The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

Biomimetics, Journal Year: 2022, Volume and Issue: 7(3), P. 87 - 87

Published: July 1, 2022

The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in all human tissues. It comprised of varying proteins, including collagens, elastin, smaller quantities structural proteins. Studies have demonstrated the ECM aids cellular adherence, tissue anchoring, signaling, recruitment cells. During times integumentary injury or damage, either acute chronic, damaged. Through series overlapping events called wound healing phases—hemostasis, inflammation, proliferation, remodeling—the synthesized ideally returned to its native state. This article synthesizes current historical literature demonstrate involvement phases cascade.

Language: Английский

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The role of short-chain fatty acids in inflammatory skin diseases

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 2, 2023

Short-chain fatty acids (SCFAs) are metabolites of gut microbes that can modulate the host inflammatory response, and contribute to health homeostasis. Since introduction gut-skin axis concept, link between SCFAs skin diseases has attracted considerable attention. In this review, we have summarized literature on role in inflammation, correlation diseases, especially atopic dermatitis, urticaria, psoriasis. Studies show signaling factors alleviate inflammation. The information presented review provides new insights into molecular mechanisms driving regulation, along with possible pathways be targeted for treatment prevention diseases.

Language: Английский

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Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 2, 2024

Abstract Tactile function is essential for human life as it enables us to recognize texture and respond external stimuli, including potential threats with sharp objects that may result in punctures or lacerations. Severe skin damage caused by severe burns, cancer, chemical accidents, industrial accidents the structure of tissue well nerve system, resulting permanent tactile sensory dysfunction, which significantly impacts an individual’s daily life. Here, we introduce a fully-implantable wireless powered system embedded artificial (WTSA), stable operation, restore permanently damaged promote wound healing regenerating severely skin. The fabricated WTSA facilitates (i) replacement broad biocompatibility, (ii) promoting regeneration through collagen fibrin-based (CFAS), (iii) minimization foreign body reaction via hydrogel coating on neural interface electrodes. Furthermore, shows operation evidenced quantitative analysis leg movement angle electromyogram (EMG) signals response varying intensities applied pressures.

Language: Английский

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The Metabolic Syndrome, a Human Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251

Published: Feb. 13, 2024

This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.

Language: Английский

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Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 185 - 202

Published: March 5, 2024

Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose multi-functional composite hydrogel engineered overcome such conditions through recruitment and activation macrophages with adapted degradation the hydrogel. The (G-TSrP) is created by combining gelatin methacryloyl (GelMA) nanoparticles (TSrP) composed tannic acid (TA) Sr2+. These are prepared using one-step mineralization process assisted metal-phenolic network formation. G-TSrP exhibits ability eliminate reactive oxygen species direct polarization toward M2 phenotype. It has been observed that liberation TA Sr2+ from actively facilitate up-regulation expression extracellular matrix remodeling genes macrophages, thereby, coordinate vivo G-TSrP. Most significantly, accelerates angiogenesis despite TA's inhibitory properties, which counteracted released Moreover, enhances wound closure under promotes normal tissue formation strong vessel growth. Genetic analysis confirms macrophage-mediated Collectively, these findings pave way for development biomaterials promote creating regenerative environment.

Language: Английский

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Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 1, 2024

The extracellular matrix (ECM) is a highly complex structure through which biochemical and mechanical signals are transmitted. In processes of cell migration, the ECM also acts as scaffold, providing structural support to cells well points potential attachment. Although well-studied structure, its role in many biological remains difficult investigate comprehensively due complexity variation within an organism. tandem with experiments, mathematical models helpful refining testing hypotheses, generating predictions, exploring conditions outside scope experiments. Such can be combined calibrated vivo vitro data identify critical cell-ECM interactions that drive developmental homeostatic processes, or progression diseases. this review, we focus on computational such migration including cancer metastasis, tissue morphogenesis. By highlighting predictive power these models, aim help bridge gap between experimental approaches studying provide guidance selecting appropriate model framework complement corresponding studies.

Language: Английский

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Towards a comprehensive definition of the human fascial system

Journal of Anatomy, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract The absence of a clear consensus on the definition and significance fascia indiscriminate use term throughout clinical scientific literature has led to skepticism regarding its importance in human body. To address this challenge, we propose that: (1) fasciae, fascial interstitia within them, constitute an anatomical system, defined as layered body‐wide multiscale network connective tissue that allows tensional loading shearing mobility along interfaces; (2) system comprises four organs: superficial fascia, musculoskeletal (deep) visceral neural fascia; (3) these organs are further composed structures, some which eponymous; (4) all their structural components contain variable combinations arrangements classically tissues: epithelial, connective, muscle, neural; (5) overarching functions arise from contrasting biomechanical properties two basic types layers distributed system: one predominantly collagenous relatively stiff, other rich hyaluronic acid viscous, allowing for free flow fluid; (6) topographical organization different locations is related local variations function (e.g. unidirectional favor loading, interwoven structures shear mobility) thereby accounting both system's universal functional aspects site‐specific between them. A language will break down linguistic barriers facilitate cross‐disciplinary cooperation, enabling scientists practitioners diverse backgrounds contribute expertise seamlessly.

Language: Английский

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Impact of Vitamin D on Skin Aging, and Age-Related Dermatological Conditions

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 20, 2025

Human skin is a physical and biochemical barrier that protects the internal body from external environment. Throughout person’s life, undergoes both intrinsic extrinsic aging, leading to microscopic macroscopic changes in its morphology. In addition, repair processes slow with making older population more susceptible diseases. Intrinsic factors associated advanced age gradually degrade dermal collagen matrix, resulting fine wrinkles reduced elasticity; this accelerated post-menopausal women due estrogen deficiency. contrast, age, primarily caused by exposure ultraviolet (UV) radiation, lead coarse wrinkles, solar elastosis, hyperkeratosis, irregular pigmentation, cancers. UVB while contributing photo-aging, also induces cutaneous synthesis of vitamin D. Vitamin D, turn, oxidative stress, inflammation, DNA damage, thereby delaying chronological photo-aging. Moreover, research has demonstrated an association between lower D levels higher prevalence certain This review explores summarizes critical role aging age-related The data presented highlight importance maintaining adequacy throughout life.

Language: Английский

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Effects of Air Pollution on Cellular Senescence and Skin Aging

Cells, Journal Year: 2022, Volume and Issue: 11(14), P. 2220 - 2220

Published: July 17, 2022

The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution considered a harmful risk known promote aging inflammation of this tissue, leading the onset disorders appearance wrinkles pigmentation issues. Besides this, components can interact synergistically with light increase impact damage skin. However, little about modulation on cellular senescence in cells how contribute aging. In review, we are summarizing current state knowledge components, their involvement processes aging, well therapeutic cosmetic interventions proposed prevent or mitigate effects

Language: Английский

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β-Glucan extracts as high-value multifunctional ingredients for skin health: A review

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 322, P. 121329 - 121329

Published: Aug. 23, 2023

Language: Английский

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