Magnetic iron oxide nanoparticles for brain imaging and drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114822 - 114822

Published: April 21, 2023

Central nervous system (CNS) disorders affect as many 1.5 billion people globally. The limited delivery of most imaging and therapeutic agents into the brain is a major challenge for treatment CNS disorders. With advent nanotechnologies, controlled drugs with nanoparticles holds great promise in overcoming blood-brain barrier (BBB) improving efficacy. In recent years, magnetic iron oxide (MIONPs) have stood out promising theranostic nanoplatform drug they possess unique physical properties biodegradable characteristics. this review, we summarize advances MIONP-based platforms diseases. We firstly introduce methods synthesis surface functionalization MIONPs emphasis on inclusion biocompatible polymers that allow addition tailored physicochemical properties. then discuss vivo applications using MIONPs. Finally, present perspective remaining challenges possible future directions systems.

Language: Английский

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Use of Real‐World Evidence to Drive Drug Development Strategy and Inform Clinical Trial Design

Clinical Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 111(1), P. 77 - 89

Published: Nov. 28, 2021

Interest in real‐world data (RWD) and evidence (RWE) to expedite enrich the development of new biopharmaceutical products has proliferated recent years, spurred by 21st Century Cures Act United States similar policy efforts other countries, willingness regulators consider RWE their decisions, demands from third‐party payers, growing concerns about limitations traditional clinical trials. Although much literature on focused potential regulatory uses (e.g., product approvals oncology or rare diseases based single‐arm trials with external control arms), this article reviews how companies can leverage inform internal decisions made throughout process. Specifically, will review use RWD guide pipeline portfolio strategy; novel sources development, advanced analytics harness “big” RWD, considerations when using decisions. Topics discussed include molecular, clinicogenomic, medical imaging, radiomic, patient‐derived xenograft augment RWE, trial eligibility criteria, population predicted response, select endpoints, estimate sample size, understand disease progression, enhance diversity participants, tokenization analytical techniques artificial intelligence as well importance quality methodological transparency RWE.

Language: Английский

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Nanoparticles in ocular applications and their potential toxicity

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 9

Published: July 15, 2022

Nanotechnology has been developed rapidly in recent decades and widely applied ocular disease therapy. Nano-drug delivery systems overcome the bottlenecks of current ophthalmic drug are characterized with strong biocompatibility, stability, efficiency, sustainability, controllability, few side effects. Nanoparticles have identified as a promising generally safe drug-delivery system based on toxicity assessment animals. Previous studies found that common nanoparticles can be toxic to cornea, conjunctiva, retina under certain conditions. Because species differences between humans animals, advanced vitro cell culture techniques, such human organoids, mimic organism extent, bringing nanoparticle new stage. This review summarizes application potential toxicity, well some challenges future opportunities nanotoxicological evaluation.

Language: Английский

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Experimental and Computational Nanotoxicology—Complementary Approaches for Nanomaterial Hazard Assessment

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(8), P. 1346 - 1346

Published: April 14, 2022

The growing development and applications of nanomaterials lead to an increasing release these materials in the environment. adverse effects they may elicit on ecosystems or human health are not always fully characterized. Such potential toxicity must be carefully assessed with underlying mechanisms elucidated. To that purpose, different approaches can used. First, experimental toxicology consisting conducting vitro vivo experiments (including clinical studies) used evaluate nanomaterial hazard. It rely variable models (more less complex), allowing investigation biological endpoints. respective advantages limitations discussed as well some issues associated nanotoxicology. Perspectives future developments field also proposed. Second, computational nanotoxicology, i.e., silico approaches, predict toxicity. In this context, we describe general principles, advantages, especially quantitative structure–activity relationship (QSAR) grouping/read-across approaches. aim review is provide overview based examples highlight their complementarity.

Language: Английский

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Heterotypic tumor spheroids: a platform for nanomedicine evaluation

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 2, 2023

Abstract Nanomedicine has emerged as a promising therapeutic approach, but its translation to the clinic been hindered by lack of cellular models anticipate how tumor cells will respond therapy. Three-dimensional (3D) cell culture are thought more accurately recapitulate key features primary tumors than two-dimensional (2D) cultures. Heterotypic 3D spheroids, composed multiple types, have become popular homotypic which consist single type, superior model for mimicking in vivo heterogeneity and physiology. The stromal interactions demonstrated heterotypic spheroids can affect various aspects, including response therapy, cancer progression, nanomedicine penetration, drug resistance. Accordingly, design effective anticancer nanomedicinal therapeutics, not only also (e.g., fibroblasts immune cells) should be considered create physiologically relevant microenvironment. This review aims demonstrate current knowledge research, illustrate advances utilizing these novel versatile platform vitro evaluation nanomedicine-based therapeutics discuss challenges, guidelines, future directions this field. Graphical

Language: Английский

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Novel Organoid Culture System for Improved Safety Assessment of Nanomaterials

Nano Letters, Journal Year: 2024, Volume and Issue: 24(3), P. 805 - 813

Published: Jan. 12, 2024

Over the past few decades, increased application of nanomaterials has raised questions regarding their safety and possible toxic effects. Organoids have been suggested as promising tools, offering efficient assays for nanomaterial-induced toxicity evaluation. However, organoid systems some limitations, such size heterogeneity poor penetration nanoparticles because extracellular matrix, which is necessary culture. Here, we developed a novel system improved assessment by establishing 3D floating paradigm. In addition to overcoming limitations two-dimensional including lack

Language: Английский

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Advances in medical devices using nanomaterials and nanotechnology: Innovation and regulatory science

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 353 - 369

Published: Feb. 20, 2025

Language: Английский

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Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 396(11), P. 2861 - 2880

Published: June 2, 2023

Language: Английский

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Assessing thein vitrotoxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models

Journal of Toxicology and Environmental Health Part B, Journal Year: 2023, Volume and Issue: 26(2), P. 67 - 96

Published: Jan. 24, 2023

Several studies have been conducted to address the potential adverse health risks attributed exposure nanoscale materials. While in vivo are fundamental for identifying relationship between dose and occurrence of effects, vitro model systems provide important information regarding mechanism(s) action at molecular level. With a special focus on inhaled (nano)particulate material toxicity assessment, this review provides an overview available human respiratory models testing, advantages, limitations, existing investigations using different complexity. A brief system, pathway fate (nano)particles is also presented.

Language: Английский

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Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108744 - 108744

Published: May 11, 2024

Microplastic (MP) pollution has become a global environmental issue, and increasing concern been raised about its impact on human health. Current studies the toxic effects mechanisms of MPs have mostly conducted in animal models or vitro cell cultures, which limitations regarding inter-species differences stimulation cellular functions. Organoid technology derived from pluripotent adult stem cells broader prospects for predicting potential health risks to humans. Herein, we reviewed current application advancements opportunities different organoids, including brain, retinal, intestinal, liver, lung assess MPs. techniques accurately simulate complex processes reflect phenotypes related diseases caused by such as liver fibrosis, neurodegeneration, impaired intestinal barrier cardiac hypertrophy. Future perspectives were also proposed technological innovation risk assessment using extending lifespan organoids chronic toxicity MPs, reconstructing multi-organ interactions explore their studying microbiome-gut-brain axis effect

Language: Английский

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