lessons learned from RNA drug development

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114826 - 114826

Published: April 23, 2023

Language: Английский

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Recent progress in nanotechnology-based drug carriers for resveratrol delivery

Drug Delivery, Journal Year: 2023, Volume and Issue: 30(1)

Published: Feb. 28, 2023

Resveratrol is a polyphenol with diverse pharmacological activities, but its clinical efficacy limited due to low solubility/permeability, light-induced isomerization, auto-oxidation, and rapid metabolism. Nanodelivery systems, such as liposomes, polymeric nanoparticles, lipid nanocarriers, micelles, nanocrystals, inorganic nanoemulsions, protein-based exosomes, macrophages, red blood cells (RBCs) have shown great potential for improving the solubility, biocompatibility, therapeutic of resveratrol. This review comprehensively summarizes recent advances in resveratrol nanoencapsulation describes strategies improve pharmacokinetics existing nanoformulations, enhance targeting, reduce toxicity, increase drug release encapsulation efficiency. The article also suggests that order avoid safety issues, nanoformulations must be tested vivo wide range diseases.

Language: Английский

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Engineering Exosomes for Therapeutic Applications: Decoding Biogenesis, Content Modification, and Cargo Loading Strategies

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7137 - 7164

Published: July 1, 2024

Abstract: Exosomes emerge from endosomal invagination and range in size 30 to 200 nm. contain diverse proteins, lipids, nucleic acids, which can indicate the state of various physiological pathological processes. Studies have revealed remarkable clinical potential exosomes diagnosing prognosing multiple diseases, including cancer, cardiovascular disorders, neurodegenerative conditions. also be engineered deliver their cargo a specific target. However, further advancements are imperative optimize exosomes' diagnostic therapeutic capabilities for practical implementation settings. This review highlights applications, emphasizing engineering through simple incubation, biological, click chemistry techniques. Additionally, loading agents onto exosomes, utilizing passive active strategies, exploring hybrid artificial discussed. Keywords: exosome, drug delivery, diagnostics, therapeutics

Language: Английский

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Leveraging nature’s nanocarriers: Translating insights from extracellular vesicles to biomimetic synthetic vesicles for biomedical applications

Science Advances, Journal Year: 2025, Volume and Issue: 11(9)

Published: Feb. 26, 2025

Naturally occurring extracellular vesicles (EVs) and synthetic nanoparticles like liposomes have revolutionized precision diagnostics medicine. EVs excel in biocompatibility cell targeting, while offer enhanced drug loading capacity scalability. The clinical translation of is hindered by challenges including low yield heterogeneity, whereas face rapid immune clearance limited targeting efficiency. To bridge these gaps, biomimetic (SVs) emerged as innovative platforms, combining the advantageous properties liposomes. This review emphasizes critical aspects EV biology, such mechanisms EV-cell interaction source-dependent functionalities modulation, tissue regeneration, informing SV engineering. We reviewed a broad array SVs, with focus on lipid bilayered functionalized proteins. These include cell-derived nanovesicles, protein-functionalized liposomes, hybrid vesicles. By addressing current highlighting opportunities, this aims to advance SVs for transformative biomedical applications.

Language: Английский

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Advancements in Protein-Based Bionanocomposites for Targeted and Controlled Drug Delivery Systems: A Comprehensive Review

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

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Exosome-Based Carrier for RNA Delivery: Progress and Challenges

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 598 - 598

Published: Feb. 10, 2023

In the last few decades, RNA-based drugs have emerged as a promising candidate to specifically target and modulate disease-relevant genes cure genetic defects. The key applying RNA therapy in clinical trials is developing safe effective delivery systems. Exosomes been exploited vehicle for drug due their nanoscale size, high stability, biocompatibility, low immunogenicity. We reviewed summarized progress strategy application of exosome-mediated therapy. challenges exosomes carrier are also elucidated this article. molecules can be loaded into then delivered targeted cells or tissues via various biochemical physical approaches. So far, has shown potential treatment cancer, central nervous system disorders, COVID-19, other diseases. To further exploit delivery, more efforts should made overcome both technological logistic problems.

Language: Английский

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Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: April 27, 2023

Abstract A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This endows cloaked nanomaterials improved interfacial properties, superior targeting, immune evasion potential, and prolonged duration of systemic circulation. Here, we summarize recent advances in the production application exosomal membrane-coated nanomaterials. The structure, manner which exosomes communicate cells are first reviewed. is followed by a discussion types their fabrication methods. We then discuss applications biomimetic membrane-cloaked tissue engineering, regenerative medicine, imaging, treatment neurodegenerative diseases. Finally, appraise current challenges associated clinical translation membrane-surface-engineered nanovehicles evaluate future this technology.

Language: Английский

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Genetically Engineered‐Cell‐Membrane Nanovesicles for Cancer Immunotherapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 6, 2023

The advent of immunotherapy has marked a new era in cancer treatment, offering significant clinical benefits. Cell membrane as drug delivery materials played crucial role enhancing therapy because their inherent biocompatibility and negligible immunogenicity. Different cell membranes are prepared into nanovesicles (CMNs), but CMNs have limitations such inefficient targeting ability, low efficacy, unpredictable side effects. Genetic engineering deepened the critical immunotherapy, enabling genetically engineered-CMN (GCMN)-based therapeutics. To date, that surface modified by various functional proteins been developed through genetic engineering. Herein, brief overview strategies for features sources is discussed, followed description GCMN preparation methods. application GCMNs directed at different immune targets addressed challenges prospects translation.

Language: Английский

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Exosome membrane-coated nanosystems: Exploring biomedical applications in cancer diagnosis and therapy

Matter, Journal Year: 2023, Volume and Issue: 6(3), P. 761 - 799

Published: Feb. 3, 2023

Language: Английский

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Exosome-like systems: Nanotechnology to overcome challenges for targeted cancer therapies

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216151 - 216151

Published: March 29, 2023

Language: Английский

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