Tumor microenvironment complexity and therapeutic implications at a glance

Cell Communication and Signaling, Journal Year: 2020, Volume and Issue: 18(1)

Published: April 7, 2020

Abstract The dynamic interactions of cancer cells with their microenvironment consisting stromal (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity cell, clonal evolution increase multidrug resistance ending in cell progression metastasis. reciprocal cell-cell/ECM interaction tumor hijacking non-malignant force lose function acquire new phenotypes that promote development invasion cells. Understanding underlying cellular molecular mechanisms governing these can be used as a novel strategy indirectly disrupt interplay contribute efficient safe therapeutic strategies fight cancer. Furthermore, tumor-derived circulating materials also diagnostic tools precisely predict monitor outcome therapy. This review evaluates such potentials various advanced models, focus on 3D systems well lab-on-chip devices.

Language: Английский

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Tumor Microenvironment

Medicina, Journal Year: 2019, Volume and Issue: 56(1), P. 15 - 15

Published: Dec. 30, 2019

The tumor microenvironment has been widely implicated in tumorigenesis because it harbors cells that interact with surrounding through the circulatory and lymphatic systems to influence development progression of cancer. In addition, nonmalignant play critical roles all stages carcinogenesis by stimulating facilitating uncontrolled cell proliferation.This study aims explore concept conducting a review previous studies on topic. Materials Methods: This relies evidence presented related articles included this were obtained from different medical health databases.The received significant attention cancer literature, particular focus its role progression. Previous have identified various components malignant behavior addition cells, adipocytes, fibroblasts, vasculature, lymphocytes, dendritic cancer-associated fibroblasts are present microenvironment. Each these types unique immunological capabilities determine whether will survive affect neighboring cells.The stem other molecules contribute Consequently, targeting manipulating factors during treatment can help control malignancies achieve positive outcomes.

Language: Английский

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How the ageing microenvironment influences tumour progression

Nature reviews. Cancer, Journal Year: 2019, Volume and Issue: 20(2), P. 89 - 106

Published: Dec. 13, 2019

Language: Английский

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The extracellular matrix in tumor progression and metastasis

Clinical & Experimental Metastasis, Journal Year: 2019, Volume and Issue: 36(3), P. 171 - 198

Published: April 11, 2019

Language: Английский

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Extracellular Matrix Alterations in Metastatic Processes

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(19), P. 4947 - 4947

Published: Oct. 7, 2019

The extracellular matrix (ECM) is a complex network of extracellular-secreted macromolecules, such as collagen, enzymes and glycoproteins, whose main functions deal with structural scaffolding biochemical support cells tissues. ECM homeostasis essential for organ development functioning under physiological conditions, while its sustained modification or dysregulation can result in pathological conditions. During cancer progression, epithelial tumor may undergo epithelial-to-mesenchymal transition (EMT), morphological functional remodeling, that deeply alters cell features, leading to loss markers (i.e., E-cadherin), changes polarity intercellular junctions increase mesenchymal N-cadherin, fibronectin vimentin). This process enhances detachment from the original mass invasiveness, which are necessary metastasis onset, thus allowing enter bloodstream lymphatic flow colonize distant sites. mechanisms lead metastases specific sites still largely obscure but modifications occurring target tissue being intensively studied. Matrix metalloproteases several adhesion receptors, among integrins play key role, involved metastasis-linked modifications. In addition, metastatic niche formation, like associated fibroblasts (CAF) macrophages (TAM), have been found crucial roles alterations aimed at promoting growth. this review we focus on molecular during progression dissemination sites, special attention lung, liver bone. Moreover, role forming will also be reviewed light most recent findings.

Language: Английский

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stLearn: integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: May 31, 2020

ABSTRACT Spatial Transcriptomics is an emerging technology that adds spatial dimensionality and tissue morphology to the genome-wide transcriptional profile of cells in undissociated tissue. Integrating these three types data creates a vast potential for deciphering novel biology cell their native morphological context. Here we developed innovative integrative analysis approaches utilise all first find types, then reconstruct type evolution within tissue, search regions with high cell-to-cell interactions. First, normalisation gene expression, compute distance measure using similarity neighbourhood smoothing. The normalised used clusters represent profiles specific cellular phenotypes. Clusters are further sub-clustered if spatially separated. Analysing anatomical mouse brain sections 12 human datasets, found clustering method more accurate sensitive than other methods. Second, introduce calculate states by pseudo-space-time (PST) distance. PST function physical (spatial distance) expression (pseudotime estimate pairwise between among We transition gradients connected locally cluster, or globally clusters, directed minimum spanning tree optimisation approach algorithm could model from non-invasive invasive breast cancer dataset. Third, information identify locations where there both ligand-receptor interaction activity diverse co-localisation. These predicted be hotspots cell-cell interactions likely occur. detected pairs significantly enriched compared background distribution across Together, algorithms, implemented comprehensive Python software stLearn, allow elucidation biological processes healthy diseased tissues.

Language: Английский

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Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis

F1000Research, Journal Year: 2020, Volume and Issue: 9, P. 229 - 229

Published: April 2, 2020

Oral squamous cell carcinoma (OSCC) is a commonly occurring head and neck cancer. It has high prevalence in certain parts of the world, associated with mortality rate. In this review, we describe metastasis related to OSCC, disorders that could lead OSCC common etiological factors. addition, brief account diagnosis role salivary biomarkers its early detection also been highlighted. Google Scholar PubMed search engines were searched keywords including "oral carcinoma", "OSCC", cancer", "potentially malignant oral cavity", "etiological factors OSCC", "diagnosis "salivary OSCC" gather literature for review. The review concludes potential regional as well distant metastasis, many potentially diseases can transform into help various Diagnosis involves traditional biopsy, but be utilized recognition.

Language: Английский

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Tumor microenvironment components: Allies of cancer progression

Pathology - Research and Practice, Journal Year: 2019, Volume and Issue: 216(1), P. 152729 - 152729

Published: Nov. 11, 2019

Language: Английский

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Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 2, 2023

Abstract Despite centuries since the discovery and study of cancer, cancer is still a lethal intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as pivotal component tumor microenvironment. The versatility sophisticated mechanisms CAFs in facilitating progression been elucidated extensively, including promoting angiogenesis metastasis, inducing drug resistance, reshaping extracellular matrix, developing an immunosuppressive Owing to their robust tumor-promoting function, are considered promising target for oncotherapy. However, highly heterogeneous group cells. Some subpopulations exert inhibitory role growth, which implies that CAF-targeting approaches must be more precise individualized. This review comprehensively summarize origin, phenotypical, functional heterogeneity CAFs. More importantly, we underscore advances strategies clinical trials CAF various cancers, also progressions immunotherapy.

Language: Английский

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Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: March 1, 2021

Cancer is a disease which frequently has poor prognosis. Although multiple therapeutic strategies have been developed for various cancers, including chemotherapy, radiotherapy, and immunotherapy, resistance to these treatments impedes the clinical outcomes. Besides active driven by genetic epigenetic alterations in tumor cells, microenvironment (TME) also reported be crucial regulator tumorigenesis, progression, resistance. Here, we propose that adaptive mechanisms of are closely connected with TME rather than depending on non-cell-autonomous changes response treatment. comprehensive understanding need further investigation fully elucidate resistance, many targeting successful. In this review, report recent advances concerning molecular events important factors involved TME, particularly focusing contributions provide insights into potential methods or translational medicine overcome therapy

Language: Английский

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