Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 815 - 815
Published: July 7, 2024
Colorectal
cancer
(CRC)
is
a
leading
cause
of
deaths
worldwide.
Despite
significant
advances
in
medical
treatment,
chemotherapy
as
monotherapy
can
lead
to
substantial
side
effects
and
chemoresistance.
This
underscores
the
need
for
therapeutic
approaches
that
are
not
only
pharmacologically
safe
but
also
modulate
multiple
potent
signaling
pathways
sensitize
cells
overcome
resistance
standard
drugs.
In
recent
years,
scientists
have
been
searching
natural
compounds
be
used
chemosensitizers
addition
conventional
medications
synergistic
treatment
CRC.
Polyphenols
represent
diverse
group
target
induce
anti-cancer
effects.
Additionally,
polyphenols
shown
work
synergistically
with
chemotherapeutics
other
cells.
review
aims
provide
comprehensive
insight
into
mechanisms
selected
CRC
Further
research
clinical
trials
warranted
fully
harness
combined
or
improving
outcomes.
ABSTRACT
Breast
cancer
is
the
most
common
type
of
malignancy
among
women
worldwide.
Significant
achievements
have
been
made
in
diagnostic
tools
and
treatments
past
decade;
however,
complexity
heterogeneity
certain
breast
subtypes
often
lead
to
drug
resistance
metastatic
progression.
Owing
their
low
toxicity
high
variety,
natural
products
derivatives
are
becoming
increasingly
valuable
sources
for
small‐molecule
anticancer
drugs.
Polyphenols
more
widely
known
role
prevention
as
adjuvants
conventional
treatment
strategies.
Therefore,
this
review
focuses
on
antitumor
effects
curcumin,
resveratrol,
polydatin
cancer.
According
main
databases,
only
vitro
preclinical
studies
with
solid
scientific
backgrounds
reports
protective
were
included.
Curcumin,
antioxidant,
anti‐inflammatory,
effects;
indeed,
they
improve
efficacy;
reduce
chemoresistance,
angiogenesis,
tumor
growth;
induce
apoptosis,
autophagy,
cell
cycle
arrest
through
multiple
molecular
pathways,
including
suppression
epithelial–mesenchymal
transition
(EMT),
NF‐κB,
PI3K/Akt/mTOR,
c‐Jun
N‐terminal
kinase
(JNK),
MAPK,
ERK1/2,
STAT
signaling
pathways;
inhibition
cyclins
matrix
metalloproteinase
(MMP)‐2
MMP‐9;
activation
p53
microtubule‐associated
protein
light
chain
3
(LC3).
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 23, 2024
Introduction:
Based
on
extensive
data
from
oncology
research,
the
use
of
phytochemicals
or
plant-based
nutraceuticals
is
considered
an
innovative
tool
for
cancer
management.
This
research
aimed
to
analyze
oncostatic
properties
Salvia
officinalis
L.
[Lamiaceae;
Salviae
herba]
using
animal
and
in
vitro
models
breast
carcinoma
(BC).
Methods:
The
effects
dietary
administered
S.
two
concentrations
(0.1%/SAL
0.1/and
1%/SAL
1/)
were
assessed
both
syngeneic
4T1
mouse
chemically
induced
rat
BC.
histopathological
molecular
evaluations
rodent
specimens
performed
after
autopsy.
Besides,
numerous
analyses
human
cell
lines
performed.
Results
Conclusion:
dominant
metabolites
found
propylene
glycol
extract
(SPGE)
representatives
phenolics,
specifically
rosmarinic,
protocatechuic,
salicylic
acids.
Furthermore,
occurrence
triterpenoids
ursolic
oleanolic
acid
was
proved
SPGE.
In
a
model,
non-significant
tumor
volume
decrease
treatment
associated
with
significant
reduction
mitotic
activity
index
tumors
by
37.5%
(SAL
0.1)
31.5%
1)
vs.
controls
(set
as
blank
group
not
applied
salvia
diet).
addition,
at
higher
doses
significantly
decreased
necrosis/whole
area
ratio
46%
when
compared
control
samples.
chemoprevention
study,
dose
lengthened
latency
8.5
days
improved
high/low-grade
carcinomas
doses.
Analyses
mechanisms
anticancer
activities
S
.
included
well-validated
prognostic,
predictive,
diagnostic
biomarkers
that
are
practice
preclinical
investigation.
Our
assessment
vivo
revealed
changes
comparison
treated
untreated
cells.
this
regard,
we
overexpression
caspase-3,
increased
Bax/Bcl-2
ratio,
MDA,
ALDH1,
EpCam
expression.
reduced
TGF-β
serum
levels
rats
(decrease
IL-6
TNF-α
borderline
significance).
Evaluation
epigenetic
modifications
decline
lysine
methylations
H3K4m3
increase
acetylation
H4K16ac
groups.
relative
oncogenic
miR21
tumor-suppressive
miR145
(miR210,
miR22,
miR34a,
miR155
altered).
methylation
ATM
PTEN
promoters
(
PITX2,
RASSF1
,
TIMP3
Analyzing
plasma
metabolomics
profile
tumor-bearing
rats,
ketoacids
derived
BCAAs
treatment.
anti-cancer
SPGE
MCF‐7
MDA-MB-231
(cytotoxicity,
caspase‐3/-7,
Bcl‐2,
Annexin
V/PI,
cycle,
BrdU,
mitochondrial
membrane
potential).
study
demonstrates
chemopreventive
haulm
BC
models.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(8), P. 1718 - 1718
Published: April 10, 2024
Polyphenols,
the
main
antioxidants
of
diet,
have
shown
anti-inflammatory,
antioxidant
and
anticarcinogenic
activities.
Here,
we
compared
effects
four
polyphenolic
compounds
on
ROS
production
levels
matrix
metalloproteinase
(MMP)-2
-9,
which
represent
important
pathogenetic
factors
breast
cancer.
THP-1
differentiated
macrophages
were
activated
by
LPS
simultaneously
treated
with
different
doses
a
green
tea
extract
(GTE),
resveratrol
(RSV),
curcumin
(CRC)
an
olive
fruit
(oliplus).
By
using
2,2-Diphenyl-1-picrylhydrazyl
(DPPH)
radical
scavenging
assay,
found
that
all
tested
showed
activity
in
vitro.
In
addition,
GTE,
RSV
CRC
able
to
counteract
induced
H
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 31
Published: March 21, 2025
This
review
examines
recent
advancements
in
nanoparticle-based
delivery
systems
for
phytochemicals,
focusing
on
their
role
overcoming
multidrug
resistance,
improving
therapeutic
efficacy,
and
facilitating
clinical
translation.
highlights
advances
nanoparticle-enabled
phytochemical
to
enhance
bioavailability,
improve
outcomes,
enable
targeted
applications.
By
comparing
various
nanoparticle
systems,
formulation
methods,
efficacy
data,
it
identifies
gaps
current
research
guides
the
development
of
more
effective,
next-generation
phytochemical-loaded
nanocarriers.
A
systematic
literature
published
between
2000
2024
was
conducted
using
PubMed,
Scopus,
Web
Science.
Articles
cancer
therapy
were
included.
Compounds
such
as
curcumin,
resveratrol,
quercetin,
epigallocatechin
gallate
demonstrate
enhanced
anti-cancer
when
encapsulated
nanoparticles,
leading
improved
increased
tumor
cell
targeting,
reduced
toxicity.
Clinical
trials
indicate
regression
fewer
adverse
effects.
Emerging
approaches-such
nanogels,
hybrid
combination
therapies
with
immune
checkpoint
inhibitors-further
refine
treatment
efficacy.
Nanoparticle-based
significantly
potential
making
them
promising
candidates
safer,
effective
treatments.
However,
challenges
related
regulatory
guidelines,
scalability,
long-term
safety
must
be
addressed
fully
realize
potential.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: March 23, 2023
Alternariol
is
a
toxic
metabolite
of
Alternaria
fungi
and
studies
have
shown
multiple
potential
pharmacological
effects.
To
outline
the
anticancer
effects
mechanisms
alternariol
its
derivatives
based
on
database
reports,
an
updated
search
PubMed/MedLine,
ScienceDirect,
Web
Science,
Scopus
databases
was
performed
with
relevant
keywords
for
published
articles.
The
found
to
suggest
that
this
mycotoxin
and/or
in
many
preclinical
test
systems.
Scientific
reports
indicate
exhibit
through
several
pathways,
including
cytotoxic,
reactive
oxygen
species
leading
oxidative
stress
mitochondrial
dysfunction-linked
cytotoxic
effect,
anti-inflammatory,
cell
cycle
arrest,
apoptotic
death,
genotoxic
mutagenic,
anti-proliferative,
autophagy,
estrogenic
clastogenic
mechanisms.
In
light
these
results,
may
be
one
hopeful
chemotherapeutic
agents.
Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: March 2, 2023
Abstract
Paeonia
emodi
Wall.
ex
Royle
is
commonly
known
as
Himalayan
paeony
has
great
importance
a
food
and
medicine.
The
practice
of
very
ancient
it
conventionally
used
for
wide
range
illnesses
in
the
folk
system
medicine
because
its
beneficial
phytochemical
profile.
main
purpose
current
review
was
synthesis
recent
data
on
botany,
ethnopharmacology,
phytochemistry
potential
pharmacological
mechanisms
action
Royle,
thus
offering
new
prospects
development
adjuvant
natural
therapies.
Using
scientific
databases
such
PubMed/MedLine,
Scopus,
Web
Science,
ScienceDirect,
Google
Scholar,
Springer,
Wiley,
comprehensive
literature
search
performed
Royle.
For
searching,
we
next
MeSH
terms:
“Biological
Product/isolation
purification”,
Products/pharmacology”,
“Drug
Discovery/methods”,
“Ethnopharmacology,
Medicine”,
“Traditional/methods”,
“Paeonia/chemistry”,
“Plant
Extracts/pharmacology”,
“Phytochemicals/chemistry”,
“Phytochemicals/pharmacology”,
“Plants,
Medicinal”.
results
most
studies
were
analyzed
important
summarized
tables
figures.
Phytochemical
research
led
to
isolation
triterpenes,
monoterpenes,
phenolic
acids,
fatty
organic
compounds,
steroids,
free
radicals
some
other
classes
primary
metabolites.
In
addition,
diverse
activities
like
antibacterial,
antifungal,
anticoagulant,
airway
relaxant
lipoxygenase
beta-glucuronidase
inhibiting
activity,
radical
scavenging
phytotoxic
insecticidal
have
been
reported
Different
bioactive
compounds
proven
their
therapeutic
modern
biomedical
cure
numerous
gastrointestinal
nervous
disorders.
future,
further
vitro
vivo
are
required
identify
action,
pharmacokinetics
studies,
pharmaceutical
formulations
target
transport
possible
interaction
with
allopathic
drugs.
Also,
regarding
quality
evaluation,
toxicity
safety
humans
needed.
Foods,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1488 - 1488
Published: May 11, 2024
Live
vinegar
is
a
product
formed
through
two-step
fermentation
process
of
sugar
substrate
that
has
not
been
subjected
to
filtration
or
pasteurization.
This
considered
preserve
all
nutrients
and
biologically
active
microorganisms,
making
it
with
valuable
composition
beneficial
properties.
Therefore,
the
purpose
this
study
was
analyze
chemical
antioxidant
properties
selected
vinegars
available
on
Polish
food
market.
The
material
in
consisted
four
live
(naturally
turbid,
unfiltered,
unpasteurized)
fruit
vegetable
vinegars:
apple,
pear,
rhubarb,
lemon.
Spectrophotometric,
HPLC,
GC
methods
were
used.
Among
tested,
lemon
had
highest
vitamin
C
content—15.95
mg/100
mL.
Apple
proved
be
best
source
polyphenols
flavonoids
(TPC—191.97
mg
GAE/L,
TFC—70.22
RE/L).
All
contained
dihydroxybenzoic
acid,
4-hydroxybenzoic
caffeic
2-hydroxycinnamic
myricetin.
acetic
acid
content
tested
ranged
from
29.180
38.125
mM/L.
pH
values
3.14
3.41.
In
conclusion,
most
promising
nutraceutical
potentially
health-promoting
seems
apple
vinegar.
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(9), P. 6070 - 6092
Published: June 18, 2024
Abstract
Diosmin,
a
potent
bioflavonoid
derived
from
citrus
fruits,
has
gained
significant
attention
for
its
anticancer
potential,
reflecting
critical
need
in
the
ongoing
battle
against
cancer.
Amidst
increasing
cancer
incidence,
quest
safer
and
more
effective
treatments
brought
diosmin
to
forefront,
given
unique
pharmacological
profile
distinct
other
flavonoids.
Diosmin's
mechanisms
are
multifaceted,
involving
apoptosis
induction,
angiogenesis
inhibition,
metastasis
prevention.
Extensive
research
encompassing
cellular
studies,
animal
models,
limited
clinical
trials
underscores
efficacy
not
only
but
also
managing
chronic
venous
insufficiency
hemorrhoids,
attributing
anti‐inflammatory
properties.
Furthermore,
exhibits
low
toxicity
complements
conventional
chemotherapy,
proposing
utility
as
an
adjunct
therapy
treatment
protocols.
The
review
delves
into
specific
advantages
of
diosmin,
distinguishing
it
broader
flavonoid
category.
It
provides
detailed
analysis
implications
preclinical
settings,
advocating
consideration
oncological
therapeutic
arsenal.
By
juxtaposing
with
herbal
medicines,
offers
nuanced
perspective
on
role
within
wider
context
natural
agents,
emphasizing
further
substantiate
safety
oncology.
Cancer Cell International,
Journal Year:
2022,
Volume and Issue:
22(1)
Published: Dec. 13, 2022
Colorectal
cancer
(CRC)
is
the
third
most
revalent
type
of
in
world
and
second
common
cause
death
(about
1
million
per
year).
Historically,
natural
compounds
their
structural
analogues
have
contributed
to
development
new
drugs
useful
treatment
various
diseases,
including
cancer.
Essential
oils
are
odorous
products
made
up
a
complex
mixture
low
molecular
weight
with
recognized
biological
pharmacological
properties
investigated
also
for
prevention
The
aim
this
paper
highlight
possible
role
essential
CRC,
composition
preclinical
studies
involving
them.
It
has
been
reviewed
determine
experimental
models
used
anticancer
potential
mechanisms
action
CRC.
Searches
were
performed
following
databases
PubMed/Medline,
Web
science,
TRIP
database,
Scopus,
Google
Scholar
using
appropriate
MeSH
terms.
results
analyzed
showed
that
EOs
exhibited
wide
range
bioactive
effects
like
cytotoxicity,
antiproliferative,
antimetastatic
on
cells
through
action.
This
updated
review
provides
better
quality
scientific
evidence
efficacy
as
chemotherapeutic/chemopreventive
agents
Future
translational
clinical
needed
establish
effective
dose
humans
well
suitable
route
administration
maximum
bioavailability
efficacy.
Given
positive
obtained
from
studies,
can
be
considered
efficient
complementary
therapies
chemotherapy
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
160, P. 114332 - 114332
Published: Feb. 1, 2023
In
the
modern
era,
cancer
can
be
controlled
by
chemotherapy
treatment,
and
in
many
situations
a
stable
disease
is
obtained.
The
significant
clinical
success
subsequent
commercialization
of
naturally
derived
molecules
have
further
encouraged
their
exploration
as
adjunctive
therapies
management.
purpose
this
comprehensive
review
to
update
anticancer
mechanisms
triggered
Erinacine
A
regulation
signaling
pathways
potentially
involved
its
activity.The
results
preclinical
research
showed
that
Erinacin
A,
therapeutically
important
biological
metabolite
isolated
from
basidiomycete
fungus
Hericium
erinaceus
offers
multitude
possible
chemotherapeutic
applications
regulating
complex
validated
various
pharmacological
vitro
vivo
studies.
As
result
A's
action
on
oncological
pathways,
it
resulted
induction
apoptosis,
reduction
proliferation,
invasiveness,
generation
oxidative
stress
cell
cycle
arrest
cells.