Advancing cell therapy for neurodegenerative diseases

Cell stem cell, Journal Year: 2023, Volume and Issue: 30(5), P. 512 - 529

Published: April 20, 2023

Language: Английский

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Clinical trials for progressive multiple sclerosis: progress, new lessons learned, and remaining challenges

The Lancet Neurology, Journal Year: 2024, Volume and Issue: 23(3), P. 277 - 301

Published: Feb. 15, 2024

Language: Английский

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Alterations of Oligodendrocyte and Myelin Energy Metabolism in Multiple Sclerosis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12912 - 12912

Published: Aug. 18, 2023

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system (CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play vital role in maintaining integrity myelin, protective sheath around nerve fibres essential for efficient signal transmission. However, MS, oligodendrocytes become dysfunctional, leading to myelin damage axonal degeneration. Emerging evidence suggests that metabolic changes, including mitochondrial dysfunction alterations glucose lipid metabolism, contribute significantly pathogenesis MS. Mitochondrial observed both immune cells within CNS MS patients. Impaired function leads energy deficits, affecting crucial processes such as impulse transmission transport, ultimately contributing Moreover, linked generation reactive oxygen species (ROS), exacerbating inflammation. Altered metabolism affects supply required oligodendrocyte synthesis. Dysregulated results changes composition its stability integrity. Importantly, low levels polyunsaturated fatty acids are associated with upregulated enhanced catabolism. Understanding intricate relationship between these mechanisms developing targeted therapies preserve promote neurological recovery individuals Addressing aspects may offer new insights into potential therapeutic strategies halt progression improve quality life

Language: Английский

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Advances in clinical translation of stem cell-based therapy in neurological diseases

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Stem cell-based therapies have raised considerable interest to develop regenerative treatment for neurological disorders with high disability. In this review, we focus on recent preclinical and clinical evidence of stem cell therapy in the degenerative diseases discuss different types, delivery routes biodistribution therapy. addition, advances mechanistic insights therapy, including functional replacement by exogenous cells, immunomodulation paracrine effects are also demonstrated. Finally, highlight adjunction approaches that has been implemented augment their reparative function, survival migration target specific tissue, preconditioning, genetical engineering, co-transplantation combined

Language: Английский

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Soluble factors influencing the neural stem cell niche in brain physiology, inflammation, and aging

Experimental Neurology, Journal Year: 2022, Volume and Issue: 355, P. 114124 - 114124

Published: May 26, 2022

Language: Английский

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Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 76, P. 30 - 47

Published: Feb. 2, 2024

Language: Английский

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FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(6), P. 1497 - 1511

Published: March 16, 2023

Background With millions of victims worldwide, multiple sclerosis is the second most common cause disability among young adults. Although formidable advancements have been made in understanding disease, neurodegeneration associated with only partially counteracted by current treatments, and effective therapy for progressive remains an unmet need. Therefore, new approaches are required to delay demyelination resulting restore neural function promoting remyelination neuronal repair. Aims The article reviews latest literature this field. Materials methods fibroblast growth factor (FGF) signaling pathway a promising target sclerosis. Discussion FGF signal transduction contributes establishing oligodendrocyte lineage, stem cell proliferation differentiation, myelination central nervous system. Furthermore, implicated control neuroinflammation. In recent years, interventions targeting FGF, its receptor (FGFR) shown ameliorate autoimmune encephalomyelitis symptoms animal models moderately. Conclusion Here, we summarize findings investigate role FGF/FGFR onset progression, discuss potential therapeutic advances, offer fresh insights into managing

Language: Английский

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Stem Cells in Clinical Trials on Neurological Disorders: Trends in Stem Cells Origins, Indications, and Status of the Clinical Trials

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11453 - 11453

Published: Sept. 28, 2022

Neurological diseases can significantly reduce the quality and duration of life. Stem cells provide a promising solution, not only due to their regenerative features but also for variety other functions, including reducing inflammation promoting angiogenesis. Although hematopoietic have been approved by FDA so far, number trials continues expand. We analyzed 492 clinical illustrate trends in stem origins, indications, phase status trials. The most common neurological disorders treated with were injuries brain, spinal cord, peripheral nerves (14%), stroke (13%), multiple sclerosis (12%), brain tumors (11%). Mesenchymal dominated (83%) although choice was highly dependent on disorder. Of trials, two reached 4, all being phases 1 or 2, transitioning between them (83%). Based comparison obtained results similar works further analysis literature, we discuss some challenges future directions cell therapies treatment diseases.

Language: Английский

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Stem cell therapies: a new era in the treatment of multiple sclerosis

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Multiple Sclerosis (MS) is an immune-mediated condition that persistently harms the central nervous system. While existing treatments can slow its course, a cure remains elusive. Stem cell therapy has gained attention as promising approach, offering new perspectives with regenerative and immunomodulatory properties. This article reviews application of stem cells in MS, encompassing various types, therapeutic potential mechanisms, preclinical explorations, clinical research advancements, safety profiles applications, well limitations challenges, aiming to provide insights into treatment for MS.

Language: Английский

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Regenerating Locus Coeruleus‐Norepinephrine (LC‐NE) Function: A Novel Approach for Neurodegenerative Diseases

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT Pathological changes in the locus coeruleus‐norepinephrine (LC‐NE) neurons, major source of norepinephrine (NE, also known as noradrenaline) brain, are evident during early stages neurodegenerative diseases (ND). Research on both human and animal models have highlighted therapeutic potential targeting LC‐NE system to mitigate progression ND alleviate associated psychiatric symptoms. However, widespread degeneration presents a significant challenge for direct intervention ND. Recent advances regenerative cell therapy offer promising new strategies treatment. The regeneration from pluripotent stem cells (PSCs) could significantly broaden scope LC‐NE‐based therapies In this review, we delve into fundamental background physiological functions LC‐NE. Additionally, systematically examine evidence role neuropathology over recent years. Notably, focus significance PSCs‐derived its impact therapy. A deeper understanding further investigation function pave way practical effective treatments

Language: Английский

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