Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 8 - 8

Published: Jan. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Language: Английский

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Nanocarriers for targeted drug delivery in the vascular system: focus on endothelium

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 12, 2024

Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics, and modulating inflammatory responses. Nanocarriers hold transformative potential for precise drug delivery within the system, particularly targeting ECs therapeutic purposes. However, complex interactions between nanocarriers present significant challenges development clinical translation of nanotherapeutics. This review assesses recent advancements key strategies employing to ECs. It suggested that through physicochemical design surface modifications, can enhance specificity improve internalization efficiency Additionally, we elaborated on applications specifically designed treatment cardiovascular diseases, cancer metastasis, disorders. Despite these advancements, safety concerns, complexity vivo processes, challenge achieving subcellular remain obstacles effective with nanocarriers. A comprehensive understanding endothelial cell biology its interaction is crucial realizing full targeted systems.

Language: Английский

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Advances in tumor vascular growth inhibition

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: 26(9), P. 2084 - 2096

Published: March 20, 2024

Language: Английский

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Elevated accumulation of lutein and zeaxanthin in a novel high-biomass yielding strain Dunaliella sp. ZP-1 obtained through EMS mutagenesis

Biotechnology for Biofuels and Bioproducts, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 27, 2025

Abstract Background Dunaliella microalgae, such as salina riching in β-carotene and bardawil rich lutein α-carotene, have been used aquaculture, supplements, cosmetics, feed industries. The genus is diverse; therefore, characterization of novel strains isolation new varieties through mutagenesis technology will promote natural carotenoid bioproduction. Results Salt stress test demonstrated that the newly isolated microalgae strain ZP-1 was a halotolerant strain. Morphology observation molecular phylogeny analysis indicated unicellular green microalga member . Biomass RAM medium up to 2.45 g/L, showing advantage over other common terms yield. Furthermore, Ethyl methanesulfonate (EMS) mutant library generated from this high-biomass strain, aiming improve productivity. A selected morphology combining with quantification by HPLC, which nominated turn yellow dunaliella 4 ( tyd4 ). displayed an increased productivity 28.55% zeaxanthin 22.19%. promoted 17.40% continuous culture under red light. Application exogenous 1.0 μM melatonin on led cell density improved biomass. Conclusions study support EMS effective breeding approach for further improvement sp. ZP-1, exhibiting potential overcome bottleneck low biomass current commercial strains. had higher contents both zeaxanthin, whose yield could be elevated light melatonin. This provided sources scientific research technical reference bioproduction carotenoids.

Language: Английский

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Protein-based nano delivery systems focusing on protein materials, fabrication strategies and applications in ischemic stroke intervention: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143645 - 143645

Published: April 29, 2025

Language: Английский

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Advancing Yarrowia lipolytica sub-organelle engineering with endogenous mitochondrial targeting sequence

Biotechnology Letters, Journal Year: 2025, Volume and Issue: 47(3)

Published: May 8, 2025

Language: Английский

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Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1848 - 1848

Published: April 18, 2024

In recent years, the frequency of strokes has been on rise year by and become second leading cause death around world, which is characterized a high mortality rate, recurrence disability rate. Ischemic account for large percentage strokes. A reperfusion injury in ischemic complex cascade oxidative stress, neuroinflammation, immune infiltration, mitochondrial damage. Conventional treatments are ineffective, presence blood–brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers turning their attention nano-drug systems. Functionalized systems have widely studied applied study cerebral diseases due favorable biocompatibility, efficiency, strong specificity, specific targeting ability. this paper, we briefly describe pathological process injuries focus therapeutic research progress strokes, aiming provide certain references understand (NDDSs).

Language: Английский

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Advances in nephroprotection: the therapeutic role of selenium, silver, and gold nanoparticles in renal health

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

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Establishment of a Biaxial Testing System for Characterization of Right Ventricle Viscoelasticity Under Physiological Loadings

Cardiovascular Engineering and Technology, Journal Year: 2024, Volume and Issue: 15(4), P. 405 - 417

Published: March 11, 2024

Language: Английский

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Optical lateral flow assays in early diagnosis of SARS-CoV-2 infection

Analytical Sciences, Journal Year: 2024, Volume and Issue: 40(9), P. 1571 - 1591

Published: May 17, 2024

So far, the 2019 novel coronavirus (COVID-19) is spreading widely worldwide. The early diagnosis of infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) essential to provide timely treatment and prevent its further spread. Lateral flow assays (LFAs) have advantages rapid detection, simple operation, low cost, ease mass production, no need for special devices professional operators, which make them suitable self-testing at home. This review focuses on SARS-CoV-2 based optical LFAs including colorimetric, fluorescent (FL), chemiluminescent (CL), surface-enhanced Raman scattering (SERS) detection antigens nucleic acids. types recognition components, modes used antigen labels employed in different LFAs, strategies improve sensitivity were reviewed. Meanwhile, coupled with acid amplification techniques CRISPR–Cas systems acids summarized. We hope this provides research mentalities developing highly sensitive that can be home infection.

Language: Английский

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