Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review DOI Creative Commons

Rashmi Hulimane Shivaswamy,

Pranav Binulal,

Aloysious Benoy

et al.

ACS Materials Au, Journal Year: 2024, Volume and Issue: 5(1), P. 115 - 140

Published: Nov. 28, 2024

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.

Language: Английский

Hydrogel-Forming Microneedles in the Management of Dermal Disorders Through a Non-Invasive Process: A Review DOI Creative Commons
Popat Mohite, Abhijeet Puri, Shubham Munde

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 719 - 719

Published: Nov. 7, 2024

Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (HFMNs) represent transformative advancement management of diseases through non-invasive drug delivery. These innovative devices consist micrometer-sized needles made native or crosslinked hydrophilic polymers, capable penetrating stratum corneum without damaging underlying tissues. Upon insertion, HFMNs rapidly absorb interstitial fluid, swelling form hydrogel conduit that enables efficient transport directly into microcirculation. The nature enhances patient compliance by eliminating pain and discomfort associated with traditional hypodermic needles. This allows delivery wide range drugs, including macromolecules biomacromolecules, which are often difficult administer dermally due their size polarity. Moreover, provide controlled regulated release profiles, enabling sustained effects while minimizing systemic side effects. Additionally, can be used both real-time fluid monitoring, valuable insights disease states treatment responses. dual functionality positions versatile dermatology tool effectively addressing complications. review explores use polymeric biomaterials HFMN fabrication application major disorders, such acne, psoriasis, other skin Furthermore, highlights MN-based treatments, underscoring reduce improve adherence, supported recent literature.

Language: Английский

Citations

3
Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review DOI Creative Commons

Rashmi Hulimane Shivaswamy,

Pranav Binulal,

Aloysious Benoy

et al.

ACS Materials Au, Journal Year: 2024, Volume and Issue: 5(1), P. 115 - 140

Published: Nov. 28, 2024

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.

Language: Английский

Citations

0