International Journal of Molecular Sciences,
Journal Year:
2018,
Volume and Issue:
19(10), P. 3028 - 3028
Published: Oct. 4, 2018
The
immense
diversity
of
extracellular
matrix
(ECM)
proteins
confers
distinct
biochemical
and
biophysical
properties
that
influence
cell
phenotype.
ECM
is
highly
dynamic
as
it
constantly
deposited,
remodelled,
degraded
during
development
until
maturity
to
maintain
tissue
homeostasis.
ECM’s
composition
organization
are
spatiotemporally
regulated
control
behaviour
differentiation,
but
dysregulation
dynamics
leads
the
diseases
such
cancer.
chemical
cues
presented
by
have
been
appreciated
key
drivers
for
both
cancer
progression.
However,
mechanical
forces
present
due
largely
ignored
recently
recognized
play
critical
roles
in
disease
progression
malignant
behaviour.
Here,
we
review
ways
which
microenvironment
regulation
phenotype
stages
human
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: May 27, 2021
The
tumor
microenvironment
(TME)
is
a
complex
and
ever-changing
“rogue
organ”
composed
of
its
own
blood
supply,
lymphatic
nervous
systems,
stroma,
immune
cells
extracellular
matrix
(ECM).
These
components,
utilizing
both
benign
malignant
cells,
nurture
the
harsh,
immunosuppressive
nutrient-deficient
environment
necessary
for
cell
growth,
proliferation
phenotypic
flexibility
variation.
An
important
aspect
TME
cellular
crosstalk
cell-to-ECM
communication.
This
interaction
induces
release
soluble
factors
responsible
evasion
ECM
remodeling,
which
further
contribute
to
therapy
resistance.
Other
aspects
are
presence
exosomes
contributed
by
circulating
deregulated
microRNAs
TME-specific
metabolic
patterns
potentiate
progression
and/or
resistance
therapy.
In
addition
biochemical
signaling,
specific
characteristics
such
as
hypoxic
environment,
derangements,
abnormal
mechanical
forces
have
been
implicated
in
development
treatment
this
review,
we
will
provide
an
overview
microenvironmental
composition,
structure,
features
that
influence
suppression
Physiological Reviews,
Journal Year:
2020,
Volume and Issue:
100(4), P. 1707 - 1751
Published: April 16, 2020
Pancreatic
ductal
adenocarcinoma
(PDAC)
belongs
to
the
most
lethal
solid
tumors
in
humans.
A
histological
hallmark
feature
of
PDAC
is
pronounced
tumor
microenvironment
(TME)
that
dynamically
evolves
during
progression.
The
TME
consists
different
non-neoplastic
cells
such
as
cancer-associated
fibroblasts,
immune
cells,
endothelial
and
neurons.
Furthermore,
abundant
extracellular
matrix
components
collagen
hyaluronic
acid
well
matricellular
proteins
create
a
highly
dynamic
hypovascular
with
multiple
biochemical
physical
interactions
among
various
cellular
acellular
promote
progression
therapeutic
resistance.
In
recent
years,
intensive
research
efforts
have
resulted
significantly
improved
understanding
biology
pathophysiology
PDAC,
novel
stroma-targeted
approaches
are
emerging
may
help
improve
devastating
prognosis
patients.
However,
none
anti-stromal
therapies
has
been
approved
patients
so
far,
there
still
large
discrepancy
between
successful
preclinical
results
subsequent
failure
clinical
trials.
findings
suggest
parts
also
possess
tumor-restraining
properties
rendering
tailored
even
more
challenging.
Frontiers in Oncology,
Journal Year:
2020,
Volume and Issue:
9
Published: Jan. 17, 2020
Cancer
metastasis
is
the
dissemination
of
tumor
cells
to
new
sites,
resulting
in
formation
secondary
tumors.
This
process
complex
and
spatially
temporally
regulated
by
intrinsic
extrinsic
factors.
One
important
factor
extracellular
matrix,
non-cellular
component
tissues.
Heparan
sulfate
proteoglycans
(HSPGs)
are
constituents
through
their
heparan
chains
protein
core,
modulate
multiple
events
that
occur
during
metastatic
cascade.
review
will
provide
an
overview
role
matrix
cancer
metastasis,
primarily
focusing
on
perlecan.
Perlecan,
a
basement
membrane
HSPG
key
vascular
commonly
associated
with
Its
contradictory
these
be
discussed
we
highlight
recent
advances
therapies
target
HSPGs
modifying
enzymes.
