Mesenchymal Stem Cell Membrane‐Derived Composite System for Enhancing the Tumor Treatment Efficacy of Metal–Organic Framework Nanoparticles DOI Creative Commons
Ying Tong, Gao Meng, Ying‐Li Luo

et al.

IET Nanobiotechnology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Mesenchymal stem cell (MSC) membrane‐coated metal–organic frameworks (MOFs) represent an innovative approach to enhance the uptake and therapeutic efficacy of copper‐based MOFs (Cu‐MOFs) in tumor cells. By leveraging natural homing abilities biocompatibility MSC membranes, Cu‐MOFs can be effectively targeted sites, promoting increased cellular uptake. This coating not only facilitates superior internalization by cancer cells but also augments outcomes due enhanced delivery copper ions. In vitro studies demonstrate that (MSC‐Cu‐MOFs) significantly improve cytotoxic effects on compared uncoated Cu‐MOFs. novel strategy presents a promising avenue for advancing precision effectiveness treatment modalities, showcasing potential clinical applications oncology.

Language: Английский

Oleanolic acid alleviating ischemia-reperfusion injury in rat severe steatotic liver via KEAP1/NRF2/ARE DOI Creative Commons

PI Yi-hua,

Huaiwen Zuo,

Yuxin Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112617 - 112617

Published: July 6, 2024

Severe steatosis in donor livers is contraindicated for transplantation due to the high risk of ischemia-reperfusion injury (IRI). Although Ho-1 gene-modified bone marrow mesenchymal stem cells (HO-1/BMMSCs) can mitigate IRI, role gut microbiota and metabolites this protection remains unclear. This study aimed explore how contribute HO-1/BMMSCs-mediated against IRI severe steatotic livers. Using rat models cellular (IAR20 THLE-2 cells) liver revealed that led significant intestinal damage, heightened immune responses, impaired function, altered metabolite profiles rats with steatosis, which were partially reversed by HO-1/BMMSCs transplantation. Integrated microbiome metabolome analyses identified microbial oleanolic acid as a potential protective agent IRI. Experimental validation showed administration alone alleviated inhibited ferroptosis both models. Network pharmacology molecular docking implicated KEAP1/NRF2 pathway target acid. Indeed, OA experimentally upregulated NRF2 activity, underlies its inhibition The protects promoting expression thereby inhibiting ferroptosis.

Language: Английский

Citations

4
The role of mesenchymal stem cells in cancer and prospects for their use in cancer therapeutics DOI Creative Commons
Jian Tang, Yu Chen,

Chunhua Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 28, 2024

Abstract Mesenchymal stem cells (MSCs) are recruited by malignant tumor to the microenvironment (TME) and play a crucial role in initiation progression of tumors. This encompasses immune evasion, promotion angiogenesis, stimulation cancer cell proliferation, correlation with cells, multilineage differentiation within TME, development treatment resistance. Simultaneously, extensive research is exploring homing effect MSCs MSC‐derived extracellular vesicles (MSCs‐EVs) tumors, aiming design them as carriers for antitumor substances. These substances targeted deliver drugs enhance drug efficacy while reducing toxicity. paper provides review supportive associated molecular mechanisms. Additionally, we summarize latest therapeutic strategies involving engineered MSCs‐EVs treatment, including their utilization gene agents, chemotherapeutics, oncolytic viruses. We also discuss distribution clearance upon entry into body elucidate potential therapies based on along challenges they face.

Language: Английский

Citations

4
Mesenchymal Stem Cell–Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease DOI Creative Commons

Carl Randall Harrell,

Valentin Djonov, Ana Volarevic

et al.

Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Severe dry eye disease (DED) is an inflammatory condition characterized by a lack of sufficient moisture or lubrication on the surface eye, significantly impacting quality life and visual function. Since detrimental immune response crucially responsible for development aggravation DED, therapeutic agents which modulate phenotype function eye-infiltrated cells could be used treatment severe DED. Due to their potent immunomodulatory properties, mesenchymal stem (MSCs) represent potentially new remedies diseases. The majority MSC-sourced bioactive factors are contained within MSC-derived exosomes (MSC-Exos), nano-sized extracellular vesicles which, due nanosize dimension lipid envelope, easily pass all biological barriers in body deliver cargo directly into target cells. MSC-Exos contain variety proteins (growth factors, immunoregulatory molecules, cytokines, chemokines) lipids, microRNAs (miRNAs) affect viability, proliferation, phenotype, Accordingly, may progression diseases, including Therefore, this review article, we summarized current knowledge regarding molecular cellular mechanisms were trophic, anti-inflammatory, immunoregulatory, regenerative properties For purpose, extensive literature was carried out February 2024 across several databases (Medline, Embase, Google Scholar), from 2000 present. Eligible studies delineated MSC-Exos-based modulation cell-driven inflammation findings analyzed review. Results obtained these demonstrated beneficial effects paving way future clinical use ophthalmology. Trial Registration: ClinicalTrials.gov identifier: NCT04213248, NCT06475027, NCT06543667, NCT05738629.

Language: Английский

Citations

0
Immunomodulatory effects of mesenchymal stem cell therapy in chronic kidney disease: a literature review DOI Creative Commons

Jipeng Li,

Mengting Wu,

Lijie He

et al.

BMC Nephrology, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 3, 2025

Chronic kidney disease (CKD) has been a growing public medical concern in recent years which calls for effective interventions. Mesenchymal stem cells (MSCs) have garnered increased interest past decades due to their potential repair and regenerate damaged tissues. Many clinical trials highlighted the safety effectiveness of with this novel cell therapy. MSC infusion can improve renal function indices such as glomerular filtration rate, urine protein, serum creatinine, blood urea nitrogen, while inhibiting immune response by increasing regulatory T cells. The therapeutic mechanisms may be primarily attributed combined immunomodulation, anti-inflammation, anti-fibrosis, promoting angiogenesis, anti-oxidation, anti-apoptosis, or tissue healing produced secretsome. However, CKD is broad concept many pathological etiologies including diabetes, hypertension, heart disease, immunological damage, family history failure, so on. Furthermore, efficacy MSCs influenced different sources, injection methods, medication dosage, homing proportion. As result, it timely essential access advancements application on CKD.

Language: Английский

Citations

0
Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system DOI

Sumit Mallick,

Vanya Kadla Narayana, Akhila Balakrishna

et al.

The International Journal of Biochemistry & Cell Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106773 - 106773

Published: April 1, 2025

Language: Английский

Citations

0
Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy DOI Creative Commons

Mei-Lin Yang,

Che‐Yuan Hu,

Ya-Che Lee

et al.

Stem Cells Translational Medicine, Journal Year: 2024, Volume and Issue: 13(8), P. 738 - 749

Published: June 12, 2024

Abstract Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can be used cellular vehicles delivering oncolytic sites. Since telomerase activity is found in ~90% human carcinomas, but undetected normal adult cells, reverse transcriptase gene (TERT) promoter exploited regulating replication adenoviruses. Here, we evaluated antitumor effects syngeneic murine MSCs loaded with luciferase-expressing, telomerase-dependent adenovirus Ad.GS2 (MSC-Ad.GS2) alone on MBT-2 bladder tumors. supported low degree replication, which could augmented by coculture or tumor-conditioned medium (TCM), suggesting that viral increased when MSC-Ad.GS2 migrates TCM enhanced Ad.GS2-infected MSCs. SDF-1 cell homing factor. Our results suggest SDF-1/STAT3/TERT signaling axis response microenvironment may contribute carried Notably, demonstrate potent efficacy systemically delivered pleural disseminated experimental metastasis models using intrapleural tail vein injection respectively. Treatment significantly reduced growth prolonged survival mice bearing expressed broad spectrum cancers, this strategy broadly applicable.

Language: Английский

Citations

2
Mesenchymal Stem Cell Membrane‐Derived Composite System for Enhancing the Tumor Treatment Efficacy of Metal–Organic Framework Nanoparticles DOI Creative Commons
Ying Tong, Gao Meng, Ying‐Li Luo

et al.

IET Nanobiotechnology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Mesenchymal stem cell (MSC) membrane‐coated metal–organic frameworks (MOFs) represent an innovative approach to enhance the uptake and therapeutic efficacy of copper‐based MOFs (Cu‐MOFs) in tumor cells. By leveraging natural homing abilities biocompatibility MSC membranes, Cu‐MOFs can be effectively targeted sites, promoting increased cellular uptake. This coating not only facilitates superior internalization by cancer cells but also augments outcomes due enhanced delivery copper ions. In vitro studies demonstrate that (MSC‐Cu‐MOFs) significantly improve cytotoxic effects on compared uncoated Cu‐MOFs. novel strategy presents a promising avenue for advancing precision effectiveness treatment modalities, showcasing potential clinical applications oncology.

Language: Английский

Citations

0