Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
incidence
of
ischemic
stroke
(IS)
is
rising
in
tandem
with
the
global
aging
population.
There
an
urgent
need
to
delve
deeper
into
pathological
mechanisms
and
develop
new
neuroprotective
strategies.
In
present
review,
we
discuss
latest
advancements
research
on
various
nanodrug
delivery
systems
(NDDSs)
for
targeting
microglial
polarization
IS
treatment.
Furthermore,
critically
different
NDDSs
have
demonstrated
exceptional
qualities
effectively
permeate
blood–brain
barrier,
aggregate
at
site
injury,
target
specific
cell
types
within
brain
when
appropriately
modified.
Consequently,
considerable
potential
reshaping
phenotype
microglia
could
be
a
prospective
therapeutic
strategy
IS.
treatment
remains
challenge.
However,
this
review
provides
perspective
neuro-nanomedicine
therapies
centered
polarization,
thereby
inspiring
ideas
directions.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11799 - 11799
Published: Nov. 2, 2024
Osteoarthritis
(OA),
a
common
and
disabling
degenerative
joint
disease,
affects
millions
of
people
worldwide
imposes
considerable
burden
on
patients
society
due
to
its
high
prevalence
economic
costs.
The
pathogenesis
OA
is
closely
related
the
progressive
degradation
articular
cartilage
accompany
inflammation;
however,
itself
cannot
heal
modulate
inflammation
lack
nerves,
blood
vessels,
lymph-vessels.
Therefore,
reliable
effective
methods
treat
remain
highly
desired.
Local
administration
drugs
or
bioactive
materials
by
intra-articular
injection
delivery
system
represents
promising
approach
OA,
especially
considering
prolonged
retention,
chondrocytes
targeting,
stimuli-responsive
release
achieve
precision
therapy.
This
article
summarizes
discusses
advances
in
currently
used
systems
(nanoparticle,
hydrogel,
liposome,
microsphere)
then
focuses
their
applications
treatment
from
perspective
endogenous
stimulus
(redox
reactions,
pH,
enzymes,
temperature)
exogenous
(near-infrared,
magnetic,
ultrasound)-responsive
release.
Finally,
challenges
potential
future
directions
for
development
nano-delivery
are
summarized.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(31), P. 40739 - 40752
Published: July 24, 2024
Oxidative
stress
(OS)
is
a
major
mediator
of
secondary
brain
injury
following
intracerebral
hemorrhage
(ICH).
Thus,
antioxidant
therapy
emerging
as
an
attractive
strategy
to
combat
ICH.
To
achieve
both
reactive
oxygen
species
(ROS)
scavenging
ability
and
on-demand
drug
release
ability,
we
constructed
novel
polydopamine
(PDA)-coated
diselenide-bridged
mesoporous
silica
nanoparticle
(DSeMSN)
delivery
system
(PDA-DSeMSN).
Edaravone
(Eda)
was
blocked
in
the
pores
DSeMSN
by
covering
with
PDA
gatekeeper.
The
maintained
nearly
"zero
release"
before
reaching
lesion
site,
while
ROS-enriched
circumstances,
shell
went
through
degradation
doped
diselenide
bonds
broke
up,
triggering
disintegration
nanoparticles
leading
Eda
release.
Interestingly,
ROS-degradable
property
bond
endowed
enhanced
ROS-eliminating
capacity.
synergistic
effect
ROS-responsive
ROS-scavenging
PDA-DSeMSN
showed
efficient
antioxidative
mitochondria
protective
performance
without
apparent
toxicity
vitro.
Importantly,
PDA-DSeMSN@Eda
intravenous
administration
specifically
accumulated
perihematomal
sites
demonstrated
robust
neuroprotection
ICH
mouse
model
antiapoptotic
effects
high
biological
safety.
platform
holds
tremendous
potential
excellent
carrier
for
drugs
provides
new
effective
clinical
treatment
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(14), P. 11274 - 11274
Published: July 10, 2023
Pestalotiopsis
sp.
is
an
important
class
of
plant
pathogenic
fungi
that
can
infect
a
variety
crops.
We
have
proved
the
pathogenicity
P.
kenyana
on
bayberry
leaves
and
caused
blight.
Phenazine-1-carboxylic
acid
(PCA)
has
characteristics
high
efficiency,
low
toxicity,
environmental
friendliness,
which
prevent
fungal
diseases
In
this
study,
effect
PCA
morphological,
physiological,
molecular
been
investigated,
potential
antifungal
mechanism
against
was
also
explored.
applied
in
vitro
vivo
to
determine
its
inhibitory
PCA.
It
found
highly
efficient
kenyana,
with
EC50
around
2.32
μg/mL,
57%
at
14
μg/mL.
The
preliminarily
explored
by
transcriptomics
technology.
results
showed
after
treatment
PCA,
3613
differential
genes
were
found,
focusing
redox
processes
various
metabolic
pathways.
addition,
it
cause
mycelial
development
malformation,
damage
cell
membranes,
reduce
mitochondrial
membrane
potential,
increase
ROS
levels.
This
result
expanded
agricultural
application
revealed
possible
kenyana.
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
incidence
of
ischemic
stroke
(IS)
is
rising
in
tandem
with
the
global
aging
population.
There
an
urgent
need
to
delve
deeper
into
pathological
mechanisms
and
develop
new
neuroprotective
strategies.
In
present
review,
we
discuss
latest
advancements
research
on
various
nanodrug
delivery
systems
(NDDSs)
for
targeting
microglial
polarization
IS
treatment.
Furthermore,
critically
different
NDDSs
have
demonstrated
exceptional
qualities
effectively
permeate
blood–brain
barrier,
aggregate
at
site
injury,
target
specific
cell
types
within
brain
when
appropriately
modified.
Consequently,
considerable
potential
reshaping
phenotype
microglia
could
be
a
prospective
therapeutic
strategy
IS.
treatment
remains
challenge.
However,
this
review
provides
perspective
neuro-nanomedicine
therapies
centered
polarization,
thereby
inspiring
ideas
directions.
