The SLIT/ROBO Pathway in Liver Fibrosis and Cancer

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 785 - 785

Published: May 1, 2023

Liver fibrosis is a common outcome of most chronic liver insults/injuries that can develop into an irreversible process cirrhosis and, eventually, cancer. In recent years, there has been significant progress in basic and clinical research on cancer, leading to the identification various signaling pathways involved tumorigenesis disease progression. Slit glycoprotein (SLIT)1, SLIT2, SLIT3 are secreted members protein family accelerate positional interactions between cells their environment during development. These proteins signal through Roundabout receptor (ROBO) receptors (ROBO1, ROBO2, ROBO3, ROBO4) achieve cellular effects. The SLIT ROBO pathway acts as neural targeting factor regulating axon guidance, neuronal migration, axonal remnants nervous system. Recent findings suggest tumor differ SLIT/ROBO levels show varying degrees expression patterns angiogenesis, cell invasion, metastasis, infiltration. Emerging roles axon-guidance molecules have discovered cancer Herein, we examined normal adult livers two types cancers: hepatocellular carcinoma cholangiocarcinoma. This review also summarizes potential therapeutics this for anti-fibrosis anti-cancer drug

Language: Английский

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Structural and Temporal Dynamics of Mesenchymal Stem Cells in Liver Diseases From 2001 to 2021: A Bibliometric Analysis

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 19, 2022

Background Mesenchymal stem cells (MSCs) have important research value and broad application prospects in liver diseases. This study aims to comprehensively review the cooperation influence of countries, institutions, authors, journals field MSCs diseases from perspective bibliometrics, evaluate clustering evolution knowledge structure, discover hot trends emerging topics. Methods The articles reviews related were retrieved Web Science Core Collection using Topic Search. A bibliometric was performed CiteSpace VOSviewer. Results total 3404 included over period 2001-2021. number regarding showed an increasing trend. These publications mainly come 3251 institutions 113 countries led by China USA. Li L published most papers among publications, while Pittenger MF had co-citations. Analysis productive shows that are specialized medical research, experimental medicine cell biology, & tissue engineering. macroscopical sketch micro-representation whole realized through co-citation analysis. Liver scaffold, MSC therapy, extracellular vesicle, others current developing areas study. keywords “machine perfusion”, “liver transplantation”, “microRNAs” also may be focus new future research. Conclusions In this study, bibliometrics visual methods used comprehensively. paper will help scholars better understand dynamic point out direction for

Language: Английский

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Targeting HSP47 and HSP70: promising therapeutic approaches in liver fibrosis management

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 26, 2022

Abstract Liver fibrosis is a liver disease in which there an excessive buildup of extracellular matrix proteins, including collagen. By regulating cytokine production and the inflammatory response, heat shock proteins (HSPs) contribute significantly to wider spectrum fibrotic illnesses, such as lung, liver, idiopathic pulmonary by aiding folding assembly freshly synthesized HSPs serve chaperones. HSP70 one key avoiding protein aggregation induces its action sending unfolded and/or misfolded ubiquitin–proteasome degradation pathway antagonizing influence on epithelial-mesenchymal transition. HSP47, other hand, crucial for boosting collagen synthesis, deposition, fostering emergence disorders. The current review aims provide light how HSP47 affect hepatic fibrogenesis. Additionally, our looks into new therapeutic approaches that target could potentially be used drug candidates treat fibrosis, especially cases comorbidities.

Language: Английский

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Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 10, 2023

Liver fibrosis, which is characterized by the excessive deposition of extracellular matrix (ECM) materials (primarily fibrillar collagen-I), an abnormal repair reaction and pathological outcome chronic liver diseases caused alcohol abuse, non-alcoholic fatty disease, hepatitis B C virus infections. fibrosis often progresses to cirrhosis hepatocellular carcinoma. Ferroptosis, lipid peroxidation, a form iron-dependent non-apoptotic cell death, recent studies have reported that ferroptosis contribute development fibrosis. Moreover, several agents demonstrated therapeutic effects in experimental models inducing hepatic stellate (HSCs) ferroptosis. This review delineates specific mechanism contributes Specifically, we focused on different types can induce HSCs summarize their pharmacological effectiveness for treatment. We suggest may be potential useful target novel therapies preventing treating

Language: Английский

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DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing Wnt/β-catenin signaling

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 24, 2024

Liver fibrosis, as a consequence of chronic liver disease, involves the activation hepatic stellate cell (HSC) caused by various injuries. Emerging evidence suggests that HSC during an inflammatory state can lead to abnormal accumulation extracellular matrix (ECM). Investigating novel strategies inhibit and proliferation holds significant importance for treatment fibrosis. As member doublecortin domain-containing family, domain containing 2 (DCDC2) mutations neonatal sclerosing cholangitis, but its involvement in fibrosis remains unclear. Therefore, this study aims elucidate role DCDC2 Our findings revealed reduction expression both human fibrotic tissues carbon tetrachloride (CCl

Language: Английский

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