Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease DOI Creative Commons
Nasrin Mehranfard, Maedeh Ghasemi, Arezoo Rajabian

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(12), P. e22820 - e22820

Published: Nov. 25, 2023

Increasing evidence suggests that elevated intracellular levels of reactive oxygen species (ROS) play a significant role in the pathogenesis many diseases. Increased ROS can lead to oxidation lipids, DNA, and proteins, contributing cellular damage. Hence, maintenance redox hemostasis is essential. Naringenin (NAR) flavonoid included flavanones subcategory. Various pharmacological actions have been ascribable this phytochemical composition, including antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, antiadipogenic, neuro-, cardio-protective activities. This review focused on underlying mechanism responsible for antioxidative stress properties NAR its' nanoformulations. Several lines vitro vivo investigations suggest effects its nanoformulation their target cells via modulating signaling pathways. These nanoformulations include nanoemulsion, nanocarriers, solid lipid nanoparticles (SLN), nanomicelle. also highlights several beneficial health human diseases brain disorders, cancer, rheumatoid arthritis, small intestine injuries. Employing improve pharmacokinetic consequently efficiency by reducing limitations, such as low bioavailability. The protective against oxidative may be linked modulation Nrf2-heme oxygenase-1, NO/cGMP/potassium channel, COX-2, NF-κB, AMPK/SIRT3, PI3K/Akt/mTOR, BDNF, NOX, LOX-1 Understanding behind facilitate drug development treatment stress-related disorders.

Language: Английский

Neuroinflammatory mediators in acquired epilepsy: an update DOI
Yu Chen, Marwa M. Nagib,

Nelufar Yasmen

et al.

Inflammation Research, Journal Year: 2023, Volume and Issue: 72(4), P. 683 - 701

Published: Feb. 6, 2023

Language: Английский

Citations

59
Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression DOI Creative Commons
Lucas Fornari Laurindo, Jefferson Aparecido Dias, Adriano Cressoni Araújo

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

The increasing life expectancy has led to a higher incidence of age-related neurodegenerative conditions. Within this framework, neuroinflammation emerges as significant contributing factor. It involves the activation microglia and astrocytes, leading release pro-inflammatory cytokines chemokines infiltration peripheral leukocytes into central nervous system (CNS). These instances result in neuronal damage neurodegeneration through activated nucleotide-binding domain leucine-rich repeat containing (NLR) family pyrin protein 3 (NLRP3) nuclear factor kappa B (NF-kB) pathways decreased erythroid 2-related 2 (Nrf2) activity. Due limited effectiveness regarding inhibition neuroinflammatory targets using conventional drugs, there is challenging growth search for innovative therapies alleviating CNS diseases or even before their onset. Our results indicate that interventions focusing on Interleukin-Driven Immunomodulation, Chemokine (CXC) Receptor Signaling Expression, Cold Exposure, Fibrin-Targeted strategies significantly promise mitigate processes. approaches demonstrate potential anti-neuroinflammatory effects, addressing conditions such Multiple Sclerosis, Experimental autoimmune encephalomyelitis, Parkinson’s Disease, Alzheimer’s Disease. While findings are promising, immunomodulatory often face limitations due Immune-Related Adverse Events. Therefore, conduction randomized clinical trials matter mandatory, will pave way promising future development new medicines with specific therapeutic targets.

Language: Английский

Citations

47
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review) DOI Creative Commons
Pei Qin,

Ye Sun,

Liya Li

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 53(5)

Published: April 2, 2024

Chronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators neuroinflammation. In addition to providing energy cells, mitochondria also participate immunoinflammatory response disorders including Alzheimer's disease, Parkinson's multiple sclerosis epilepsy, by regulating processes such cell death inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, dynamics calcium homeostasis imbalance may underlying regulatory mechanisms for these diseases. Therefore, investigating related dysfunction result therapeutic strategies against chronic neurodegeneration. The present review summarizes neuroinflammatory diseases current treatment approaches that target

Language: Английский

Citations

16
The MC-LR induced neuroinflammation and the disorders of neurotransmitter system in zebrafish (Danio rerio): Oxidative stress as a key DOI
Ya He,

Kang Ou-Yang,

Hui Yang

et al.

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: 158, P. 110126 - 110126

Published: Jan. 15, 2025

Language: Английский

Citations

1
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration DOI Creative Commons
Dong Liu, Hannah C. Webber,

Fuyun Bian

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 20, 2025

Optineurin (OPTN) mutations are linked to amyotrophic lateral sclerosis (ALS) and normal tension glaucoma (NTG), but a relevant animal model is lacking, the molecular mechanisms underlying neurodegeneration unknown. We find that OPTN C-terminus truncation (OPTN∆C) causes late-onset of retinal ganglion cells (RGCs), optic nerve (ON), spinal cord motor neurons, preceded by decrease axonal mitochondria in mice. discover directly interacts with both microtubules mitochondrial transport complex TRAK1/KIF5B, stabilizing them for proper anterograde transport, dependent manner. Furthermore, overexpressing OPTN/TRAK1/KIF5B prevents not only truncation-induced, also ocular hypertension-induced neurodegeneration, promotes robust ON regeneration. Therefore, addition generating models NTG ALS, our results establish as facilitator microtubule-dependent necessary adequate delivery, its loss likely mechanism neurodegeneration.

Language: Английский

Citations

1
Behavioral and Biochemical Insights into the Therapeutic Potential of Mitocurcumin in a Zebrafish–Pentylenetetrazole (PTZ) Epilepsy Model DOI Creative Commons

Alin Dumitru Ciubotaru,

Carmen-Ecaterina Leferman, Bogdan Ignat

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 382 - 382

Published: March 7, 2025

Background/Objectives: Epilepsy is a complex neurological disorder with strong link to oxidative stress, which contributes seizure susceptibility and neuronal damage. This study aims investigate the effects of curcumin (Cur), sodium valproate (VPA), mitocurcumin (MitoCur), mitochondria-targeted curcumin, on behavioral stress parameters in zebrafish model pentylenetetrazole (PTZ)-induced seizures. Methods: Adult were exposed two concentrations (0.25 0.5 µM for Cur MitoCur; 0.25 mM VPA). Behavioral assessments, including locomotion, spatial exploration, directional movement, conducted using EthoVision XT tracking software. Oxidative markers, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx), total antioxidant status (TAS), analyzed brain homogenates. Results: analyses indicated dose-dependent effects, higher doses generally reducing activity. MitoCur at enhanced defenses reduced damage, while exhibited pro-oxidant shift. VPA improved TAS without significantly altering MDA levels. Conclusions: These findings emphasize importance dose optimization antioxidant-based epilepsy treatments highlight potential as targeted therapeutic option.

Language: Английский

Citations

1
Alpha-Lipoic Acid as an Antioxidant Strategy for Managing Neuropathic Pain DOI Creative Commons
Max Denisson Maurı́cio Viana, Pedro Santana Sales Lauria, Alyne Almeida de Lima

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(12), P. 2420 - 2420

Published: Dec. 8, 2022

Neuropathic pain (NP) is the most prevalent and debilitating form of chronic pain, caused by injuries or diseases somatosensory system. Since current first-line treatments only provide poor symptomatic relief, search for new therapeutic strategies managing NP an active field investigation. Multiple mechanisms contribute to genesis maintenance NP, including damage oxidative stress. The naturally occurring antioxidant alpha-lipoic acid (ALA) a promising agent management NP. Several pre-clinical in vitro vivo studies as well clinical trials demonstrate analgesic potential ALA beneficial biological activities are reflected various patents development ALA-based innovative products. This review demonstrates discussing its effects multiple use patented products how technological approaches have been applied enhance ALA’s pharmacological properties.

Language: Английский

Citations

31
Noise-induced auditory damage affects hippocampus causing memory deficits in a model of early age-related hearing loss DOI Creative Commons
Fabiola Paciello, Anna Pisani, Marco Rinaudo

et al.

Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 178, P. 106024 - 106024

Published: Jan. 29, 2023

Several studies identified noise-induced hearing loss (NIHL) as a risk factor for sensory aging and cognitive decline processes, including neurodegenerative diseases, such dementia age-related (ARHL). Although the association between noise- age-induced impairment has been widely documented by epidemiological experimental studies, molecular mechanisms underlying this are not fully understood it is known how these factors (aging noise) can interact, affecting memory processes. We recently found that early noise exposure in an established animal model of ARHL (C57BL/6 mice) accelerates onset cochlear dysfunctions. Here, we extended our previous data investigating what happens central brain structures (auditory cortex hippocampus), to assess relationship possible combined effect on domain. To aim, exposed juvenile C57BL/6 mice 2 months age repeated sessions (60 min/day, pure tone 100 dB SPL, 10 kHz, consecutive days) monitored auditory threshold measuring brainstem responses (ABR), spatial working memory, using Y-maze test, basal synaptic transmission ex vivo electrophysiological recordings, at different time points (1, 4 7 after exposure, corresponding 3, 6 9 age). loss, along with accelerated presbycusis onset, induce persistent alterations cortex. This was associated decreased performance oxidative-inflammatory injury hippocampus, extra-auditory structure involved Collectively, confirm critical circuits, suggesting detrimental function be considered high-risk both degenerative given phenotype induces hippocampal-dependent

Language: Английский

Citations

20
IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions DOI Open Access

Anton Shkundin,

Angelos Halaris

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 488 - 488

Published: May 3, 2024

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological psychiatric health. It exerts a profound effect on immune cell activation brain function, suggesting potential roles in both neuroprotection neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation disease progression. Additionally, CXCL8 gene polymorphisms can alter production, leading differences susceptibility, progression, severity across populations. levels vary among neuropsychiatric conditions, demonstrating sensitivity psychosocial stressors severity. be detected blood circulation, cerebrospinal fluid (CSF), urine, making it promising candidate for broad-spectrum biomarker. This review highlights the need further research diverse effects of associated implications personalized medicine. A thorough understanding its complex role could lead development more effective treatment strategies conditions.

Language: Английский

Citations

7
Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells DOI
Fen Li, Lin Zhang, Xingxu Zhang

et al.

NeuroToxicology, Journal Year: 2024, Volume and Issue: 104, P. 1 - 10

Published: July 18, 2024

Language: Английский

Citations

5