Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 539 - 539

Published: July 3, 2023

Aloe vera-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview recent advances application healing. synthesis methods, structural characteristics, properties are discussed. Mechanisms released from hydrogels, including diffusion, swelling, degradation, also analyzed. In addition, effects on healing, well reduction inflammation, antimicrobial activity, tissue regeneration, highlighted. incorporation various agents, such anti-inflammatory ones, into is reviewed detail. Furthermore, challenges future prospects dressing applications considered. This review valuable information current status highlights potential improve healing outcomes.

Language: Английский

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Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2623 - 2623

Published: Nov. 14, 2023

Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems, have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled advantages therapeutic delivery. These encompassing platforms such liposomes, protein-based nanoparticles, extracellular vesicles, and polysaccharides, are lauded for their targeted delivery, minimized side effects, enhanced outcomes. However, translation BDSs from research settings to clinical applications is fraught with challenges, including reproducibility concerns, physiological stability, rigorous efficacy safety evaluations. Furthermore, innovative nature demands reevaluation evolution existing regulatory ethical frameworks. This review provides an overview delves into multifaceted translational challenges present emerging solutions, underscored real-world case studies. Emphasizing potential redefine healthcare, we advocate sustained interdisciplinary collaboration research. As our understanding deepens, future appears promising, focus on personalized medicine refined patient-specific systems.

Language: Английский

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Trend of albumin nanoparticles in oncology: a bibliometric analysis of research progress and prospects

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 12, 2024

Background Delivery systems based on albumin nanoparticles (NPs) have recently garnered substantial interest in anti-tumor drug development. However, systematic bibliometric analyses this field remain lacking. This study aimed to analyze the current research status, hotspots, and frontiers application of NPs oncology from a perspective. Methods Using Web Science Core Collection (WOSCC) as data source, retrieved articles were analyzed using software, such VOSviewer 1.6.18 CiteSpace 6.1.6, relevant visualization maps plotted. Results From 1 January 2000, 15 April 2024, 2,262 institutions 67 countries/regions published 1,624 related oncology. The USA was leader held formidable academic reputation. most productive institution Chinese Academy Sciences. author Youn YS, whereas Kratz F frequently co-cited author. journal International Journal Nanomedicine , Controlled Release journal. Future hotspots included “rapid convenient synthesis methods predominated by self-assembly,” “surface modification,” “construction multifunctional for theranostics,” “research natural active ingredients mainly phenolic compounds,” “combination therapy,” “clinical applications.” Conclusion Based our analysis summary, we obtained an overview oncology, identified influential countries, institutions, authors, journals, citations, discussed field. Our may serve important reference future

Language: Английский

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Serum Albumin in Nasal Drug Delivery Systems: Exploring the Role and Application

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1322 - 1322

Published: Oct. 11, 2024

The application of serum albumin in various types formulations has emerged as a valuable option biomedical research, especially the field nasal drug delivery systems. A albumin-based carrier system been employed due to several benefits, such enhancing solubility and stability, generating desired controlled release profile, developing favorable properties with respect challenges conditions, which, this case, involves hindering rapid elimination mucociliary clearance. Accordingly, considering important role albumin, in-depth knowledge related its utilization preparing formulation is highly encouraged. This review aimed explore potential fabricating crucial functionality regarding binding interaction mucin, which significantly determines successful administration formulations.

Language: Английский

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Apoptosis and cell cycle arrest of bone marrow cells by green-synthesized silver but not albumin nanoparticles

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101960 - 101960

Published: Feb. 13, 2025

Language: Английский

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Development of novel plant protein with low gelation concentration from Torreya grandis nuts: Effect and mechanism of metal cations on its thermal gelation behavior

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 143909 - 143909

Published: March 1, 2025

Language: Английский

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Crafting Docetaxel-Loaded Albumin Nanoparticles Through a Novel Thermal-Driven Self-Assembly/Microfluidic Combination Technology: Formulation, Process Optimization, Stability, and Bioavailability

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5071 - 5094

Published: May 31, 2024

The commercial docetaxel (DTX) formulation causes severe side effects due to polysorbate 80 and ethanol. Novel surfactant-free nanoparticle (NP) systems are needed improve bioavailability reduce effects. However, controlling the particle size stability of NPs improving batch-to-batch variation major challenges.

Language: Английский

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Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

Published: Sept. 28, 2023

Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems, have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled advantages therapeutic delivery. These encompassing platforms such liposomes, protein-based nanoparticles, extracellular vesicles, and polysaccharides, are lauded for their targeted delivery, minimized side effects, enhanced outcomes. However, translation BDSs from research settings to clinical applications is fraught with challenges, including reproducibility concerns, physiological stability, rigorous efficacy safety evaluations. Furthermore, innovative nature demands reevaluation evolution existing regulatory ethical frameworks. This review provides an overview BDSs, delve into multifaceted translational challenges present emerging solutions, underscored real-world case studies. Emphasizing potential redefine healthcare, we advocate sustained interdisciplinary collaboration research. As our understanding deepens, future appears promising, focus on personalized medicine refined patient-specific systems.

Language: Английский

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Enhanced efficacy of quercetin and taxifolin encapsulated with pH-responsive injectable BSA hydrogel for targeting triple-negative breast cancer cells

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138477 - 138477

Published: Dec. 11, 2024

Language: Английский

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Synthesis, characterizations, and anticancer properties of bifunctional system based on gold(I) alkynyl and antipyrine

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1016, P. 123241 - 123241

Published: June 18, 2024

Language: Английский

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