Electrospun Nanofibers for the Delivery of Endolysin/Dendronized Ag-NPs Complex Against Pseudomonas aeruginosa DOI Creative Commons
Magdalena Lasak, Małgorzata Łysek-Gładysińska, Karolina Lach

et al.

Nanotechnology Science and Applications, Journal Year: 2025, Volume and Issue: Volume 18, P. 57 - 70

Published: Feb. 1, 2025

As bacterial resistance to antibiotics increases, there is an urgent need identify alternative antibacterial agents and improve materials. One the controlled transport of that prevents infection with drug-resistant bacteria, especially in treatment difficult-to-heal wounds. This work presents use electrospun PLCL/PVP (poly(L-lactide-co-ε-caprolactone/polyvinylpyrrolidone) nanofibers modified two properties but different mechanisms action, is, dendritic silver nanoparticles (Dend-AgNPs) endolysin. The nanomat prepared this manner showed significant activity against antibiotic-resistant Pseudomonas aeruginosa strains, inhibiting their growth production key pigments virulence factors. Moreover, as carriers selected factors significantly reduced cytotoxicity towards human fibroblasts. results confirmed possibility using presented product innovative dressing material, opening new perspectives for wounds combating infections bacteria.

Language: Английский

Electrospun nanofibers: Exploring process parameters, polymer selection, and recent applications in pharmaceuticals and drug delivery DOI Creative Commons
Rand Abdulhussain, Adeola O. Adebisi, Barbara R. Conway

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 90, P. 105156 - 105156

Published: Nov. 10, 2023

Electrospinning is acknowledged as a versatile technique for producing polymer nanofibers. Various methods, such template synthesis, self-assembly, phase separation, and drawing, have been employed to create However, due its simplicity, adaptability, the inherently high surface area-to-volume ratio in electrospun fibers, electrospinning has emerged most suitable method nanofiber fabrication. This review delves into mechanisms of techniques establishes how overcomes challenges presented by other nanofabrication methods. The explores principles electrospinning, processing parameters, their effects on resulting fibers. It also discusses properties selection polymers used highlighting various types commonly pharmaceutical applications. Additionally, covers different configurations, discussing impact drug release profiles, along with respective advantages disadvantages. recent applications enhancing outcomes are examined, addressing crucial aspects field, improving dissolution rates, masking undesirable tastes, enabling delivery through systems. In summary, this article provides comprehensive understanding pivotal role advancing approaches.

Language: Английский

Citations

99
A Review on the Electrospinning of Polymer Nanofibers and Its Biomedical Applications DOI Open Access
Balu Alagar Venmathi Maran, Sivakamavalli Jeyachandran, Masanari Kimura

et al.

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(1), P. 32 - 32

Published: Jan. 15, 2024

Polymeric nanofibers have emerged as a captivating medium for crafting structures with biomedical applications. Spinning methods garnered substantial attention in the context of medical applications and neural tissue engineering, ultimately leading to production polymer fibers. In comparison microfibers, boasting nanometer-scale diameters offer significantly larger surface areas, facilitating enhanced functionalization. Consequently, nanofiber mats are presently undergoing rigorous evaluation myriad applications, including filters, scaffolds protective equipment, reinforcement composite materials, sensors. This review offers an exhaustive overview latest advancements processing characterization. Additionally, it engages discourse regarding research challenges, forthcoming developments production, diverse types its Electrospinning has been used convert broad range polymers into nanoparticle nanofibers, may be only approach significant potential industrial manufacturing. The basics these spinning techniques, highlighting uses well nanostructured fibers drug delivery, disease modeling, regenerative medicine, bio-sensing explored.

Language: Английский

Citations

36
A systematic review on green and natural polymeric nanofibers for biomedical applications DOI
Vishal Gavande, Saravanan Nagappan, Bongkuk Seo

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 130135 - 130135

Published: Feb. 12, 2024

Language: Английский

Citations

26
Enhancing antibacterial activity and air filtration performance in electrospun hybrid air filters of chitosan (CS)/AgNPs/PVA/cellulose acetate: Effect of CS/AgNPs ratio DOI

Romteera Chueachot,

Vinich Promarak, Sayant Saengsuwan

et al.

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 338, P. 126515 - 126515

Published: Jan. 23, 2024

Language: Английский

Citations

20
Developments of Core/Shell Chitosan-Based Nanofibers by Electrospinning Techniques: A Review DOI Creative Commons
Siriporn Taokaew, Tapanee Chuenkaek

Fibers, Journal Year: 2024, Volume and Issue: 12(3), P. 26 - 26

Published: March 12, 2024

This review is focused on the recent development of various chitosan-based nanofibers (membranes, patches, mats, and scaffolds) that have been designed into core shell structures using emulsion coaxial electrospinning techniques. Chitosan, a promising polysaccharide derived from natural sources, holds potential for diverse applications, including nanofiber production, aimed at fostering sustainability. Core/shell offer appealing features, drug encapsulation sustained release capabilities, with higher efficiency than uniaxial fibers. The fabrication core/shell nanofibers, co-spinning agents spinning parameters, such as voltage, needle size, flow rate, distance tip to collector, temperature, humidity, summarized in this work. also explores updated applications fields, textiles, medical dressings, systems, filtration membranes, food packaging. It highlights current advancements produced via innovative insights presented literature challenges associated these sustainable materials are thoroughly examined, offering valuable contributions field.

Language: Английский

Citations

19
Nanofibers enabled advanced gas sensors: A review DOI Creative Commons
Kening Lang, Tianyi Liu, Daniel J. Padilla

et al.

Advanced Sensor and Energy Materials, Journal Year: 2024, Volume and Issue: 3(2), P. 100093 - 100093

Published: Feb. 24, 2024

The advancement of gas sensor technology over the past decades has led to remarkable progress and achievements in pollution control environmental protection. Compared with other sensing materials, electrospun nanofibers have attracted significant attention, which is mainly due their unique characteristics, including but not limited high surface area, easy structure design, facile facility setup, multifunctional properties, etc., making them outstanding candidates for potential applications this field. This review provides an overview sensors, concentrating on carbon monoxide, hydrogen, dioxide, hydrogen sulfide, ammonia, nitrogen oxides, oxygen, volatile organic compounds. It begins a brief introduction materials advantages along ongoing research. principles electrospinning are then discussed. Afterward, corresponding properties diverse sensors thoroughly reviewed. Finally, future vision regarding challenges perspectives area proposed. extensive comprehensive reference utilize advanced generate novel facilitating performance high-demand areas.

Language: Английский

Citations

16
Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review DOI
Praveen Ramakrishnan,

Ramakrishnan Ramprasath,

Abdulkadhar Mohamed Jalaludeen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139663 - 139663

Published: Jan. 8, 2025

Language: Английский

Citations

4
Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review DOI Open Access
Popat Mohite, Abhijeet Puri, Shubham Munde

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 435 - 435

Published: Feb. 7, 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential

Language: Английский

Citations

3
Hybrid Materials: A Metareview DOI Creative Commons
Pedro Gómez‐Romero, Anukriti Pokhriyal, Daniel Rueda-García

et al.

Chemistry of Materials, Journal Year: 2023, Volume and Issue: 36(1), P. 8 - 27

Published: Dec. 18, 2023

The field of hybrid materials has grown so wildly in the last 30 years that writing a comprehensive review turned into an impossible mission. Yet, need for general view remains, and it would be certainly useful to draw scientific technological map connecting dots very different subfields materials, which could relate essential common characteristics these fascinating while providing overview combinations, synthetic approaches, final applications formulated this field, become whole world. That is why we decided write metareview, is, reviews provide eagle's eye complex varied landscape nevertheless share driving force: power hybridization.

Language: Английский

Citations

35
An Overview of the Electrospinning of Polymeric Nanofibers for Biomedical Applications Related to Drug Delivery DOI Creative Commons

Rabia CeCe,

Lin Jining,

Monsur Islam

et al.

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 26(1)

Published: Nov. 14, 2023

Electrospinning is a prominent technique for micro/nanofiber production and has received significant attention in the 21 st century. It enables of ultrafine fibers using variety polymers, including synthetic, natural, hybrid materials. Electrospun nanofibers (NFs) possess unique properties such as high surface‐to‐volume ratio, tunable pore structures, customizable composition, making them highly desirable various fields biomedical science, textiles, sensors, filters, energy, packaging. Herein, particular will be given to application NFs fields. The use delivery drugs, growth factors, proteins, nanoparticles, etc., holds promise field science. To combine these compounds with NFs, electrospinning techniques have been developed outstanding improvements, based on requirements type, different processes are favored. In this review, most common drug loading methods into generally used synthetic/natural polymers NF production, their systems, tissue engineering, wound dressing mentioned. Finally, challenges future perspectives above mentioned applications discussed.

Language: Английский

Citations

24