International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1470 - 1470
Published: Jan. 12, 2023
The
intestinal
barrier,
with
its
multiple
layers,
is
the
first
line
of
defense
between
outside
world
and
intestine.
Its
disruption,
resulting
in
increased
permeability,
a
recognized
pathogenic
factor
extra-intestinal
diseases.
identification
gut-vascular
barrier
(GVB),
consisting
structured
endothelium
below
epithelial
layer,
has
led
to
new
evidence
on
etiology
management
diseases
gut-liver
axis
gut-brain
axis,
recent
implications
oncology
as
well.
involved
several
neuroinflammatory
processes.
In
particular,
description
choroid
plexus
vascular
regulating
brain
permeability
under
conditions
gut
inflammation
identifies
key
regulator
maintaining
tissue
homeostasis
health.
Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: March 1, 2022
Primary
open-angle
glaucoma
progression
is
associated
with
increased
human
trabecular
meshwork
(HTM)
stiffness
and
elevated
transforming
growth
factor
beta
2
(TGFβ2)
levels
in
the
aqueous
humor.
Increased
transcriptional
activity
of
Yes-associated
protein
(YAP)
coactivator
PDZ-binding
motif
(TAZ),
central
players
mechanotransduction,
are
implicated
glaucomatous
HTM
cell
dysfunction.
Yet,
detailed
mechanisms
underlying
YAP/TAZ
modulation
cells
response
to
alterations
extracellular
matrix
(ECM)
TGFβ2
not
well
understood.
Using
biomimetic
ECM
hydrogels
tunable
stiffness,
here
we
show
that
elevates
nuclear
localization
potentially
through
modulating
focal
adhesions
cytoskeletal
rearrangement.
Furthermore,
both
normal
cells,
which
was
prevented
by
inhibiting
extracellular-signal-regulated
kinase
Rho-associated
signaling
pathways.
Filamentous
(F)-actin
depolymerization
reversed
TGFβ2-induced
localization.
depletion
using
siRNA
or
verteporfin
decreased
adhesions,
remodeling
contractile
properties.
Similarly,
inactivation
partially
blocked
hydrogel
contraction
stiffening.
Collectively,
our
data
provide
evidence
for
a
pathologic
role
aberrant
dysfunction,
may
help
inform
strategies
development
novel
multifactorial
approaches
prevent
progressive
ocular
hypertension
glaucoma.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Feb. 11, 2023
Abstract
Prolonged
lung
pathology
has
been
associated
with
COVID-19,
yet
the
cellular
and
molecular
mechanisms
behind
this
chronic
inflammatory
disease
are
poorly
understood.
In
study,
we
combine
advanced
imaging
spatial
transcriptomics
to
shed
light
on
local
immune
response
in
severe
COVID-19.
We
show
that
activated
adventitial
niches
crucial
microenvironments
contributing
orchestration
of
prolonged
immunopathology.
Up-regulation
chemokines
CCL21
CCL18
associates
endothelial-to-mesenchymal
transition
tissue
fibrosis
within
these
niches.
over-expression
additionally
links
accumulation
T
cells
expressing
cognate
receptor
CCR7.
These
imprinted
an
exhausted
phenotype
form
lymphoid
aggregates
can
organize
ectopic
structures.
Our
work
proposes
immune-stromal
interaction
promoting
a
self-sustained
non-resolving
extends
beyond
active
viral
infection
perpetuates
remodeling.
Neurobiology of Disease,
Journal Year:
2023,
Volume and Issue:
178, P. 106028 - 106028
Published: Feb. 1, 2023
Multiple
sclerosis
is
an
inflammatory
demyelinating
disease
of
the
central
nervous
system
(CNS)
and
most
common
non-traumatic
cause
neurological
disability
in
young
adults.
clinical
care
has
improved
considerably
due
to
development
disease-modifying
therapies
that
effectively
modulate
peripheral
immune
response
reduce
relapse
frequency.
However,
current
treatments
do
not
prevent
neurodegeneration
progression,
efforts
multiple
will
be
hampered
so
long
as
this
remains
unknown.
Risk
factors
for
or
severity
include
vitamin
D
deficiency,
cigarette
smoking
youth
obesity,
which
also
impact
vascular
health.
People
with
frequently
experience
blood-brain
barrier
breakdown,
microbleeds,
reduced
cerebral
blood
flow
diminished
neurovascular
reactivity,
it
possible
these
pathologies
are
tied
development.
The
unit
a
cellular
network
controls
neuroinflammation,
maintains
integrity,
tightly
regulates
flow,
matching
energy
supply
neuronal
demand.
composed
vessel-associated
cells
such
endothelial
cells,
pericytes
astrocytes,
however
other
glial
cell
types
comprise
niche.
Recent
single-cell
transcriptomics
data,
indicate
particular
microvasculature,
compromised
within
lesions.
Large-scale
genetic
small-scale
biology
studies
suggest
dysfunction
could
primary
pathology
contributing
Herein
we
revisit
risk
pathophysiology
highlight
known
potential
roles
progression.
We
evaluate
suitability
target
future
modifying
sclerosis.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1470 - 1470
Published: Jan. 12, 2023
The
intestinal
barrier,
with
its
multiple
layers,
is
the
first
line
of
defense
between
outside
world
and
intestine.
Its
disruption,
resulting
in
increased
permeability,
a
recognized
pathogenic
factor
extra-intestinal
diseases.
identification
gut-vascular
barrier
(GVB),
consisting
structured
endothelium
below
epithelial
layer,
has
led
to
new
evidence
on
etiology
management
diseases
gut-liver
axis
gut-brain
axis,
recent
implications
oncology
as
well.
involved
several
neuroinflammatory
processes.
In
particular,
description
choroid
plexus
vascular
regulating
brain
permeability
under
conditions
gut
inflammation
identifies
key
regulator
maintaining
tissue
homeostasis
health.
