Nanotechnology for Nasopharyngeal Cancer Therapy and Improving Drug Stability and Biodistribution DOI

Minmin Shao,

Madineh Moradialvand, Francesca Della Sala

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract Nasopharyngeal cancer (NPC) is a challenging malignancy with poor prognosis due to late diagnosis and resistance conventional treatments. Nanotechnology offers promising solutions address these limitations by enabling targeted drug delivery, enhancing therapeutic efficacy, facilitating multimodal treatment strategies. By leveraging the unique properties of nanomaterials nanocarrier systems, innovative approaches for early detection, treatment, therapy can be developed, paving way more effective personalized management NPC. This review provides comprehensive overview recent developments applications nanotechnology in NPC therapy, focusing on improving stability, biodistribution, delivery tumors.

Language: Английский

Lipid-based nanoparticles: innovations in ocular drug delivery DOI Creative Commons
Mirza Salman Baig,

Shweta Kulkarni Karade,

Anas Ahmad

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 17, 2024

Ocular drug delivery presents significant challenges due to intricate anatomy and the various barriers (corneal, tear, conjunctival, blood-aqueous, blood-retinal, degradative enzymes) within eye. Lipid-based nanoparticles (LNPs) have emerged as promising carriers for ocular their ability enhance solubility, improve bioavailability, provide sustained release. LNPs, particularly solid lipid (SLNs), nanostructured (NLCs), cationic (CNLCs), solutions enhancing delivery. This review provides a comprehensive summary of nanoparticle-based systems, emphasizing biocompatibility efficiency in applications. We evaluated research articles sourced from databases such Google Scholar, TandFonline, SpringerLink, ScienceDirect, focusing on studies published between 2013 2023. The discusses materials methodologies employed preparation SLNs, NLCs, CNLCs, application proficient particular, demonstrate superior effectiveness attributed electrostatic bioadhesion tissues, However, continued efforts are essential further optimize CNLC formulations validate clinical utility, ensuring advancements technology improved patient outcomes.

Language: Английский

Citations

8
Nanotechnology-Assisted mesenchymal stem cells treatment for improved cartilage regeneration: A review of current practices DOI

Hongming Lin,

Chao Zhou, Qingping Li

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116895 - 116895

Published: March 1, 2025

Language: Английский

Citations

0
Mesenchymal stem cell exosomes therapy for the treatment of traumatic brain injury: mechanism, progress, challenges and prospects DOI Creative Commons
Ming-wei Liu, Hua Li,

Gang Xiong

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 11, 2025

Language: Английский

Citations

0
In situ Gel: A Promising Ocular Drug Delivery System DOI Open Access

Javed Khan,

Aatif Khan,

Aman Khan

et al.

International Journal of Advancement in Life Sciences Research, Journal Year: 2024, Volume and Issue: 07(03), P. 65 - 77

Published: Jan. 1, 2024

The eye is a vital organ, faces challenges in drug delivery with traditional ophthalmic formulations due to the rapid loss of medications before reaching cornea. This review explores novel systems for ocular administration, emphasizing innovative dosage forms, i.e., situ gels. system aims prolong contact time eyes, overcoming bioavailability issues associated conventional methods. article further delves into gelation approaches, highlighting pH-triggered, temperature-dependent, and ion-activated systems. It use excipients like polymers solubilizing agents preparation in-situ frequently used their applications are detailed. Studies on incorporation nanoparticles this gelling delivery. Methodologies evaluating gels, including pH determination, rheological studies, content analysis, vitro gelation, accelerated stability FTIR presented. advantages & gels discussed, along its limitations. concludes by benefits systems, particularly which offer controlled sustained release, future perspective gel. These advancements hold promise more effective therapeutic outcomes field

Language: Английский

Citations

0
Nanotechnology for Nasopharyngeal Cancer Therapy and Improving Drug Stability and Biodistribution DOI

Minmin Shao,

Madineh Moradialvand, Francesca Della Sala

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract Nasopharyngeal cancer (NPC) is a challenging malignancy with poor prognosis due to late diagnosis and resistance conventional treatments. Nanotechnology offers promising solutions address these limitations by enabling targeted drug delivery, enhancing therapeutic efficacy, facilitating multimodal treatment strategies. By leveraging the unique properties of nanomaterials nanocarrier systems, innovative approaches for early detection, treatment, therapy can be developed, paving way more effective personalized management NPC. This review provides comprehensive overview recent developments applications nanotechnology in NPC therapy, focusing on improving stability, biodistribution, delivery tumors.

Language: Английский

Citations

0