Gonorrhoeae must Compete with the Naturally Inhabitant of Microbial Community Right at the Outer Mucosal Surface to Authorize Infection DOI Open Access
Lusia Sri Sunarti

International Journal of Pathogen Research, Journal Year: 2023, Volume and Issue: 12(6), P. 55 - 66

Published: Oct. 28, 2023

Aim: to describe the competition between Neisseria gonorrhoeae with naturally inhabitant of microbial community right at outer mucosal surface authorize infection. Discussion: Gonorrhea is a sexually transmitted infection (STI) caused by bacterium N. gonorrhea. Official report mention that year 2020, there were an estimated 82.4 million new infections among adults globally and poses risk onward transmission sex partners. It surely could affect both men women; for male, symptoms are more obvious, but women it occurs often without prominent clinical usually lead long-term health problems including pelvic inflammatory disease infertility. The female reproductive tract its abundant variety epithelial cells act as primary niche where initially was inhabited normal microbiota, characterized high abundance Lactobacilli, uniquely linked host’s immunity plays critical role in regulation genital inflammation. Unfortunately, dynamics regarding number composition vaginal microbiota has been shown fluctuate over several internal external factors, especially due STI like Its proposed evolution from ancestral commensal bacterium, retained features commonly found inhabitants, also developed unique crucial pathogenesis. scope pathogenesis field elucidate competition, colonization growth properties main virulence determinants. Conclusion: Competition already exist natural vagina occur surface. This gonococcus intrinsic factors can facilitate competitiveness adherence, even though not all available adhesion mechanisms actually used this organism during course infection/colonization any specific site.

Language: Английский

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy DOI Creative Commons
Qian Cheng, Xiao‐Lei Shi, Qilin Li

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(3)

Published: Nov. 8, 2023

Abstract Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis over oxidative phosphorylation to provide a vast amount energy for fast proliferation even under oxygen‐sufficient conditions. This metabolic alteration not only favors cell progression and metastasis but also increases lactate accumulation in solid tumors. In addition serving as byproduct glycolytic cells, plays central role the construction acidic immunosuppressive microenvironment, resulting therapeutic tolerance. Recently, targeted drug delivery inherent properties nanomaterials attracted great attention, research on modulating metabolism based enhance antitumor therapy has exploded. this review, advanced strategies interfere with are discussed, including inhibiting anabolism, promoting catabolism, disrupting “lactate shuttle”. Furthermore, recent advances combining modulation other therapies, chemotherapy, immunotherapy, photothermal therapy, reactive oxygen species‐related etc., which achieved cooperatively enhanced outcomes, summarized. Finally, foreseeable challenges prospective developments reviewed future development field.

Language: Английский

Citations

23
Disrupting glycolysis and DNA repair in anaplastic thyroid cancer with nucleus-targeting platinum nanoclusters DOI
Zongfu Pan, Xixuan Lu, Xi Hu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 369, P. 517 - 530

Published: April 8, 2024

Language: Английский

Citations

4
Emerging posttranslational modifications and their roles in DNA damage response DOI Creative Commons
Zhen Wu, Yajing Liu, Meng Zhang

et al.

Genome Instability & Disease, Journal Year: 2023, Volume and Issue: 5(1), P. 1 - 16

Published: Nov. 20, 2023

Abstract Posttranslational modifications (PTMs), occurring on various histones and nonhistone proteins, greatly enrich the diversity of proteome, thereby profoundly affecting protein structures biological functions. Histones are particularly important components genomic chromatin their represent a critical event in control DNA damage response (DDR) induced by endogenous or exogenous insults. Extensive studies have revealed roles classical PTMs including phosphorylation, acetylation ubiquitination, modulating dynamics through recruitment remodeling complex repair machinery during DDR process, thus successfully maintaining genome stability preventing cells from adverse fates such as apoptosis malignant transformation. In recent years, several novel PTMs, ufmylation, crotonylation, succinylation lactylation, been discovered both proteins. Their potential regulatory mechanisms process indeed emerged, but still far completely understood. This review primarily focuses regulation DDR, further discusses networks cell to interplay between diverse response, which aims expand understanding involved provides insights into disease intervention.

Language: Английский

Citations

5
Whole grain metabolite 3,5-dihydroxybenzoic acid is a beneficial nutritional molecule with the feature of a double-edged sword in human health: a critical review and dietary considerations DOI
W. C. Wagner, Katarzyna Sobierajska, Łukasz Pułaski

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(24), P. 8786 - 8804

Published: April 25, 2023

Nonprocessed foodstuffs of plant origin, especially whole-grain cereals, are considered to be health-promoting components the human diet. While most their well-studied effects derive from high fiber content and low glycemic index, presence underrated phenolic phytonutrients has recently been brought attention nutritionists. In this review, we report discuss findings on sources bioactivities 3,5-dihydroxybenzoic acid (3,5-DHBA), which is both a direct dietary component (found, e.g., in apples) and, more importantly, crucial metabolite cereal-derived alkylresorcinols (ARs). 3,5-DHBA described exogenous agonist HCAR1/GPR81 receptor. We concentrate HCAR1-mediated nervous system, maintenance cell stemness, regulation carcinogenesis, response anticancer therapy. Unexpectedly, malignant tumors take advantage HCAR1 expression sense support growth. Thus, there an urgent need fully identify role whole-grain-derived during therapy its contribution vital organs body via specific here detail possible consequences modulatory capabilities physiological pathological conditions humans.

Language: Английский

Citations

5
The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer DOI

Shiqi Dong,

Chao Chen, Di Chang

et al.

Current Cancer Drug Targets, Journal Year: 2024, Volume and Issue: 24(12), P. 1195 - 1212

Published: Feb. 16, 2024

NADPH oxidase, as a major source of intracellular reactive oxygen species (ROS), assumes an important role in the immune response and oxidative stress body. oxidase 2 (NOX2) is first most representative member family, its effects on development tumor cells are gaining more attention. Our previous study suggested that NCF4 polymorphism p40phox, key subunit NOX2, affected outcome diffuse large B-cell lymphoma patients treated with rituximab. It hypothesized NOX2-mediated ROS could enhance cytotoxic some anti-tumor drugs favor tumors. Several reviews have summarized NOX2 congeners-mediated therapy, but few studies focused relationship between expression drug resistance. In this article, we systematically introduced NOX represented by classification latest inhibitors agonists NOX2. will help researchers to rational objective understanding dual resistance expected provide new ideas for oncology treatment overcoming cancer.

Language: Английский

Citations

1
Gonorrhoeae must Compete with the Naturally Inhabitant of Microbial Community Right at the Outer Mucosal Surface to Authorize Infection DOI Open Access
Lusia Sri Sunarti

International Journal of Pathogen Research, Journal Year: 2023, Volume and Issue: 12(6), P. 55 - 66

Published: Oct. 28, 2023

Aim: to describe the competition between Neisseria gonorrhoeae with naturally inhabitant of microbial community right at outer mucosal surface authorize infection. Discussion: Gonorrhea is a sexually transmitted infection (STI) caused by bacterium N. gonorrhea. Official report mention that year 2020, there were an estimated 82.4 million new infections among adults globally and poses risk onward transmission sex partners. It surely could affect both men women; for male, symptoms are more obvious, but women it occurs often without prominent clinical usually lead long-term health problems including pelvic inflammatory disease infertility. The female reproductive tract its abundant variety epithelial cells act as primary niche where initially was inhabited normal microbiota, characterized high abundance Lactobacilli, uniquely linked host’s immunity plays critical role in regulation genital inflammation. Unfortunately, dynamics regarding number composition vaginal microbiota has been shown fluctuate over several internal external factors, especially due STI like Its proposed evolution from ancestral commensal bacterium, retained features commonly found inhabitants, also developed unique crucial pathogenesis. scope pathogenesis field elucidate competition, colonization growth properties main virulence determinants. Conclusion: Competition already exist natural vagina occur surface. This gonococcus intrinsic factors can facilitate competitiveness adherence, even though not all available adhesion mechanisms actually used this organism during course infection/colonization any specific site.

Language: Английский

Citations

1