Talanta, Journal Year: 2023, Volume and Issue: 267, P. 125080 - 125080
Published: Aug. 17, 2023
Language: Английский
Exploration, Journal Year: 2023, Volume and Issue: 3(1)
Published: Jan. 7, 2023
Coronavirus disease 2019 (COVID-19) pandemic has exemplified how viral growth and transmission are a significant threat to global biosecurity. The early detection treatment of infections is the top priority prevent fresh waves control pandemic. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) been identified through several conventional molecular methodologies that time-consuming require high-skill labor, apparatus, biochemical reagents but have low accuracy. These bottlenecks hamper methods from resolving COVID-19 emergency. However, interdisciplinary advances in nanomaterials biotechnology, such as nanomaterials-based biosensors, opened new avenues for rapid ultrasensitive pathogens field healthcare. Many updated namely electrochemical, field-effect transistor, plasmonic, colorimetric employ nucleic acid antigen-antibody interactions SARS-CoV-2 highly efficient, reliable, sensitive, manner. This systematic review summarizes mechanisms characteristics biosensors detection. Moreover, continuing challenges emerging trends biosensor development also discussed.
Language: Английский
Citations
51
ChemistryOpen, Journal Year: 2023, Volume and Issue: 12(1)
Published: Jan. 1, 2023
Surface-enhanced Raman spectroscopy (SERS) has shown strength in non-invasive, rapid, trace analysis and been used many fields medicine. Machine learning (ML) is an algorithm that can imitate human styles structure existing content with the knowledge to effectively improve efficiency. Integrating SERS ML have a promising future medical field. In this review, we summarize applications of combined recent years, such as recognition biological molecules, rapid diagnosis diseases, developing new immunoassay techniques, enhancing capabilities semi-quantitative measurements. Ultimately, possible opportunities challenges combining are addressed.
Language: Английский
Citations
47
Sensors and Actuators B Chemical, Journal Year: 2021, Volume and Issue: 351, P. 130897 - 130897
Published: Oct. 12, 2021
Language: Английский
Citations
84
ACS Sensors, Journal Year: 2022, Volume and Issue: 7(11), P. 3470 - 3480
Published: Nov. 14, 2022
In early 2022, the number of people infected with highly contagious mutant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), called Omicron, was increasing worldwide. Therefore, several countries approved lateral flow assay (LFA) strip as a diagnostic method for confirming SARS-CoV-2 instead reverse transcription-polymerase chain reaction (RT-PCR), which takes long time to generate results. However, owing limitation detection sensitivity, commercial LFA strips have high false-negative diagnosis rates patients low virus concentrations. in this study, we developed portable surface-enhanced Raman scattering (SERS)-LFA reader based on localized surface plasmon effects solve sensitivity problem strip. We tested 54 clinical samples using SERS-LFA reader, generated 49 positive and 5 negative Out results, classified only false negative, while 21 negative. This confirmed that rate had significantly improved compared strips. believe proposed system can be utilized point-of-care quickly accurately determine infection could spread within short period.
Language: Английский
Citations
56
Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 365, P. 131974 - 131974
Published: April 28, 2022
Language: Английский
Citations
50
Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 213, P. 114442 - 114442
Published: May 31, 2022
Language: Английский
Citations
45
Biosensors, Journal Year: 2022, Volume and Issue: 12(7), P. 466 - 466
Published: June 28, 2022
COVID-19 continues to spread and has been declared a global emergency. Individuals with current or past infection should be identified as soon possible prevent the of disease. Surface-enhanced Raman spectroscopy (SERS) is an analytical technique that potential used detect viruses at site therapy. In this context, SERS exciting because it provides fingerprint for any material. It many virus subtypes, including Deltacron Omicron, novel coronavirus. Moreover, flexible substrates, due their unique advantages sensitivity flexibility, have recently attracted growing research interest in real-world applications such medicine. Reviewing latest SERS-substrate developments crucial further development quality detection platforms. This article discusses ultra-responsive methods by substrate. Multiplex assays combine biomarkers and/or secondary diseases triggered are critical, according study. addition, we discuss how SERS-substrate-based ultrasensitive could transform disease diagnosis, control, surveillance future. study believed help researchers design manufacture substrates higher performance lower cost, ultimately better understand practical applications.
Language: Английский
Citations
45
The Analyst, Journal Year: 2022, Volume and Issue: 147(12), P. 2809 - 2818
Published: Jan. 1, 2022
The reality that the coronavirus disease 2019 (COVID-19) is still raging around world and making a comeback with strong presence has highlighted need for rapid sensitive quantitative detection methods of viral RNA, antibody antigen widespread tracking screening applications. Surface plasmon resonance (SPR) technology achieved development become standard measurement method in fields biosensing, biomedicine, biochemistry biopharmaceuticals due to its advantages high sensitivity, fast response no labelling. Here, we report sandwiched structure-based SPR biosensor detecting specific antigen, severe acute respiratory syndrome 2 (SARS-CoV-2) spike S1 protein. sensor combines Ti3C2-MXene nanosheet modified sensing platform polydopamine (PDA)-Ag nanoparticle (AgNP)/anti-SARS-CoV-2 protein nanoconjugate signal enhancers, exhibiting wide linear range 0.0001 1000 ng mL-1 low limit 12 fg (S/N = 3). In analysis artificial saliva human serum samples, proposed exhibits good reproducibility specificity, which indicates potential application complex bodily fluids. exploitation MXene-based biochip recognizing SARS-CoV-2 provides an accessible way COVID-19 diagnosis, promotes 2D nanomaterial-based chips clinical diagnosis screening. Significantly, possesses general applicability can be reprogrammed detect any if corresponding nanobody available.
Language: Английский
Citations
43
Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 615 - 627
Published: July 3, 2023
Language: Английский
Citations
38
Biophysical Reviews, Journal Year: 2023, Volume and Issue: 15(2), P. 199 - 221
Published: April 1, 2023
Abstract Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has detection of viruses. Here we review various techniques employed investigation Different are discussed including conventional spectroscopy, surface-enhanced tweezer, tip-enhanced Spectroscopy, coherent anti-Stokes scattering. Surface-enhanced scattering can play an essential role in viral by multiplexing nanotechnology, microfluidics, machine learning ensuring spectral reproducibility efficient workflow sample processing detection. The application these to diagnose SARS-CoV-2 virus is also reviewed. Graphical abstract
Language: Английский
Citations
29