Current Transplantation Reports, Journal Year: 2024, Volume and Issue: 11(2), P. 110 - 119
Published: April 23, 2024
Language: Английский
Cureus, Journal Year: 2023, Volume and Issue: unknown
Published: Aug. 21, 2023
Cardiovascular disease (CVD) is the primary cause of morbidity and mortality in individuals diagnosed with diabetes mellitus. This narrative review offers a comprehensive examination complex correlation between cardiovascular complications. The objective this to analyze most recent evidence on preventive measures treatment options for mitigating risk patients diabetes, by synthesizing existing literature. Insulin resistance plays crucial role connecting CVD, leading development dyslipidemia atherogenesis. As result, events significantly elevated. Moreover, presence hyperglycemia-induced oxidative stress inflammation serves intensify endothelial dysfunction vascular damage, thereby exacerbating interaction CVD frequently speeds up atherosclerotic plaque, making plaque more prone rupture. can lead severe such as myocardial infarction stroke. It comprehend intricate relationship order formulate effective strategies aimed at enhancing patient outcomes burden associated these interconnected chronic conditions. Healthcare practitioners enhance quality life reduce rates diabetic thoroughly examining evidence-based options. approach allows them make informed decisions when managing risk. In summary, provides valuable resource healthcare professionals researchers, presenting analysis CVD. By providing latest elucidating underlying mechanisms, seeks establish foundation innovative management. These have potential improve overall care.
Language: Английский
Citations
77
Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1390 - 1390
Published: June 23, 2024
Diabetic neuropathy (DN) is a neurodegenerative disorder that primarily characterized by distal sensory loss, reduced mobility, and foot ulcers may potentially lead to amputation. The multifaceted etiology of DN linked range inflammatory, vascular, metabolic, other factors. Chronic inflammation, endothelial dysfunction, oxidative stress are the three basic biological changes contribute development DN. Although our understanding intricacies has advanced significantly over past decade, distinctive mechanisms underlying condition still poorly understood, which be reason behind lack an effective treatment cure for present study delivers comprehensive highlights potential role several pathways molecular etiopathogenesis Moreover, Schwann cells satellite glial cells, as integral factors in pathogenesis DN, have been enlightened. This work will motivate allied research disciplines gain better analysis current state biomolecular essential effectively address every facet from prevention treatment.
Language: Английский
Citations
4
Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Language: Английский
Citations
0
International Wound Journal, Journal Year: 2025, Volume and Issue: 22(1)
Published: Jan. 1, 2025
Abstract This descriptive, cross‐sectional study aimed to identify whether having a chronic leg ulcer (CLU), in addition diabetes, contributed frailty individuals ≥65 years old. It also explored the associations between frailty, pre‐frailty and other factors. 125 participants aged attending outpatient clinics Ireland were categorised into three groups: (1) diabetes‐only no CLU, (2) CLU‐only (3) diabetes CLU. Frailty status was identified using Groningen Indicator (GFI) Physical Phenotype (PFP). The mean age 76.09 ± 7.31. Overall, 90 (72%) had 89 (71.2%) CLU past 6 months. While 124 (99.2%) frail according GFI, 122 (97.6%) either physically ( n = 40, 32%) or pre‐frail 82, 65.6%) based on PFP. There difference groups regarding general p > 0.05). However, being ≥75, associated with severity < Slow gait, inability go toilet dress/undress independently common factors contributing frailty. Age, comorbidities severity. Incorporating multidimensional screening regular clinic visits for older adults is recommended.
Language: Английский
Citations
0
Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 21, 2025
Frailty syndrome (FS) is a complex and multifaceted condition commonly observed in old adults patients with chronic diseases, often accompanied by cognitive impairments. This review explores the integration of frailty interventions into existing care models to improve patient outcomes, focusing on four key areas. First, it emphasizes importance comprehensive assessment tools identify impairments early, facilitating targeted planning. Second, highlights value personalized interventions, such as dietary modifications, exercise programs, training, tailored individual needs preferences. Third, underscores critical role multidisciplinary teams providing holistic coordinated care, leveraging expertise diverse healthcare professionals. Finally, examines potential technological innovations caregiver support systems enhancing management addressing challenges posed By integrating these approaches, this presents patient-centered framework aimed at mitigating impact improving long-term outcomes. The findings emphasize need for unified strategy that combines interdisciplinary collaboration, advancements address disease management.
Language: Английский
Citations
0
International Psychogeriatrics, Journal Year: 2025, Volume and Issue: unknown, P. 100034 - 100034
Published: Jan. 1, 2025
Depression is a chronic disorder that significantly affects functional decline in older adults, especially those with type 2 diabetes (T2D). Ethnic groups may experience different depression risks and severities, yet the effect of ethnicity on trajectories specific dimensions adults T2D remains largely unexamined. We examined longitudinal associations its over time Ashkenazi non-Ashkenazi Jews T2D. Generalized estimating equations (GEE) models were employed to analyze numbers depressive symptoms dimension, adjusting for sociodemographics, cognition, characteristics, cardiovascular risk factors. Community-dwelling from Israel Diabetes Cognitive Decline (IDCD) study. 902 Jews, mean age= 72.3 years. The Geriatric Scale-15 (GDS-15) five dimensions: Dysphoric Mood, Withdrawal Apathy-Lack Vigor, Anxiety, Hopelessness, Memory Complaint. At baseline, reported lower GDS-15 scores compared Jews. They exhibited Mood Hopelessness dimensions. GEE confirmed these findings, showing had total (β = 0.86, 95 % CI 0.75-0.99; p 0.03), 0.76 (0.52-0.90], 0.006), 0.74 [0.58-0.95], 0.017) rates clinical (OR= 0.68 [0.52-0.90], 0.006). These data offered no evidence difference trends between trajectories. Ethnicity associated Further investigation contributing factors, including social determinants health, essential.
Language: Английский
Citations
0
Current Diabetes Reports, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 26, 2025
Language: Английский
Citations
0
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118016 - 118016
Published: April 6, 2025
Language: Английский
Citations
0
Journal of Diabetes Science and Technology, Journal Year: 2024, Volume and Issue: 18(3), P. 577 - 583
Published: March 7, 2024
Objective: To assess the growing use of continuous glucose monitoring (CGM) systems by older adults and explore additional areas integration that could benefit with frailty. Background: The CGM devices has expanded rapidly in last decade. This been supported substantial data showing significant glycemic metrics: hemoglobin A1c improvements, less hypoglycemia, improved quality life. However, sub-populations, such as persons, exist where available are limited. Furthermore, frail represent a heterogeneous population their own unique challenges to management diabetes. group some poorest outcomes related sequela For example, hypoglycemia resulting morbidity mortality is more frequent person diabetes than younger persons Method: We present concise literature review on adult well expand upon nonglycemic benefits for patients, caregivers, providers. Retrospective analysis inpatient 16,935 Type 2 mellitus at Atrium Health Wake Forest Baptist indicated those fraility managed insulin or sulfonylurea had highest rates delirium (4.8%), (3.5%), cardiovascular complications (20.2%) ED visits/hospitalizatoins (49%). In addition, we address special consideration specific situations including inpatient, palliative long term care settings. Conclusion: article summarizes adults, discusses obstacles this population, identifies future research needed delivery
Language: Английский
Citations
3
Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)
Published: May 28, 2024
Abstract Background Several studies have focused on the impact of frailty health outcomes individuals with diabetes mellitus (DM). This meta-analysis aims to systematically synthesize existing evidence and its association mortality, hospitalizations, cardiovascular diseases, diabetic complications in DM. Methods A comprehensive search PubMed, Embase, SCOPUS was carried out identify relevant assessing complications, events The quality included evaluated using New Castle Ottawa Scale. Results From 22 included, our revealed significant associations between adverse pooled hazard ratios for mortality showed a substantial effect size 1.84 (95% CI 1.46–2.31). Similarly, odds ratio hospitalization demonstrated risk an 1.63 1.50–1.78). In addition, associated increased developing nephropathy (HR, 3.17; 95% 1.16–8.68) retinopathy 1.94; 0.80–4.71). Conclusion Our results show consistent link heightened rates, higher risks disease, nephropathy, patients PROSPERO Registration Number : CRD42023485166
Language: Английский
Citations
3