Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: Feb. 16, 2021

The Notch signaling pathway plays an essential role in a wide variety of biological processes including cell fate determination vascular endothelial cells and the regulation arterial differentiation angiogenesis. is also regulator tumor growth survival by functioning as either oncogene or suppressor context-dependent manner. Crosstalk between other pathways pivotal progression promoting cancer growth, migration, invasion, metastasis, angiogenesis, expansion stem (CSCs). In this review, we provide overview update functioning, progression, particularly development CSCs therapeutic resistance. We further summarize recent studies on how crosstalk with contributes to angiogenesis CSCs, thereby providing insights into biology within microenvironment progression.

Language: Английский

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A long way to go: caspase inhibitors in clinical use

Cell Death and Disease, Journal Year: 2021, Volume and Issue: 12(10)

Published: Oct. 15, 2021

Abstract Caspases are an evolutionary conserved family of cysteine-dependent proteases that involved in many vital cellular processes including apoptosis, proliferation, differentiation and inflammatory response. Dysregulation caspase-mediated apoptosis inflammation has been linked to the pathogenesis various diseases such as diseases, neurological disorders, metabolic cancer. Multiple caspase inhibitors have designed synthesized a potential therapeutic tool for treatment cell death-related pathologies. However, only few progressed clinical trials because consistent challenges faced amongst different types used pathologies, namely inadequate efficacy, poor target specificity, or adverse side effects. Importantly, large proportion this failure lies lack understanding functions. To overcome current challenges, further studies on function disease model is fundamental requirement effectively develop their Therefore, present review focuses descriptive properties characteristics known date, application animal studies. In addition, brief discussion achievements, faced, presented support providing more perspectives development successful diseases.

Language: Английский

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Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 189, P. 114504 - 114504

Published: Aug. 23, 2022

Language: Английский

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Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(9)

Published: Sept. 4, 2023

Abstract The tumor microenvironment (TME) is a highly intricate milieu, comprising multitude of components, including immune cells and stromal cells, that exert profound influence on initiation progression. Within the TME, angiogenesis predominantly orchestrated by endothelial (ECs), which foster proliferation metastasis malignant cells. interplay between with ECs complex can either bolster or hinder system. Thus, comprehensive understanding crosstalk essential to advance development immunotherapeutic interventions. Despite recent progress, underlying molecular mechanisms govern remain elusive. Nevertheless, immunomodulatory function has emerged as pivotal determinant response. In light this, study relationship checkpoints garnered considerable attention in field immunotherapy. By targeting specific pathways signaling molecules associated novel strategies may be devised enhance efficacy current treatments. this vein, we sought elucidate ECs, ultimate goal identifying therapeutic targets charting new avenues for

Language: Английский

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Endothelial cells in tumor microenvironment: insights and perspectives

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 15, 2024

The tumor microenvironment is a highly complex and dynamic mixture of cell types, including tumor, immune endothelial cells (ECs), soluble factors (cytokines, chemokines, growth factors), blood vessels extracellular matrix. Within this network, ECs are not only relevant for controlling fluidity permeability, orchestrating angiogenesis but also regulating the antitumor response. Lining luminal side vessels, check passage molecules into compartment, regulate cellular transmigration, interact with both circulating pathogens innate adaptive cells. Thus, they represent first-line defense system that participates in responses. Tumor-associated involved T priming, activation, proliferation by acting as semi-professional antigen presenting targeting may assist improving functions. Moreover, tumor-associated contribute to development at site tertiary lymphoid structures, which have recently been associated enhanced response checkpoint inhibitors (ICI). When compared normal ECs, abnormal terms phenotype, genetic expression profile, They characterized high proliferative potential ability activate immunosuppressive mechanisms support progression metastatic dissemination. A complete phenotypic functional characterization could be helpful clarify their role within identify EC specific drug targets improve cancer therapy. emerging therapeutic strategies based on combination anti-angiogenic treatments immunotherapy strategies, ICI, CAR bispecific antibodies aim impact block same time increase recruitment activation effector tumor.

Language: Английский

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Broadening horizons: molecular mechanisms and disease implications of endothelial-to-mesenchymal transition

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 9, 2025

Endothelial-mesenchymal transition (EndMT) is defined as an important process of cellular differentiation by which endothelial cells (ECs) are prone to lose their characteristics and transform into mesenchymal cells. During EndMT, reduced expression adhesion molecules disrupts intercellular adhesion, triggering cytoskeletal reorganization transition. Numerous studies have proved that EndMT a multifaceted biological event driven primarily cytokines such TGF-β, TNF-α, IL-1β, alongside signaling pathways like WNT, Smad, MEK-ERK, Notch. Nevertheless, the exact roles in complicated diseases not been comprehensively reviewed. In this review, we summarize predominant molecular regulatory mechanisms contribute development well highlight contributions series imperative non-coding RNAs curbing initiation EndMT. Furthermore, discuss significant impact on worsening vasculature-related diseases, including cancer, cardiovascular atherosclerosis, pulmonary vascular diabetes-associated fibrotic conditions, cerebral cavernous malformation, providing implications targeting holds promise therapeutic strategy mitigate disease progression.

Language: Английский

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Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease

FEBS Journal, Journal Year: 2021, Volume and Issue: 289(21), P. 6484 - 6517

Published: June 18, 2021

The characterization of fibro/adipogenic progenitor cells (FAPs) in the skeletal muscle has contributed to modify monocentric view regeneration beyond satellite (MuSCs). Now, we are aware that each population niche plays a critical role modulating homeostasis and regeneration. In healthy muscle, FAPs contribute maintain tissue assist MuSCs cope with limited insults. Here, sense integrate signals keep check their differentiation potential. disruption these cues leads FAP into adipocytes fibroblasts, both detrimental hallmarks large variety wasting diseases. biology is still its infancy, current efforts focused on understanding molecular circuits governing double-edged behavior. present review offers detailed overview pathways metabolic routes can be modulated halt redirect potential while favoring supportive Finally, discuss how single-cell technologies have resolve transitional states distinctive roles myopathies.

Language: Английский

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Mutational insights into the envelope protein of SARS-CoV-2

Gene Reports, Journal Year: 2020, Volume and Issue: 22, P. 100997 - 100997

Published: Dec. 8, 2020

Language: Английский

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Cerebral Vessels: An Overview of Anatomy, Physiology, and Role in the Drainage of Fluids and Solutes

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 13, 2021

The cerebral vasculature is made up of highly specialized structures that assure constant brain perfusion necessary to meet the very high demand for oxygen and glucose by neurons glial cells. A dense, redundant network arteries spread over entire pial surface from which penetrating dive into cortex reach neurovascular units. Besides providing blood parenchyma, are key in drainage interstitial fluid (ISF) solutes such as amyloid-beta. This occurs along basement membranes surrounding vascular smooth muscle cells, toward leptomeningeal deep cervical lymph nodes. dense microvasculature fine capillaries. Capillary walls contain pericytes have contractile properties lined a blood–brain barrier regulates entry ions maintains integrity composition ISF. They also important production Capillaries drain venules course centrifugally cortical veins empty dural venous sinuses. sinuses home meningeal lymphatic vessels support cerebrospinal fluid, although pathways still poorly understood. Damage macro- will compromise perfusion, hamper synchronized movement neurofluids, affect waste products leading neuronal degeneration. review present anatomy, their role dynamics, summary how dysfunction can lead neurodegeneration.

Language: Английский

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Challenges of SERS technology as a non-nucleic acid or -antigen detection method for SARS-CoV-2 virus and its variants

Biosensors and Bioelectronics, Journal Year: 2021, Volume and Issue: 181, P. 113153 - 113153

Published: March 9, 2021

Language: Английский

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