Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2237 - 2237

Published: Nov. 13, 2022

Inflammation of the human lung is mediated in response to different stimuli (e.g., physical, radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental pollutants. They often promote an increase inflammatory activities airways that manifest themselves chronic diseases allergic airway diseases, asthma, bronchitis/chronic obstructive pulmonary disease (COPD) even cancer). Increased levels oxidative stress (OS) reduce antioxidant defenses, affect autophagy/mitophagy processes, regulatory mechanisms cell survival, promoting inflammation lung. In fact, OS potentiate lung, favoring progression diseases. increases production reactive oxygen species (ROS), including superoxide anions (O2-), hydroxyl radicals (OH) hydrogen peroxide (H2O2), by transformation through enzymatic non-enzymatic reactions. this manner, reduces endogenous defenses both nucleated non-nucleated cells. The ROS can derive from exogenous insults (cigarette pollution) sources injury and/or activated structural review, we describe most relevant knowledge concerning functional interrelation between

Language: Английский

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MYB transcription factors—master regulators of phenylpropanoid biosynthesis and diverse developmental and stress responses

Plant Cell Reports, Journal Year: 2022, Volume and Issue: 41(12), P. 2245 - 2260

Published: Sept. 29, 2022

Language: Английский

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Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

Food Chemistry X, Journal Year: 2022, Volume and Issue: 15, P. 100414 - 100414

Published: Aug. 8, 2022

Fungi, as the unique natural resource, are rich in polysaccharides, proteins, fats, vitamins, and other components. Therefore, they have good medical nutritional values. Polysaccharides considered one of most important bioactive components fungi. Increasing researches confirmed that fungal polysaccharides various biological activities, such antioxidant, immunomodulatory, anti-tumor, hepatoprotective, anti-aging, anti-inflammatory, radioprotective activities. Consequently, research progresses future prospects must be systematically reviewed to promote their better understanding. This paper extraction, purification, structure, activity, underlying molecular mechanisms polysaccharides. Moreover, structure–activity relationships were emphasized discussed. review can provide scientific basis for industrial utilization

Language: Английский

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The hyperfunction theory: An emerging paradigm for the biology of aging

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 74, P. 101557 - 101557

Published: Jan. 3, 2022

Language: Английский

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Mortality Attributable to Ambient Air Pollution: A Review of Global Estimates

GeoHealth, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 20, 2022

Abstract Since the publication of first epidemiological study to establish connection between long‐term exposure atmospheric pollution and effects on human health, major efforts have been dedicated estimate attributable mortality burden, especially in context Global Burden Disease (GBD). In this work, we review estimates excess outdoor air at global scale, by comparing studies available literature. We find large differences estimates, which are related response functions as well number health outcomes included calculations, aspects where further improvements necessary. Furthermore, show that despite considerable advancements our understanding impacts consequent improvement accuracy their precision has not increased last decades. offer recommendations for future measurements research directions, will help improve quantification pollution‐health relationships.

Language: Английский

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Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: April 14, 2023

Abstract Redox homeostasis refers to the balance between production of reactive oxygen species (ROS) as well nitrogen (RNS), and their elimination by antioxidants. It is linked all important cellular activities oxidative stress a result imbalance pro-oxidants antioxidant species. Oxidative perturbs many activities, including processes that maintain integrity DNA. Nucleic acids are highly therefore particularly susceptible damage. The DNA damage response detects repairs these lesions. Efficient repair essential for maintaining viability, but they decline considerably during aging. deficiencies in increasingly described age-related neurodegenerative diseases, such Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis Huntington’s disease. Furthermore, has long been associated with conditions. Moreover, both redox dysregulation increase significantly aging, which biggest risk factor diseases. However, links dysfunction damage, joint contributions pathophysiology conditions, only just emerging. This review will discuss associations address increasing evidence an major source disorders. Understanding connections may facilitate better understanding disease mechanisms, ultimately lead design therapeutic strategies based on preventing

Language: Английский

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COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14876 - 14876

Published: Oct. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Language: Английский

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ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

Science, Journal Year: 2023, Volume and Issue: 382(6675)

Published: Dec. 7, 2023

The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment activation. Conversely, zebrafish larvae deficient for are protected from ROS-induced pathology. Livers mice fed ROS-generating diet exhibit ZAKα-activating changes elongation dynamics. Highlighting role RSR metabolic regulation, ZAK-knockout developing high-fat high-sugar (HFHS) diet-induced blood glucose intolerance liver steatosis. Finally, ZAK ablation slows animals hallmarks aging. Our work highlights as physiological activation signal underlies adaptation obesity

Language: Английский

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Neural modulation with photothermally active nanomaterials

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(3), P. 193 - 207

Published: Jan. 31, 2023

Language: Английский

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Protective Effects of Sulforaphane Preventing Inflammation and Oxidative Stress to Enhance Metabolic Health: A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 428 - 428

Published: Jan. 24, 2025

The worldwide obesity epidemic has led to a drastic increase in diabetes and cardiovascular disease younger generations. Further, maintaining metabolic health during aging is frequently challenge due poor diets decreased mobility. In this setting, bioactive nutrients that are naturally occurring antioxidants, such as sulforaphane (SFN), of high nutritional interest. SFN, compound present cruciferous vegetables, molecule protects cells from cytotoxic damage mitigates oxidative stress, protecting against disease. It exerts its action through the activation transcription factor nuclear erythroid 2-related 2 (Nrf2). Many studies have been performed animals humans evaluate effects on cancer, brain health, neurodegenerative disorders. However, fewer clinical insulin resistance development type mellitus (T2DM) across lifespan. Given that, some parts world, particularly Europe, population growing older at significant rate, it crucial promote healthy habits (healthy foods, dietary pattern, precision nutrition, physical activity) an early stage life lifespan avoid debilitating conditions adulthood aging. Thus, narrative review, we discuss protective SFN supplementation inflammatory stress pathways relate them

Language: Английский

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