Green synthesis of magnesium nanoparticles mediated from Rosa floribunda charisma extract and its antioxidant, antiaging and antibiofilm activities

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Aug. 19, 2021

Abstract Flower based nanoparticles has gained a special attention as new sustainable eco-friendly avenue. Rosa floribunda charisma belongs to modern roses with bright yellow, red flowers marvellous rose scent. Different methods were used for the extraction of its floral scent such hexane, microwave, and solid-phase micro-extraction. The latter was most efficient method phenyl ethyl alcohol, unique roses. In current study, magnesium (RcNps) have been synthesized using petals that privileges beyond chemical physical routs. RcNps formation confirmed UV–Visible (UV–Vis) Spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), High Resolution-Transmission Electron Microscope (HR-TEM), Field Emission-Scanning (FE-SEM), Energy dispersive X-ray (EDX), Diffractometer (XRD), photoelectron spectroscopy (XPS). HR-TEM images detected polyhedral shape diverse size ranged within 35.25–55.14 nm. resulting exhibited high radical scavenging activity illustrated by inhibition superoxide, nitric oxide, hydroxyl xanthine oxidase IC 50 values 26.2, 52.9, 31.9 15.9 µg/ml respectively compared ascorbic acid. Furthermore, at concentration 100 significantly reduced (15.9 ± 0.61 µg/ml) acid (12.80 0.32 p < 0.05. Moreover, showed an excellent antiaging demonstrated collagenase, elastase, hyaluronidase tyrosinase enzymes in dose-dependent manner 58.7 1.66 µg/ml, 82.5 2.93 191.4 5.68 158.6 5.20 EGCG respectively. also, promising antibacterial against three skin pathogens delineate significant threat public health, Staphylococcus epidermidis , Streptococcus pyogenes Pseudomonas aeruginosa MIC 15.63, 7.81, 31.25 ciprofloxacin (7.81, 3.9 15.63 µg/ml). suppressed biofilms minimum biofilm inhibitory concentrations 1.95, 7.81 fore mentioned strains, Overall, our findings indicate could be leading natural source care cosmetic industry.

Language: Английский

---

The Thioredoxin System of Mammalian Cells and Its Modulators

Biomedicines, Journal Year: 2022, Volume and Issue: 10(7), P. 1757 - 1757

Published: July 21, 2022

Oxidative stress involves the increased production and accumulation of free radicals, peroxides, other metabolites that are collectively termed reactive oxygen species (ROS), which produced as by-products aerobic respiration. ROS play a significant role in cell homeostasis through redox signaling capable eliciting damage to macromolecules. Multiple antioxidant defense systems have evolved prevent dangerous body, with glutathione thioredoxin/thioredoxin reductase (Trx/TrxR) being most important. The Trx/TrxR system has been used target treat cancer thiol–disulfide exchange reaction mechanism results reduction wide range proteins generation oxidized Trx. TrxR maintains reduced Trx levels using NADPH co-substrate; therefore, efficiently homeostasis. Being master regulator oxidation–reduction processes, Trx-dependent is associated proliferation survival. Herein, we review structure catalytic properties system, its cellular connection systems, factors modulate system.

Language: Английский

---

Application of titanium dioxide nanoparticles in photothermal and photodynamic therapy of cancer: An updated and comprehensive review

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 75, P. 103605 - 103605

Published: July 19, 2022

Language: Английский

---

NF-κB, a culprit of both inflamm-ageing and declining immunity?

Immunity & Ageing, Journal Year: 2022, Volume and Issue: 19(1)

Published: May 17, 2022

NF-κB is generally recognized as an important regulator of ageing, through its roles in cellular senescence and inflammatory pathways. Activated virtually all cell-cell communication networks the immune system, thought to affect age-related defects both innate adaptive cells, relevant inflamm-ageing declining immunity, respectively. Moreover, family proteins that exist heterodimers homodimers exert their function beyond system. Given involvement diverse areas such DNA damage metabolism, has potential serve linkages between known hallmarks ageing. However, complexity dimer composition, dynamic signaling, tissue-specific actions received relatively little attention ageing research. Here, we discuss some where further research may bear fruit our understanding impact healthy longevity.

Language: Английский

---

Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature

Drug Design Development and Therapy, Journal Year: 2022, Volume and Issue: Volume 16, P. 2919 - 2931

Published: Aug. 1, 2022

Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, is known to have anti-inflammatory and anti-oxidant effects on the brain, its clinical potential in treatment of cognitive impairment diseases such as Alzheimer's disease (AD) Parkinson (PD) currently being explored. This review focused reported beneficial pioglitazone dysfunction summarized associated mechanisms with pioglitazone-induced improvement dysfunction. Our relevant literature indicated that there conclusive evidence effect improving via agonistic PPAR-γ. Further, several action been reported, these include enhanced NF-kB p38 activity; regulation pro-inflammatory cytokines IL-1, IL-6, TNF-α; inhibition Aβ production; alterations levels mitochondrial proteins mitoNEET; protein kinases CDK5 JNK; ROS MDA antioxidant TRX1 PON2; increased expression thyroid hormone receptors. Despite promising findings, also cardiovascular risks, weight gain edema, which subsequently increase risk mortality. it has documented may be unable cross blood-brain barrier when administered certain forms, can cause cell death at high concentrations. Therefore, further research required explore acute chronic memory function order determine applicability disorders. Nonetheless, current does demonstrate promotes PPAR receptors ameliorating inflammation, oxidative stress, amyloidogenesis, hypothyroidism, enhancing neurogenesis, synaptic plasticity, function. warrant investigation establish disorders, PD AD, neuronal conditions diabetes.

Language: Английский

---

Reactive oxygen species in cancer progression and its role in therapeutics

Exploration of Medicine, Journal Year: 2022, Volume and Issue: unknown, P. 43 - 57

Published: Feb. 22, 2022

The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above cellular tolerability threshold results apoptotic or necrotic cell death. belongs to a group highly compounds that have evolved play key roles signaling pathways. It’s widely assumed reasonable amount essential for variety biological processes. Elevated levels are known cause various pathologic conditions like neurological disorders, cardiovascular conditions, inflammation, autoimmunity, cancer. well initiate assist progression tumor promoting proliferation survival cancer cells thus facilitates pro-tumorigenic microenvironment. As become more resilient effects manipulating drugs, increased antioxidant capacity attenuates susceptibility treatment. Excessive environmental stress, on other hand, can die. This review summarizes molecular mechanisms including role checkpoint inhibitors be harnessed develop effective therapeutic strategies targeting related

Language: Английский

---

Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101941 - 101941

Published: April 29, 2023

While aging was traditionally viewed as a stochastic process of damage accumulation, it is now clear that strongly influenced by genetics. The identification and characterization long-lived genetic mutants in model organisms has provided insights into the pathways molecular mechanisms involved extending longevity. Long-lived exhibit activation multiple stress response leading to enhanced resistance exogenous stressors. As result, lifespan exhibits significant, positive correlation with stress. Disruption inhibits extension representing different can also reduce wild-type animals. Combined, this suggests key mechanism which achieve their extended longevity many these are required for normal lifespan. These results highlight an important role determining organism.

Language: Английский

---

Role of NF-κB during Mycobacterium tuberculosis Infection

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1772 - 1772

Published: Jan. 16, 2023

Mycobacterium tuberculosis (M. tb) causes infection in humans worldwide, especially among immunocompromised populations and areas of the world with insufficient funding for treatment. Specifically, M. tb is predominantly exhibited as a latent infection, which poses greater risk reactivation infected individuals. It has been previously shown that requires pro-inflammatory anti-inflammatory mediators to manage its associated granuloma formation via tumor necrosis factor-α (TNF-α), interleukin-12 (IL-12), interferon-γ (IFN-γ), caseum IL-10, respectively. Nuclear factor κ-light-chain-enhancer activated B cells (NF-κB) found play unique mediator role providing response chronic inflammatory disease processes by promoting activation macrophages release various cytokines such IL-1, IL-6, IL-12, TNF-α. NF-κB's interesting mechanism assisting immune system's defense against tb, wherein NF-κB induces IL-2 receptors (IL-2R) decrease response, but also crucially assist keeping bacterial load contained. In order understand reducing within this literature review we will discuss dynamic interaction between NF-κB, focus on intracellular signaling pathways possible side effects inactivation infection. Through thorough these interactions, aims highlight purpose better understanding complex uncover further potential therapeutic methods.

Language: Английский

---

The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 496 - 496

Published: March 27, 2023

Natural product derivatives are essential in searching for compounds with important chemical, biological, and medical applications. Naphthoquinones secondary metabolites found plants used traditional medicine to treat diverse human diseases. Considering this, the synthesis of naphthoquinone has been explored contain potential biological activity. It reported that chemical modification naphthoquinones improves their pharmacological properties by introducing amines, amino acids, furan, pyran, pyrazole, triazole, indole, among other groups. In this systematic review, we summarized preparation nitrogen discussed effect associated redox mechanisms. Preclinical evaluation antibacterial and/or antitumoral is included because cancer a worldwide health problem, there lack effective drugs against multidrug-resistant bacteria. The information presented herein indicates could be considered further studies provide efficient treating

Language: Английский

---

Socialized mitochondria: mitonuclear crosstalk in stress

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(5), P. 1033 - 1042

Published: May 1, 2024

Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that signaling organelles involved in intracellular interactions with other organelles. Remarkably, stressed appear to induce a beneficial response restores mitochondrial function and cellular homeostasis. These stress-centered pathways been rapidly elucidated multiple organisms. In this review, we examine current perspectives on how communicate the rest cell, highlighting mitochondria-to-nucleus (mitonuclear) communication under various stresses. Our understanding as may provide new insights into disease susceptibility lifespan extension.

Language: Английский

---