Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(12), P. 3404 - 3421
Published: March 12, 2024
Abstract
Several
drugs
can
be
used
for
treating
inflammatory
skin
pathologies
like
dermatitis
and
psoriasis.
However,
the
management
of
chronic
long-term
cases,
topical
administration
is
preferred
over
oral
delivery
since
it
prevents
certain
issues
due
to
systemic
side
effects
from
occurring.
Cyclosporin
A
(CsA)
has
been
this
purpose;
however,
its
high
molecular
weight
(1202
Da)
restricts
diffusion
through
structure.
Here,
we
developed
a
nano-in-micro
device
combining
lipid
vesicles
(LVs)
dissolving
microneedle
array
patches
(DMAPs)
targeted
delivery.
CsA-LVs
allowed
effective
incorporation
CsA
in
hydrophilic
DMAP
matrix
despite
hydrophobicity
drug.
Polymeric
composed
poly
(vinyl
alcohol)
(5%
w/v),
pyrrolidine)
(15%
w/v)
CsA-LV
dispersion
(10%
v/v)
led
formation
CsA-LVs@DMAPs
with
adequate
mechanical
properties
penetrate
stratum
corneum
barrier.
The
safety
biocompatibility
were
ensured
an
vitro
viability
test
using
HaCaT
keratinocytes
L929
fibroblast
cell
lines.
Ex
vivo
permeability
studies
Franz-diffusion
setup
showed
drug
retention
Finally,
challenged
murine
model
delayed-type
hypersensitivity
corroborate
their
potential
ameliorate
conditions.
Different
findings
photon
emission
reduction
bioluminescence
study,
normalisation
histological
damage
decrease
cytokines
point
out
effectivity
treat
these
Overall,
our
study
demonstrates
that
downregulate
environment
which
paves
way
clinical
translation
use
as
alternative
corticosteroid-based
therapies.
Graphical
Drug Design Development and Therapy,
Journal Year:
2023,
Volume and Issue:
Volume 17, P. 341 - 361
Published: Feb. 1, 2023
Background:
Adaptogens
are
a
class
of
medicinal
plants
that
can
nonspecifically
enhance
human
resistance.
Most
the
plant
adaptogens
have
relevant
applications
in
dermatology,
but
there
still
few
studies
related
to
their
particular
action
and
co-operative
mechanisms
topical
skin
application.
Methods:
Plant
articles
reviews
published
between
1999
2022
were
obtained
from
Web
Science
Core
Collection
database.
Various
bibliographic
elements
collected,
including
annual
number
publications,
countries/regions,
keywords.
CiteSpace,
scientometric
software,
was
used
conduct
bibliometric
analyses.
Also,
patsnap
global
patent
database
analyze
situation
field
cosmetics
up
2021.
Results:
We
found
effects
on
diseases
mainly
involve
atopic
dermatitis,
acne,
allergic
contact
psoriasis,
eczema,
androgenetic
alopecia,
etc.
And
health
anti-aging
anti-photoaging,
anti-bacterial
anti-fungal,
anti-inflammatory,
whitening,
anti-hair
loss,
based
results
analysis,
it
is
focus
aging
retardation.
The
dermatological
Fabaceae
Lindl.,
Araliaceae
Juss.
Lamiaceae
Martinov.,
efficacy
phytochemical
components
terpenoids,
phenolic
compounds
flavonoids.
Conclusion:
repair
barrier
maintain
homeostasis
by
regulating
HPA-like
axis,
influencing
oxidative
stress
pathway
inhibit
inflammation,
extracellular
matrix
(ECM)
dynamic
equilibrium,
ultimately
achieving
treatment
maintenance
healthy
state.
Graphical
Abstract:
Keywords:
adaptogens,
ECMs,
homeostasis,
pharmacophylogeny
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: June 19, 2023
Naringenin
(NA)
is
a
natural
flavonoid
used
in
the
formulation
of
wide
range
pharmaceutical,
fragrance,
and
cosmetic
products.
In
this
research,
NA
was
extracted
from
Searsia
tripartita
using
an
environmentally
friendly,
high
efficiency
extraction
method:
ultrasound-assisted
with
deep
eutectic
solvents
(UAE-DES).Six
solvent
systems
were
tested.
Choline
chloride
as
hydrogen
bond
acceptor
(HBA),
formic
acid,
ethylene
glycol,
lactic
urea,
glycerol,
citric
acid
donors
(HBD).Based
on
results
single-factor
experiments,
response
surface
methodology
Box-Behnken
design
applied
to
determine
optimal
conditions
for
UAE-DES.
According
results,
parameters
follows:
DES-1
consisted
choline
(HBA)
(HBD)
mole
ratio
2:1,
time
10
min,
temperature
50°C,
ultrasonic
amplitude
75
W,
solid-liquid
1/60
g/mL.
Extracted
shown
inhibit
activity
different
enzymes
vitro,
including
α-amylase,
acetylcholinesterase,
butyrylcholinesterase,
tyrosinase,
elastase,
collagenase,
hyaluronidase.Thus,
UAE-DES
technique
produced
high-efficiency
while
retaining
bioactivity,
implying
broad
application
potential,
making
it
worthy
consideration
high-throughput
green
method.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Jan. 31, 2023
Abstract
Skin
homeostasis
is
a
complex
regulated
process
relying
on
the
crosstalk
of
keratinocytes,
fibroblasts
and
immune
cells.
Imbalances
T-cell
subsets
cytokine
environment
can
lead
to
inflammatory
skin
diseases
such
as
psoriasis
(Ps)
atopic
dermatitis
(AD).
Modern
tissue
engineering
provides
several
in
vitro
models
mimicking
Ps
AD
phenotypes.
However,
these
are
either
limited
their
pathological
features,
life
span,
sample
availability,
reproducibility,
controlled
handling
or
simplicity.
Some
further
lack
intensive
characterization
they
solely
focus
differentiation
proliferation
aspects.
This
study
introduces
self-assembly
model
which
T-cell-signalling
was
simulated
by
subcutaneous
Th1
Th2
stimulation.
The
self-established
dermal
fibroblast-derived
matrices
were
hypothesized
be
beneficial
for
proximal
signalling
epidermal
keratinocytes.
Comprehensive
histological
mRNA
analyses
diseased
showed
weakened
barrier,
distinct
defects,
reduced
cellular
adhesion,
inflammation
parakeratosis
formation.
A
keratin
shift
declining
physiological
cytokeratin-10
(CK10)
towards
increasing
CK16
observed
upon
Antimicrobial
peptides
(AMPs)
upregulated
downregulated
models.
biomarker
genes
CA2
,
NELL2
CCL26
induced
AD.
While
samples
featured
basal
hyperproliferation,
cells
displayed
apoptotic
signs.
In
accordance,
well-controllable
three-dimensional
exhibited
AD-like
phenotypes
with
high
potential
disease
research
therapeutic
drug
testing.
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(12), P. 3404 - 3421
Published: March 12, 2024
Abstract
Several
drugs
can
be
used
for
treating
inflammatory
skin
pathologies
like
dermatitis
and
psoriasis.
However,
the
management
of
chronic
long-term
cases,
topical
administration
is
preferred
over
oral
delivery
since
it
prevents
certain
issues
due
to
systemic
side
effects
from
occurring.
Cyclosporin
A
(CsA)
has
been
this
purpose;
however,
its
high
molecular
weight
(1202
Da)
restricts
diffusion
through
structure.
Here,
we
developed
a
nano-in-micro
device
combining
lipid
vesicles
(LVs)
dissolving
microneedle
array
patches
(DMAPs)
targeted
delivery.
CsA-LVs
allowed
effective
incorporation
CsA
in
hydrophilic
DMAP
matrix
despite
hydrophobicity
drug.
Polymeric
composed
poly
(vinyl
alcohol)
(5%
w/v),
pyrrolidine)
(15%
w/v)
CsA-LV
dispersion
(10%
v/v)
led
formation
CsA-LVs@DMAPs
with
adequate
mechanical
properties
penetrate
stratum
corneum
barrier.
The
safety
biocompatibility
were
ensured
an
vitro
viability
test
using
HaCaT
keratinocytes
L929
fibroblast
cell
lines.
Ex
vivo
permeability
studies
Franz-diffusion
setup
showed
drug
retention
Finally,
challenged
murine
model
delayed-type
hypersensitivity
corroborate
their
potential
ameliorate
conditions.
Different
findings
photon
emission
reduction
bioluminescence
study,
normalisation
histological
damage
decrease
cytokines
point
out
effectivity
treat
these
Overall,
our
study
demonstrates
that
downregulate
environment
which
paves
way
clinical
translation
use
as
alternative
corticosteroid-based
therapies.
Graphical
