Electrosprayed Core (Cellulose Acetate)–Shell (Polyvinylpyrrolidone) Nanoparticles for Smart Acetaminophen Delivery DOI Creative Commons
Lin Xu, Hua He, Yutong Du

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2314 - 2314

Published: Sept. 13, 2023

Smart drug delivery, through which the molecules are delivered according to requests of human biological rhythms or by maximizing therapeutic effects, is highly desired in pharmaceutics. Many biomacromolecules have been exploited for this application past few decades, both industry and laboratories. Biphasic release, with an intentional pulsatile release a following extended stage, represents typical smart delivery approach, aims provide fast action long time period effective blood concentration patients. In study, based on use well-known biomacromolecule, i.e., cellulose acetate (CA), as (acetaminophen, ATP)-based sustained carrier, modified coaxial electrospraying process was developed fabricate new kind core–shell nanoparticle. The nanoparticles were able furnish ATP due shell polyvinylpyrrolidone (PVP). cost 30% 0.32 h, whereas particles 30.84-h 90% loaded ATP. scanning electron microscope transmission results verified terms their round surface morphologies obvious double-chamber structures. presented core sections amorphous state owing its fine compatibility CA PVP. controlled mechanisms suggested. disclosed biomacromolecule-based process–structure–performance relationship can shed light how develop sorts advanced nano systems.

Language: Английский

Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance DOI
Jianfeng Zhou, Tao Yi, Zhiyuan Zhang

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2023, Volume and Issue: 6(6)

Published: Oct. 17, 2023

Language: Английский

Citations

80
Electrosprayed Stearic-Acid-Coated Ethylcellulose Microparticles for an Improved Sustained Release of Anticancer Drug DOI Creative Commons

Yuexin Ji,

Hua Zhao,

Hui Liu

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(9), P. 700 - 700

Published: Aug. 29, 2023

Sustained release is highly desired for "efficacious, safe and convenient" drug delivery, particularly those anticancer molecules with toxicity. In this study, a modified coaxial electrospraying process was developed to coat hydrophobic lipid, i.e., stearic acid (SA), on composites composed of the tamoxifen citrate (TC) insoluble polymeric matrix ethylcellulose (EC). Compared electrosprayed TC-EC composite microparticles M1, SA-coated hybrid M2 were able provide an improved TC sustained-release profile. The 30% 90% loaded time periods extended 3.21 h 19.43 M2, respectively, which significantly longer than provided by M1 (0.88 9.98 h, respectively). morphology, inner structure, physical state, compatibility components particles disclosed through SEM, TEM, XRD, FTIR. Based analyses, mechanism multiple factors co-acting suggested, include reasonable selections organizations lipid excipient, blank SA shell loading, regularly round shape, also high density. reported protocols pioneered brand-new manner developing sustained delivery hybrids combination cellulose gels using electrospraying.

Language: Английский

Citations

67
Engineered shapes using electrohydrodynamic atomization for an improved drug delivery DOI
Deng‐Guang Yu,

Wenjian Gong,

Jianfeng Zhou

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning electrospraying, are facile in manipulate products' shapes. In this review, generated using EHDA for modifying drug release profiles reviewed. These linear nanofibers, round micro‐/nano‐particles, beads‐on‐a‐string hybrids. They can be further divided into different kinds sub‐shapes, explored providing desired pulsatile release, sustained biphasic delayed pH‐sensitive release. Additionally, resulted from organizations electrospun nanofibers discussed delivery, inner structures considered together developing novel delivery systems. future, related shape–performance relationships at nanoscale, besides size, structure structure–performance relationships, would play important roles promoting developments field. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies

Language: Английский

Citations

64
Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites DOI Creative Commons
Chen Shu, Jianfeng Zhou,

Boya Fang

et al.

Macromolecular Materials and Engineering, Journal Year: 2023, Volume and Issue: 309(4)

Published: Nov. 23, 2023

Abstract In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by novel spinneret, is homemade conducting processes. The types electrospun nanofibers E1, electrosprayed microparticles E2, core‐shell E3. SEM TEM results indicate that they have anticipated morphologies inner structures. X‐ray diffraction Fourier Transform Infrared verify KET mainly amorphous in all composites due its fine compatibility with HPMC. vitro tests demonstrate rapid release performances has an order E3>E1>E2≫KET powders. mechanisms suggested advantages compared. super performance E3 furnishing attributed synergistic action small size (of shell thickness), high porosity, state drug, solubility nanostructures can support development nano delivery systems (DDSs) through tailoring spatial distribution molecules within products.

Language: Английский

Citations

62
Tri-Layer Core–Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole DOI Creative Commons
Ying Wang, Lin Liu,

Yuanjie Zhu

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2561 - 2561

Published: Oct. 31, 2023

Polymers are the backbone of drug delivery. Electrospinning has greatly enriched strategies that have been explored for developing novel delivery systems using polymers during past two decades. In this study, four different kinds polymers, i.e., water-soluble polymer poly (vinyl alcohol) (PVA), insoluble poly(ε-caprolactone) (PCL), Eudragit RL100 (ERL100) and pH-sensitive S100 (ES100) were successfully converted into types tri-layer tri-polymer core-shell fibers through bi-fluid coaxial electrospinning. During process, model metronidazole (MTD) was loaded shell working fluid, which an emulsion. The micro-formation mechanism from emulsion electrospinning proposed. Scanning electron microscope transmission evaluations verified linear morphology resultant their obvious multiple-chamber structures. X-ray diffraction Fourier transform infrared spectroscopy measurements demonstrated MTD presented in amorphous state compatible with three polymeric matrices. vitro dissolution tests could act a synergistic manner prolonged sustained-release profile gut. controlled-release mechanisms suggested detail. protocols reported here pioneer new route creating structure both aqueous organic solvents, strategy advanced sophisticated profiles.

Language: Английский

Citations

56
A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines DOI Creative Commons
Liang Sun, Jianfeng Zhou, Yaoning Chen

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Nov. 15, 2023

Bacterial prostatitis is a challenging condition to treat with traditional dosage forms. Physicians often prescribe variety of forms different administration methods, which fail provide an efficient and convenient mode drug delivery. The aim this work was develop new type hybrid material incorporating both electrosprayed core-shell microparticles electrospun nanofibers. A Chinese medicine (Ningmitai, NMT) Western (ciprofloxacin, CIP) were co-encapsulated within designed be released in separately controlled manner. Utilizing polyvinylpyrrolidone (PVP) as hydrophilic filament-forming polymer pH-sensitive Eudragit ® S100 (ES100) the particulate polymeric matrix, combined electrohydrodynamic atomization (EHDA) method comprising coaxial electrospraying blending electrospinning, used create hybrids single-step straightforward series characterization methods conducted analyze working process its final products. Scanning electron microscopy transmission revealed that EHDA comprised CIP-PVP nanofibers NMT-ES100 microparticles. Multiple confirmed rapid release CIP sustained NMT. antibacterial experiments indicated exhibited more potent effect against Escherichia coli dh5α Bacillus subtilis Wb800 than either separate or amalgamation fibrous nanomedicine micromedicine can expand horizon types medicines. integration electrospinning provides approach fabrication. By combining soluble polymers hybrids, we ensure sequential NMT for potential synergistic therapy bacterial prostatitis.

Language: Английский

Citations

51
Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review DOI Creative Commons
Zhiyuan Zhang, Hui Liu, Deng‐Guang Yu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 789 - 789

Published: July 3, 2024

Alginate is a natural polymer with good biocompatible properties and potential polymeric material for the sustainable development replacement of petroleum derivatives. However, non-spinnability pure alginate solutions has hindered expansion applications. With continuous electrospinning technology, synthetic polymers, such as PEO PVA, are used co-spinning agents to increase spinnability alginate. Moreover, coaxial, parallel Janus, tertiary other diverse novel electrospun fiber structures prepared by multi-fluid have found new breakthrough problem poor spinning polymers. Meanwhile, effectively achieve multiple release modes drugs. The powerful combination electrostatic widely in many biomedical fields, tissue engineering, regenerative bioscaffolds, drug delivery, research fever continues climb. This particularly true controlled delivery aspect review provides brief overview alginate, introduces advances spinning, highlights progress alginate-based nanofibers achieving various modes, pulsed release, sustained biphasic responsive targeted release.

Language: Английский

Citations

50
Engineered beads-on-a-string nanocomposites for an improved drug fast-sustained bi-stage release DOI Creative Commons

Wenjian Gong,

Wei Yang, Jianfeng Zhou

et al.

Nanocomposites, Journal Year: 2024, Volume and Issue: 10(1), P. 240 - 253

Published: June 12, 2024

Language: Английский

Citations

39
Integrated Janus nanofibers enabled by a co-shell solvent for enhancing icariin delivery efficiency DOI
Yuhao Sun, Jianfeng Zhou, Zhiyuan Zhang

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124180 - 124180

Published: May 4, 2024

Language: Английский

Citations

38
Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications DOI Creative Commons

Xuewen Jiang,

Yue Zeng, Chaofei Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 5, 2024

Diabetic wounds are a significant subset of chronic characterized by elevated levels inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They also associated with impaired angiogenesis, persistent infection, high likelihood hospitalization, leading to substantial economic burden for patients. In severe cases, amputation or even mortality may occur. foot ulcers (DFUs) common complication diabetes, up 25% diabetic patients being at risk developing over their lifetime, more than 70% ultimately requiring amputation. Electrospun scaffolds exhibit structural similarity the extracellular (ECM), promoting adhesion, growth, migration fibroblasts, thereby facilitating formation new skin tissue wound site. The composition size electrospun can be easily adjusted, enabling controlled drug release through fiber structure modifications. porous nature these facilitates gas exchange absorption exudate. Furthermore, surface readily modified impart specific functionalities, making electrospinning nanofiber highly promising treatment wounds. This article provides concise overview healing process in normal pathological mechanisms underlying wounds, including complications such as ulcers. It explores advantages treatment. Additionally, it summarizes findings from various studies on use different types reviews methods loading onto scaffolds. These advancements broaden horizon effectively treating

Language: Английский

Citations

36