New perspectives on arteriosclerosis treatment using nanoparticles and mesenchymal stem cells

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(8)

Published: July 29, 2024

Abstract Arteriosclerosis (AS) presents a significant global health challenge, demanding innovative therapeutic strategies. This review explores the potential of nanoparticles (NPs) and mesenchymal stem cells (MSCs) as promising modalities for treating AS. NPs enable targeted drug delivery, while MSCs possess immunomodulatory regenerative capabilities. We discuss recent advances in NP-based delivery systems tailored AS treatment highlight MSCs’ roles modulating inflammation promoting vascular repair. Additionally, we examine synergistic effects combining enhanced outcomes. Furthermore, this paper provides insights into targeting endothelial cells, T-cells, macrophages, lipid levels, plaques using MSCs. It also reviews various types metal-based non-metallic utilized therapy. comprehensive overview underscores synergies between cardiovascular disease therapy, emphasizing need further research to fully realize their implications. Graphical

Language: Английский

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Precision Nanomedicine with Bio-Inspired Nanosystems: Recent Trends and Challenges in Mesenchymal Stem Cells Membrane-Coated Bioengineered Nanocarriers in Targeted Nanotherapeutics

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(3), P. 827 - 872

Published: June 24, 2024

In the recent past, formulation and development of nanocarriers has been elaborated into broader fields opened various avenues in their preclinical clinical applications. particular, cellular membrane-based nanoformulations have formulated to surpass surmount limitations restrictions associated with naïve or free forms therapeutic compounds circumvent physicochemical immunological barriers including but not limited systemic barriers, microenvironmental roadblocks, other subcellular hinderances-which are quite heterogeneous throughout diseases patient cohorts. These drug delivery overcome through mesenchymal cells precision therapeutics, where these interventions led significant enhancements efficacies. However, still focuses on optimization paradigms a one-size-fits-all resolutions. As stem cell engineered highly diversified fashions, being optimized for delivering payloads more better personalized modes, entering arena as well nanomedicine. this Review, we included some advanced which designed utilized both non-personalized applicability can be employed improvements nanotherapeutics. present report, authors focused aspects advancements nanoparticle conceptions several roadblocks It suggested that well-informed designing will lead appreciable efficacy payload approaches also enable tailored customized designs MSC-based applications, finally amending outcomes.

Language: Английский

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Cellular therapeutic potential of genetically engineered stem cells in cancer treatment

Biotechnology and Genetic Engineering Reviews, Journal Year: 2023, Volume and Issue: 40(4), P. 4062 - 4097

Published: May 3, 2023

Traditional therapeutic approaches in the treatment of cancer have many side effects and are often ineffective non-specific, leading to development therapy-resistant tumour cells. Recently, numerous discoveries about stem cells given a new outlook on their application oncology. Stem unique because biological attributes, including self-renewal, differentiation different types specialized synthesis molecules that interplay with niche. They already used as an effective option for haematological malignancies, such multiple myeloma leukaemia. The main goal this study is investigate possible applications summarize novel advances, well limitations treatment. Research clinical trials underway revealed confirmed enormous potential regenerative medicine cancer, especially when combined nanomaterials. Nanoengineering has been focus studies area medicine, production nanoshells nanocarriers enhance transport uptake targeted niche enable monitoring cell Although nanotechnology lot limitations, it provides opportunities innovative therapies.

Language: Английский

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Alginate Nanoparticles: A Potential Drug Carrier in Tuberculosis Treatment

Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 207 - 234

Published: Jan. 1, 2023

Language: Английский

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Gold Mesoporous Silica-Coated Nanoparticles for Quantifying and Qualifying Mesenchymal Stem Cell Distribution; a Proof-of-Concept Study in Large Animals

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Mesenchymal stem cells (MSCs) have demonstrated promising therapeutic potential across a wide range of diseases including (multi) organ injury in neonates. Despite the reported preclinical successes MSC therapy, major challenge their clinical translation is limited understanding biodistribution after administration. This knowledge gap needs to be addressed allow implementation. Accordingly, this study, we propose that silica-coated gold nanoparticles (AuMS) are tool for vivo tracing. study explores use AuMS both qualitative and quantitative tracking intravenous (I.V.) administration translational ovine model preterm birth. Additionally, assess impact labeling on immunomodulatory functions MSC, which play an important role potency these cells. Quantitative assessment AuMS-labeled was performed using fluorescent microscopy inductively coupled plasma mass spectrometry (ICP-MS), respectively. localization liver, spleen, lung demonstrated. In vitro studies showed cellular uptake occurs within 6 h remains internalized up 72 h. Labeled maintained immune phenotype did not alter capacity proliferation abilities. Overall, demonstrate promising, biocompatible nanoprobe tracing post-I.V.

Language: Английский

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Near-infrared fluorescent nanoprobe enables noninvasive, longitudinal monitoring of graft outcome in RPE transplantation

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 9, 2025

Objectives Retinal pigment epithelium (RPE) cell transplantation holds therapeutic promise for retinal degenerative diseases, but longitudinal monitoring of graft survival and efficacy remains clinically challenging. The aim this study is to develop a simple effective method the quantification RPE immune rejection in vivo . Methods A nanoprobe was developed modified label donor cells, used monitor position intensity fluorescence signal Immunofluorescence staining single-cell RNA sequencing (scRNA-seq) were characterize types showing determine composition microenvironment associated with subretinal transplantation. Results spatial distribution corresponded site transplantation, decreased over time, while extended choroid. Additionally, detected liver spleen during long-term monitoring. Conversely, mice administered immunosuppressive drug cyclosporine A, decrease slower expansion less pronounced. analysis revealed significant temporal increase proportion macrophages nanoprobe-labeled cells following stability cell-penetrating ability enables labeling niches scRNA-seq identified MDK ANXA1 signaling pathway as initiators cascade, which further amplified by macrophage-mediated pro-inflammatory signaling. Conclusion Near-infrared fluorescent nanoprobes represent reliable tracing observation can be evaluate degree rejection. Molecular facilitates characterization dynamic niche landscape donor-host interactions

Language: Английский

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Molecular and cellular imaging of the eye

Biomedical Optics Express, Journal Year: 2023, Volume and Issue: 15(1), P. 360 - 360

Published: Dec. 11, 2023

The application of molecular and cellular imaging in ophthalmology has numerous benefits. It can enable the early detection diagnosis ocular diseases, facilitating timely intervention improved patient outcomes. Molecular techniques help identify disease biomarkers, monitor progression, evaluate treatment responses. Furthermore, these allow researchers to gain insights into pathogenesis diseases develop novel therapeutic strategies. also basic research elucidate normal physiological processes occurring within eye, such as cell signaling, tissue remodeling, immune By providing detailed visualization at level, contribute a comprehensive understanding biology. Current clinically available often relies on confocal microscopy, multi-photon PET (positron emission tomography) or SPECT (single-photon computed techniques, optical coherence tomography (OCT), fluorescence imaging. Preclinical focuses identification targets for various diseases. aim is discover specific biomarkers pathways associated with allowing targeted precise characterization. In parallel, efforts are being made sophisticated multifunctional contrast agents that selectively bind identified targets. These enhance signal improve sensitivity specificity by carrying labels, including radionuclides SPECT, fluorescent dyes imaging, nanoparticles multimodal advancements technology instrumentation pursued multimodality Integrating different modalities, PET/MRI (magnetic resonance imaging) PET/CT (computed tomography), allows complementary strengths each modality be combined, anatomical information single examination. Recently, photoacoustic microscopy (PAM) been explored retinal PAM non-invasive, non-ionizing radiation, hybrid combines excitation ultrasound detection. offers unique approach both functional information. Its ability utilize molecularly holds great promise applications ophthalmology. this review, we will summarize tracking chorioretinal angiogenesis along migration stem cells after subretinal transplantation vivo .

Language: Английский

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Unlocking the Mysteries, Bridging the Gap, and Unveiling the Multifaceted Potential of Stem Cell Therapy for Cardiac Tissue Regeneration: A Narrative Review of Current Literature, Ethical Challenges, and Future Perspectives

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: July 7, 2023

Revolutionary advancements in regenerative medicine have brought stem cell therapy to the forefront, offering promising prospects for regeneration of ischemic cardiac tissue. Yet, its full efficacy, safety, and role treating heart disease (IHD) remain limited. This literature review explores intricate mechanisms underlying therapy. Furthermore, we unravel innovative approaches employed bolster survival, enhance differentiation, seamlessly integrate them within tissue microenvironment. Our comprehensive analysis uncovers how cells promote angiogenesis, modulate immune response. Stem harnesses a multifaceted mode action, encompassing paracrine effects direct replacement. As our progresses, underscore imperative standardized protocols, preclinical clinical studies, careful regulatory considerations. Lastly, explore integration engineering genetic modifications, envisioning future where reigns supreme medicine.

Language: Английский

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Innovative nanotechnology tools for the functional control and tracking of human stem cells

Materials Today Advances, Journal Year: 2022, Volume and Issue: 16, P. 100298 - 100298

Published: Sept. 19, 2022

The precise control of stem cell behavior, including differentiation, transdifferentiation, and reprogramming, is fundamental for safely efficiently using human cells in regenerative medicine. Thanks to recent innovations developments the field nanomedicine, as well its integration with advanced molecular biology approaches, possibility engineering restoring functions complex tissues become reality. Multifunctional nanotechnological tools allow finely release growth factors, mRNA, other molecules, promote fate conversion, perform long-term tracking vivo. Furthermore, stimulation approaches based on smart biocompatible nanotransducers promise remotely modulate activity, paving way actual exploitation these technologies internal large-sized animals. In this review, most innovative nanotechnology applied cell-based medicine are presented, their implications future research clinics discussed.

Language: Английский

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Stem cell transplantation therapy for advanced liver damage -associated neurodegenerative disorders

International Journal of Surgery, Journal Year: 2024, Volume and Issue: 110(11), P. 6873 - 6882

Published: July 23, 2024

Hepatic encephalopathy and other neurodegenerative disorders have profound implications for extensive liver impairment, calling new ways of treating the condition. The application stem cell transplantation to treat these severe is a encouraging technique. This review article digs deep into subject therapy, associated with advanced damage, transplantation. It comprehensively analyses background, rationale, scope, objectives using cells such challenging conditions. topic discussion includes subtleties disorders, function transplantation, possible advantages disadvantages it. relevance patient selection, intraoperative concerns post-transplant care discussed. Further, explores how cell-based therapies can benefit from nanotechnology, specifically it improve distribution, survival, integration better therapeutic results. aims offer thorough analysis regenerative medicine's present future possibilities in dealing intricate relationship between neurodegeneration damage. does this by examining efficacy, safety, long-term impacts will incorporate insights ongoing clinical trials, patent landscape, directions. goal pave way innovative personalized treatment approaches evolving research practice field. Therefore, efforts represent promising frontier medical that alleviate burden HE neurological complications combined cirrhosis.

Language: Английский

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