Effect of the Addition of Inorganic Fillers on the Properties of Degradable Polymeric Blends for Bone Tissue Engineering DOI Creative Commons
Stanisław Marecik, Iwona Pudełko, Mareeswari Balasubramanian

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3826 - 3826

Published: Aug. 12, 2024

Bone tissue exhibits self-healing properties; however, not all defects can be repaired without surgical intervention. engineering offers artificial scaffolds, which act as a temporary matrix for bone regeneration. The aim of this study was to manufacture scaffolds made poly(lactic acid), poly(ε-caprolactone), poly(propylene fumarate), and poly(ethylene glycol) modified with bioglass, beta tricalcium phosphate (TCP), and/or wollastonite (W) particles. were fabricated using gel-casting method observed optical scanning electron microscopes. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR), differential calorimetry (DSC), thermogravimetry (TG), wettability, degradation tests conducted. highest content TCP W in the composition caused hydrophilicity (water contact angle 61.9 ± 6.3°), fastest rate (7% mass loss within 28 days), moderate ability precipitate CaP after incubation PBS, no cytotoxicity L929 cells. hydrophobicity 83.4 1.7°), lowest thermal stability, slower (3% did evoke precipitation. Moreover, some signs on day 1 observed. samples both showed properties best cytocompatibility 4. Interestingly, they covered typical cauliflower-like hydroxyapatite deposits phosphate-buffered saline (PBS), might sign their excellent bioactivity.

Language: Английский

Research Progress in 3D Printed Biobased and Biodegradable Polyester/Ceramic Composite Materials: Applications and Challenges in Bone Tissue Engineering DOI

Shunshun Zhu,

Hongnan Sun, Taihua Mu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(2), P. 2791 - 2813

Published: Jan. 6, 2025

Transplantation of bone implants is currently recognized as one the most effective means treating defects. Biobased and biodegradable polyester composites combine good mechanical degradable properties polyester, thereby providing an alternative for implant materials. Bone tissue engineering (BTE) accelerates defect repair by simulating microenvironment. Composite scaffolds support formation further accelerate process repair. The introduction 3D printing technology enables preparation to be more precise, reproducible, flexible, which a very promising development. This review presents physical BTE summarizes strategies adopted domestic international scholars improve based on biobased polyester/ceramic in recent years. In addition, future development prospects field challenges expanding production clinical applications are presented.

Language: Английский

Citations

1
Evaluating the Mechanical and Tribological Properties of 3D Printed PLA/n‐HA/PA66 Composite DOI Open Access
Yonggang Guo, Zichao Guo,

Zhendong Yin

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

ABSTRACT Artificial implants are necessary for orthopedic treatment and the recovery of bone joint function in disabled individuals. However, existing materials present challenges manufacturing complex structures limited terms mechanical frictional properties. Current research is focused on development new environmentally friendly polymer composites manufacture artificial implants, combined with 3D printing technology to improve design flexibility. In this study, nine kinds PLA/n‐HA/PA66 composite scaffolds different proportions were prepared using light‐curing technology. The physical, mechanical, tribological properties compared. results showed that scaffold was superior traditional polymers, compressive strength increased by 30–40 MPa wear resistance 27%–64%. This indicates it has wide application potential tissue engineering.

Language: Английский

Citations

0
Mechanical and biological properties of 3D printed bone tissue engineering scaffolds DOI Creative Commons

M R Wang,

Yunpeng Xu, Ling Cao

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 4, 2025

Bone defects have historically represented a significant challenge in clinical practice, with traditional surgical intervention remaining the gold standard for their management. However, due to problem of origin autologous and allogeneic bone complex diverse defects, methods sometimes cannot meet treatment needs expectations patients. The development tissue engineering 3D printing technology provides new ideas defect repair. Ideal bioscaffold materials must good mechanical properties, biocompatibility, osteoinduction conduction capabilities. Additionally, factors such as degradation rate, appropriate porosity sustained antibacterial effect be taken into account. combination synthetic composite biomaterial scaffolds has become well-established approach offering innovative solutions combined application seed cells, signalling biological is also beneficial improve therapeutic defects. This article will therefore examine some most commonly used technologies prevalent suitable printing. An analysis conducted on properties these elucidate respective advantages limitations.

Language: Английский

Citations

0
UV-cured 3D printing interbody fusion cage based on polymer composite DOI

Mingfeng Gao,

Jiafeng Yao, Yan Wang

et al.

Journal of materials research/Pratt's guide to venture capital sources, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Effect of the Addition of Inorganic Fillers on the Properties of Degradable Polymeric Blends for Bone Tissue Engineering DOI Creative Commons
Stanisław Marecik, Iwona Pudełko, Mareeswari Balasubramanian

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3826 - 3826

Published: Aug. 12, 2024

Bone tissue exhibits self-healing properties; however, not all defects can be repaired without surgical intervention. engineering offers artificial scaffolds, which act as a temporary matrix for bone regeneration. The aim of this study was to manufacture scaffolds made poly(lactic acid), poly(ε-caprolactone), poly(propylene fumarate), and poly(ethylene glycol) modified with bioglass, beta tricalcium phosphate (TCP), and/or wollastonite (W) particles. were fabricated using gel-casting method observed optical scanning electron microscopes. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR), differential calorimetry (DSC), thermogravimetry (TG), wettability, degradation tests conducted. highest content TCP W in the composition caused hydrophilicity (water contact angle 61.9 ± 6.3°), fastest rate (7% mass loss within 28 days), moderate ability precipitate CaP after incubation PBS, no cytotoxicity L929 cells. hydrophobicity 83.4 1.7°), lowest thermal stability, slower (3% did evoke precipitation. Moreover, some signs on day 1 observed. samples both showed properties best cytocompatibility 4. Interestingly, they covered typical cauliflower-like hydroxyapatite deposits phosphate-buffered saline (PBS), might sign their excellent bioactivity.

Language: Английский

Citations

2