Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 23, 2024

Introduction: Based on extensive data from oncology research, the use of phytochemicals or plant-based nutraceuticals is considered an innovative tool for cancer management. This research aimed to analyze oncostatic properties Salvia officinalis L. [Lamiaceae; Salviae herba] using animal and in vitro models breast carcinoma (BC). Methods: The effects dietary administered S. two concentrations (0.1%/SAL 0.1/and 1%/SAL 1/) were assessed both syngeneic 4T1 mouse chemically induced rat BC. histopathological molecular evaluations rodent specimens performed after autopsy. Besides, numerous analyses human cell lines performed. Results Conclusion: dominant metabolites found propylene glycol extract (SPGE) representatives phenolics, specifically rosmarinic, protocatechuic, salicylic acids. Furthermore, occurrence triterpenoids ursolic oleanolic acid was proved SPGE. In a model, non-significant tumor volume decrease treatment associated with significant reduction mitotic activity index tumors by 37.5% (SAL 0.1) 31.5% 1) vs. controls (set as blank group not applied salvia diet). addition, at higher doses significantly decreased necrosis/whole area ratio 46% when compared control samples. chemoprevention study, dose lengthened latency 8.5 days improved high/low-grade carcinomas doses. Analyses mechanisms anticancer activities S . included well-validated prognostic, predictive, diagnostic biomarkers that are practice preclinical investigation. Our assessment vivo revealed changes comparison treated untreated cells. this regard, we overexpression caspase-3, increased Bax/Bcl-2 ratio, MDA, ALDH1, EpCam expression. reduced TGF-β serum levels rats (decrease IL-6 TNF-α borderline significance). Evaluation epigenetic modifications decline lysine methylations H3K4m3 increase acetylation H4K16ac groups. relative oncogenic miR21 tumor-suppressive miR145 (miR210, miR22, miR34a, miR155 altered). methylation ATM PTEN promoters ( PITX2, RASSF1 , TIMP3 Analyzing plasma metabolomics profile tumor-bearing rats, ketoacids derived BCAAs treatment. anti-cancer SPGE MCF‐7 MDA-MB-231 (cytotoxicity, caspase‐3/-7, Bcl‐2, Annexin V/PI, cycle, BrdU, mitochondrial membrane potential). study demonstrates chemopreventive haulm BC models.

Language: Английский

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Inhibition of MMP-2 and MMP-9 by Dietary Antioxidants in THP-1 Macrophages and Sera from Patients with Breast Cancer

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1718 - 1718

Published: April 10, 2024

Polyphenols, the main antioxidants of diet, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared effects four polyphenolic compounds on ROS production levels matrix metalloproteinase (MMP)-2 -9, which represent important pathogenetic factors breast cancer. THP-1 differentiated macrophages were activated by LPS simultaneously treated with different doses a green tea extract (GTE), resveratrol (RSV), curcumin (CRC) an olive fruit (oliplus). By using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, found that all tested showed activity in vitro. In addition, GTE, RSV CRC able to counteract induced H

Language: Английский

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Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: March 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Language: Английский

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Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and treatments past decade; however, complexity heterogeneity certain breast subtypes often lead to drug resistance metastatic progression. Owing their low toxicity high variety, natural products derivatives are becoming increasingly valuable sources for small‐molecule anticancer drugs. Polyphenols more widely known role prevention as adjuvants conventional treatment strategies. Therefore, this review focuses on antitumor effects curcumin, resveratrol, polydatin cancer. According main databases, only vitro preclinical studies with solid scientific backgrounds reports protective were included. Curcumin, antioxidant, anti‐inflammatory, effects; indeed, they improve efficacy; reduce chemoresistance, angiogenesis, tumor growth; induce apoptosis, autophagy, cell cycle arrest through multiple molecular pathways, including suppression epithelial–mesenchymal transition (EMT), NF‐κB, PI3K/Akt/mTOR, c‐Jun N‐terminal kinase (JNK), MAPK, ERK1/2, STAT signaling pathways; inhibition cyclins matrix metalloproteinase (MMP)‐2 MMP‐9; activation p53 microtubule‐associated protein light chain 3 (LC3).

Language: Английский

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An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects mechanisms alternariol its derivatives based on database reports, an updated search PubMed/MedLine, ScienceDirect, Web Science, Scopus databases was performed with relevant keywords for published articles. The found to suggest that this mycotoxin and/or in many preclinical test systems. Scientific reports indicate exhibit through several pathways, including cytotoxic, reactive oxygen species leading oxidative stress mitochondrial dysfunction-linked cytotoxic effect, anti-inflammatory, cell cycle arrest, apoptotic death, genotoxic mutagenic, anti-proliferative, autophagy, estrogenic clastogenic mechanisms. In light these results, may be one hopeful chemotherapeutic agents.

Language: Английский

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A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: March 2, 2023

Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.

Language: Английский

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The Chemical Profiles and Antioxidant Properties of Live Fruit or Vegetable Vinegars Available on the Polish Food Market

Foods, Journal Year: 2024, Volume and Issue: 13(10), P. 1488 - 1488

Published: May 11, 2024

Live vinegar is a product formed through two-step fermentation process of sugar substrate that has not been subjected to filtration or pasteurization. This considered preserve all nutrients and biologically active microorganisms, making it with valuable composition beneficial properties. Therefore, the purpose this study was analyze chemical antioxidant properties selected vinegars available on Polish food market. The material in consisted four live (naturally turbid, unfiltered, unpasteurized) fruit vegetable vinegars: apple, pear, rhubarb, lemon. Spectrophotometric, HPLC, GC methods were used. Among tested, lemon had highest vitamin C content—15.95 mg/100 mL. Apple proved be best source polyphenols flavonoids (TPC—191.97 mg GAE/L, TFC—70.22 RE/L). All contained dihydroxybenzoic acid, 4-hydroxybenzoic caffeic 2-hydroxycinnamic myricetin. acetic acid content tested ranged from 29.180 38.125 mM/L. pH values 3.14 3.41. In conclusion, most promising nutraceutical potentially health-promoting seems apple vinegar.

Language: Английский

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Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(9), P. 6070 - 6092

Published: June 18, 2024

Abstract Diosmin, a potent bioflavonoid derived from citrus fruits, has gained significant attention for its anticancer potential, reflecting critical need in the ongoing battle against cancer. Amidst increasing cancer incidence, quest safer and more effective treatments brought diosmin to forefront, given unique pharmacological profile distinct other flavonoids. Diosmin's mechanisms are multifaceted, involving apoptosis induction, angiogenesis inhibition, metastasis prevention. Extensive research encompassing cellular studies, animal models, limited clinical trials underscores efficacy not only but also managing chronic venous insufficiency hemorrhoids, attributing anti‐inflammatory properties. Furthermore, exhibits low toxicity complements conventional chemotherapy, proposing utility as an adjunct therapy treatment protocols. The review delves into specific advantages of diosmin, distinguishing it broader flavonoid category. It provides detailed analysis implications preclinical settings, advocating consideration oncological therapeutic arsenal. By juxtaposing with herbal medicines, offers nuanced perspective on role within wider context natural agents, emphasizing further substantiate safety oncology.

Language: Английский

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Natural essential oils as a new therapeutic tool in colorectal cancer

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: Dec. 13, 2022

Colorectal cancer (CRC) is the third most revalent type of in world and second common cause death (about 1 million per year). Historically, natural compounds their structural analogues have contributed to development new drugs useful treatment various diseases, including cancer. Essential oils are odorous products made up a complex mixture low molecular weight with recognized biological pharmacological properties investigated also for prevention The aim this paper highlight possible role essential CRC, composition preclinical studies involving them. It has been reviewed determine experimental models used anticancer potential mechanisms action CRC. Searches were performed following databases PubMed/Medline, Web science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. results analyzed showed that EOs exhibited wide range bioactive effects like cytotoxicity, antiproliferative, antimetastatic on cells through action. This updated review provides better quality scientific evidence efficacy as chemotherapeutic/chemopreventive agents Future translational clinical needed establish effective dose humans well suitable route administration maximum bioavailability efficacy. Given positive obtained from studies, can be considered efficient complementary therapies chemotherapy

Language: Английский

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Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114332 - 114332

Published: Feb. 1, 2023

In the modern era, cancer can be controlled by chemotherapy treatment, and in many situations a stable disease is obtained. The significant clinical success subsequent commercialization of naturally derived molecules have further encouraged their exploration as adjunctive therapies management. purpose this comprehensive review to update anticancer mechanisms triggered Erinacine A regulation signaling pathways potentially involved its activity.The results preclinical research showed that Erinacin A, therapeutically important biological metabolite isolated from basidiomycete fungus Hericium erinaceus offers multitude possible chemotherapeutic applications regulating complex validated various pharmacological vitro vivo studies. As result A's action on oncological pathways, it resulted induction apoptosis, reduction proliferation, invasiveness, generation oxidative stress cell cycle arrest cells.

Language: Английский

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