Biomaterial Scaffolds for Periodontal Tissue Engineering

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 233 - 233

Published: Aug. 20, 2024

Advanced periodontitis poses a significant threat to oral health, causing extensive damage and loss of both hard soft periodontal tissues. While traditional therapies such as scaling root planing can effectively halt the disease’s progression, they often fail fully restore original architecture function tissues due limited capacity for spontaneous regeneration. To address this challenge, tissue engineering has emerged promising approach. This technology centers on utilization biomaterial scaffolds, which three-dimensional (3D) templates or frameworks, supporting guiding regeneration tissues, including ligament, cementum, alveolar bone, gingival tissue. These scaffolds mimic extracellular matrix (ECM) native aiming foster cell attachment, proliferation, differentiation, and, ultimately, formation new, functional structures. Despite inherent challenges associated with preclinical testing, intensification research coupled continuous advancement fabrication technology, leads us anticipate expansion in their application review comprehensively covers recent advancements engineered specifically regeneration, provide insights into current state field potential directions future research.

Language: Английский

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Approaches to Establish an Animal Model With Composite Bone-soft Tissue Defects for Complex Regenerative Strategies

Journal of Craniofacial Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Regenerative strategies of composite tissue defects represent a formidable clinical challenge due to the distinct regeneration pathways each type and their complex interactions. To address limitations single-tissue defect models, authors firstly established an animal model with simultaneously bone-soft then observed wound healing, body weight, overall health after operation. The soft exhibited complete macroscopic closure within 21 days. Furthermore, micro-computed tomography histological assessments at 8 weeks demonstrated that calvarial was unhealed, confirming its characteristics as critical-size defect. In authors' model, 5 mm remained unhealed weeks, suggesting it also exhibits properties, though direct comparison classical requires further validation. Quantitative evaluations revealed limited new bone formation confined primarily margins, while central portion filled fibrous tissue. This not only advances understanding multitissue repair processes but offers valuable preclinical platform for development optimization next-generation regenerative injuries.

Language: Английский

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Antibacterial Ceramics for Dental Applications

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4553 - 4553

Published: April 21, 2025

Background: The aim of this review was to evaluate the antibacterial properties functionalized bioceramics for dental applications. Methods: electronic databases PubMed, Medline, ProQuest, and Google Scholar were used search peer-reviewed scientific publications published between 2020 2025 that provide insights answer research questions related role antibacterial-functionalized in combating pathogens dentistry without triggering immune reactions inflammation, as well on their efficacy against various whether understanding mechanism can promote development glass-ceramic bioceramic with long-term activity. keywords were: bioglass, bioceramic, biocompatible, antibacterial, osseointegration, implant, bioactive materials. Results: Bacterial infections play a key longevity medical devices. A crucial problem is drug-resistant bacteria. Antibacterial ceramics have received great attention recently because activity, good mechanical properties, biocompatibility, bioactivity. This provides detailed examination complex interactions bacteria, cells, from clinical perspective. focus researchers developing new-generation multifunctionality, particular are independent conventional antibiotics. highlight exploration dual functions such promoting bone regeneration which potential revolutionize implant technology. Another modifying surface hydrophilic hydrophobic order increase activity bioceramics. Conclusions: help understand current state-of-the-art activities bioceramics, could application.

Language: Английский

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Local Drug Delivery Systems as Novel Approach for Controlling NETosis in Periodontitis

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1175 - 1175

Published: Sept. 6, 2024

Periodontitis is a chronic inflammation caused by periodontopathogenic bacteria in the dental biofilm, and also involves inflammatory-immune response of host. Polymorphonuclear neutrophils (PMNs) play essential roles bacterial clearance multiple mechanisms, including formation neutrophil extracellular traps (NETs) that retain destroy pathogens. During PD progression, interaction between PMNs, NETs, leads to an exaggerated immune prolonged inflammatory state. As lesion matures, PMNs accumulate periodontal tissues die via NETosis, ultimately resulting tissue injury. A better understanding role associated molecules, pathogenic pathways NET periodontitis, could provide markers NETosis as reliable diagnostic prognostic tools. Moreover, assessment biomarker levels biofluids, particularly saliva or gingival crevicular fluid, be useful for monitoring periodontitis progression treatment efficacy. Preventing excessive accumulation tissues, both controlling NETs' their appropriate removal, key further development more efficient therapeutic approaches. In therapy, local drug delivery (LDD) systems are targeted, enhancing bioavailability active pharmacological agents pocket surrounding time ensure optimal outcome.

Language: Английский

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Aluminum-Free Borosilicate Glass Functionalized Hydrogels for Enhanced Dental Tissue Regeneration

Materials, Journal Year: 2024, Volume and Issue: 17(23), P. 5862 - 5862

Published: Nov. 29, 2024

Hydrogels are promising scaffolds for tissue regeneration, and borosilicate glass particles have demonstrated potential in enhancing the biological behaviour of dental pulp cells. However, specific morphological characteristics lesions diverse requirements tissues require biocompatible, bioactive, shapeable scaffolds. This study aimed to evaluate vitro human gingival fibroblasts (HGFs) contact with an experimental aluminum-free glass-functionalized hydrogel. Two types were utilized, Biodentine® serving as a reference material. The hydrogel, based on poly(L-lysine) dendrimers (DGL) or without particles, was analyzed using micro-computed tomography (µCT) scanning electron microscopy (SEM) coupled energy-dispersive X-ray spectroscopy (EDX). Cytocompatibility assessed Live/Dead™ staining, cell colonization evaluated via confocal imaging. Additionally, Alizarin red staining performed assess mineralization after 7 14 days. Results indicated that incorporation did not alter hydrogel porosity, while EDX confirmed particle presence surfaces. Furthermore, borosilicate-functionalized hydrogels significantly enhanced proliferation, colonization, content calcium deposits. These findings highlight these future clinical applications pending further development.

Language: Английский

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