Polyphenols: Natural Food-Grade Biomolecules for the Treatment of Nervous System Diseases from a Multi-Target Perspective DOI Creative Commons

Xinchen Wu,

Yang Zhou, Yujiang Xi

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 775 - 775

Published: June 13, 2024

Polyphenols are the most prevalent naturally occurring phytochemicals in human diet and range complexity from simple molecules to high-molecular-weight polymers. They have a broad of chemical structures generally categorized as “neuroprotective”, “anti-inflammatory”, “antioxidant” given their main function halting disease onset promoting health. Research has shown that some polyphenols metabolites can penetrate blood–brain barrier hence increase neuroprotective signaling neurohormonal effects provide anti-inflammatory antioxidant effects. Therefore, multi-targeted modulation may prevent progression neuropsychiatric disorders new practical therapeutic strategy for difficult-to-treat disorders. multi-target potential such nervous system diseases. Herein, we review benefits on autism-spectrum disorders, anxiety depression, sleep along with vitro ex vivo experimental clinical trials. Although methods action still under investigation, seldom employed directly agents Comprehensive mechanistic investigations large-scale multicenter randomized controlled trials required properly evaluate safety, effectiveness, side polyphenols.

Language: Английский

SIRT1: A Potential Therapeutic Target in Autoimmune Diseases DOI Creative Commons
Pan Shen, Xuan Deng, Zhe Chen

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 23, 2021

The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide, the identification novel therapeutic strategies for prevention treatment is urgently needed. Sirtuin 1 (SIRT1), a member class III family nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylases, has reported to participate in progression several diseases. SIRT1 also regulates inflammation, oxidative stress, mitochondrial function, immune responses, cellular differentiation, proliferation metabolism, its altered functions are likely involved Ads. Several inhibitors activators shown affect development may represent target these diseases, small molecules or natural products that modulate potential agents. In present review, we summarize current studies biological role pathogenesis

Language: Английский

Citations

108
Mechanisms of endocrine therapy resistance in breast cancer DOI Creative Commons
Fahmida Rasha, Monica Sharma, Kevin Pruitt

et al.

Molecular and Cellular Endocrinology, Journal Year: 2021, Volume and Issue: 532, P. 111322 - 111322

Published: May 15, 2021

The most commonly diagnosed breast cancer (BC) subtype is characterized by estrogen receptor (ER) expression. Treatment of this BC typically involves modalities that either suppress the production or impede binding estrgen to its receptors, constituting basis for endocrine therapy. While many patients have benefitted from therapy with clear reduction in mortality and recurrence, one clinical hurdles remain overcoming intrinsic (de novo) acquired resistance driven diverse complex changes occurring tumor microenvironment. Moreover, such may persist even after progression through additional antiestrogen therapies thus demonstrating importance further investigation mechanisms ER modulation. Here, we discuss a number advances provide better understanding mechanistic as well future therapeutic maneuvers break resistance.

Language: Английский

Citations

65
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases DOI Creative Commons

Chenxi Lu,

Huadong Zhao,

Yanqing Liu

et al.

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 19(2), P. 484 - 501

Published: Dec. 19, 2022

Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent deacetylase, is cellular that has received extensive attention in recent years and regarded as sensor of energy metabolism. The accumulated evidence suggests SIRT1 involved the development endocrine metabolic diseases. In variety organisms, regulates gene expression through deacetylation histone, transcription factors, lysine residues other modified proteins including several signal thereby enhancing therapeutic effects These evidences indicate targeting promising applications treatment This review focuses on role First, we describe background structure SIRT1. Then, outline diseases such hyperuricemia, diabetes, hypertension, hyperlipidemia, osteoporosis, polycystic ovarian syndrome. Subsequently, agonists inhibitors above are summarized future research directions proposed. Overall, presents here may highlight potential biomarker target for

Language: Английский

Citations

65
The role of Sirtuin 1 and its activators in age-related lung disease DOI Open Access

Chaoqun Sun,

Shuyou Bai,

Yanmei Liang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114573 - 114573

Published: April 3, 2023

Aging is a major driving factor in lung diseases. Age-related disease associated with downregulated expression of SIRT1, an NAD+-dependent deacetylase that regulates inflammation and stress resistance. SIRT1 acts by inducing the deacetylation various substrates several mechanisms relate to aging, such as genomic instability, stem cell exhaustion, mitochondrial dysfunction, telomere shortening, immune senescence. Chinese herbal medicines have many biological activities, exerting anti-inflammatory, anti-oxidation, anti-tumor, regulatory effects. Recent studies confirmed herbs effect activating SIRT1. Therefore, we reviewed mechanism age-related explored potential roles activators treatment disease.

Language: Английский

Citations

14
Ceruloplasmin correlates with immune infiltration and serves as a prognostic biomarker in breast cancer DOI Creative Commons
Fei Chen,

Bihui Han,

Yanxiu Meng

et al.

Aging, Journal Year: 2021, Volume and Issue: 13(16), P. 20438 - 20467

Published: Aug. 19, 2021

Breast-invasive carcinoma (BRCA) is the most frequent and malignant tumor in females. Ceruloplasmin (CP) a multifunctional molecule involved iron metabolism, but its expression profile, prognostic potential relationship with immune cell infiltration BRCA are unknown. mRNA protein was significantly decreased patients according to Oncomine, UALCAN, GEPIA TCGA databases. strongly correlated various clinicopathological features of patients. high ceruloplasmin exhibited shorter survival times than those low based on Kaplan-Meier plotter PrognoScan GO KEGG analyses GSEA revealed strong correlation between immune-related pathways. associated cells into sites by analyzing TIMER CIBERSORT. Additionally, positively checkpoints BRCA. These findings suggest that correlates favorable prognosis may serve as therapeutic target predict efficacy immunotherapy for

Language: Английский

Citations

29
Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis DOI Creative Commons
Yi Chen,

Hefang Xiao,

Zirui Liu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 970 - 970

Published: Aug. 8, 2024

Osteoporosis (OP) is a common metabolic bone disease characterized by low mass, decreased mineral density, and degradation of tissue microarchitecture. However, our understanding the mechanisms remodeling factors affecting mass remains incomplete. Sirtuin1 (SIRT1) nicotinamide adenine dinucleotide-dependent deacetylase that regulates variety cellular metabolisms, including inflammation, tumorigenesis, metabolism. Recent studies have emphasized important role SIRT1 in homeostasis. This article reviews metabolism OP also discusses therapeutic strategies future research directions for targeting SIRT1.

Language: Английский

Citations

4
Regulation of aromatase in cancer DOI

Deborah Molehin,

Fahmida Rasha, Rakhshanda Layeequr Rahman

et al.

Molecular and Cellular Biochemistry, Journal Year: 2021, Volume and Issue: 476(6), P. 2449 - 2464

Published: Feb. 18, 2021

Language: Английский

Citations

25
Sirtuins in kidney homeostasis and disease: where are we now? DOI Creative Commons

Zhongyu Fan,

Xuejiao Wei, Xiaoyu Zhu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

Sirtuins, identified as (NAD + )- dependent class III histone deacetylases, engage in a spectrum of biological functions, encompassing DNA damage repair, oxidative stress, immune modulation, mitochondrial homeostasis, apoptosis and autophagy. Sirtuins play an role regulating cellular operations overall organism health. Mounting data indicate that dysregulated sirtuin expression is linked to the onset renal diseases. Effective modulation sirtuins activity has been shown improve function attenuate advancement kidney In this review, we present comprehensive overview impacts their molecular targets Additionally, detail advancements elucidating roles pathophysiology both chronic acute disorders. We review compounds modulate through activation or inhibition, potentially improving outcomes disease. summary, strategic manipulation represents prospective therapeutic approach for

Language: Английский

Citations

0
Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD DOI Creative Commons
Yao Xu, Tianxiao Hu,

Peiwu Jiang

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 29, 2025

Introduction Sirtuin 1, a class III histone deacetylase, plays critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation inhibiting osteoclast maturation. However, its exact impact on mineral density (BMD) type 2 (T2DM) remains unclear. This study investigates relationship between 1 levels, BMD, newly diagnosed T2DM patients, specifically examining alterations levels those with concomitant osteoporosis or osteopenia. Methods A total 69 patients 82 control subjects normal glucose tolerance (NGT) were enrolled. Serum turnover markers, including osteocalcin (OC), procollagen N-terminal propeptide (P1NP), β-C-terminal telopeptide I collagen (β-CTX), measured using enzyme-linked immunosorbent assay (ELISA). BMD was assessed via dual-energy X-ray absorptiometry (DXA). Comparisons these parameters made NGT groups. Results further categorized into group (DMn) an osteopenia (DMo), differences subgroups analyzed. Risk factors for osteoporosis/osteopenia also evaluated. found to be significantly diminished relative (P < 0.05), no significant lumbar spine OC, 25(OH)D, β-CTX groups > 0.05). Osteoporosis incidence higher compared controls (34.8% vs. 18.3%, P = 0.026). Subgroup analysis revealed that SIRT1 exhibited reduction Logistic regression indicated age, HDL-C, P1NP, independent risk patients. Discussion In conclusion, decreased serum are associated markers may serve as factor potential biomarker diagnosing disorders

Language: Английский

Citations

0
Olmesartan attenuates doxorubicin-elicited testicular toxicity: The interaction between sirtuin-1, HMGB1/NLRP3 inflammasome/gasdermin D signaling, and AMPK/mTOR-driven autophagy DOI
Hemat A. Elariny,

Hanan Abdelmawgoud Atia,

Marwa H. Abdallah

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123545 - 123545

Published: March 1, 2025

Language: Английский

Citations

0