Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: April 5, 2023
Abstract
Background
Rhegmatogenous
retinal
detachment
associated
with
choroidal
(RRDCD)
is
a
complex
type
of
detachment.
This
disease
characterized
by
high
difficulty
operation
and
poor
prognosis.
However,
the
pathogenesis
still
unclear.
The
purpose
this
study
was
to
analyze
changes
metabolites
metabolic
pathways
in
vitreous
fluid
RRDCD
patients.
Method
Using
ultra-high-performance
liquid
chromatography
coupled
quadrupole
time-of-flight
mass
spectrometry
method,
idiopathic
epimacular
membrane
(IEMM)
patients
were
analyzed.
A
total
28
samples
analyzed
compare
significance
different
between
these
groups.
Results
We
identified
135
IEMM
groups
(VIP
>
1,
P
value
<
0.05).
Compared
group,
level
sphingomyelin,
adenosine,
L-palmitoylcarnitine
4,7,10,13,1
6,19-docosahexaenoic
acid
up-regulated
group.
series
lipid
main
involved
protein
digestion
absorption,
ABC
transporters,
aminoacyl-tRNA
biosynthesis,
central
carbon
metabolism
cancer
sphingolipids
metabolism.
Conclusions
Our
results
suggest
that
up-regulation
sphingomyelin
abnormal
may
induce
cell
migration
death
after
or
And
then,
it
intraocular
inflammation
damage
visual
function.
accumulated
fatty
energy
pathway
retina,
aggravate
photoreceptors
hypoxia.
These
provide
clues
for
studying
mechanism,
treatment
prognosis
RRDCD.
Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(4), P. 635 - 635
Published: April 5, 2023
Oxidation
of
lipids
and
lipoproteins
contributes
to
inflammation
processes
that
promote
the
development
eye
diseases.
This
is
a
consequence
metabolism
dysregulation;
for
instance,
dysfunctional
peroxisomal
lipid
metabolism.
Dysfunction
peroxidation
critical
factor
in
oxidative
stress
causes
ROS-induced
cell
damage.
Targeting
treat
ocular
diseases
an
interesting
effective
approach
now
being
considered.
Indeed,
among
structures,
retina
fundamental
tissue
shows
high
Lipids
glucose
are
fuel
substrates
photoreceptor
mitochondria;
therefore,
rich
lipids,
especially
phospholipids
cholesterol.
The
imbalance
cholesterol
homeostasis
accumulation
human
Bruch's
membrane
related
diseases,
such
as
AMD.
In
fact,
preclinical
tests
performed
mice
models
with
AMD,
making
this
area
promising
field.
Nanotechnology,
on
other
hand,
offers
opportunity
develop
site-specific
drug
delivery
systems
tissues
treatment
Specially,
biodegradable
nanoparticles
constitute
treating
metabolic
eye-related
pathologies.
Among
several
systems,
show
attractive
properties,
e.g.,
no
toxicological
risk,
easy
scale-up
increased
bioavailability
loaded
active
compounds.
review
analyses
mechanisms
involved
dyslipidemia,
well
their
manifestations.
Moreover,
compounds
which
aim
target
retinal
metabolism-related
thoroughly
discussed.
At
preterm
birth,
the
retina
is
incompletely
vascularized.
Retinopathy
of
prematurity
(ROP)
initiated
by
postnatal
suppression
physiological
retinal
vascular
development
that
would
normally
occur
in
utero.
As
neural
slowly
matures,
increasing
metabolic
demand
including
peripheral
avascular
retina,
leads
to
signals
for
compensatory
but
pathological
neovascularization.
Currently,
only
late
neovascular
ROP
treated.
could
be
prevented
promoting
normal
growth.
Early
perinatal
dysregulation
a
strong
understudied
risk
factor
and
other
long-term
sequelae
birth.
We
will
discuss
oxygen
needs
current
treatments,
potential
interventions
promote
vessel
growth
control
hyperglycemia,
dyslipidemia
hyperoxia-induced
alterations.
supplementation
missing
nutrients
factors
supplemental
promotes
development.
knowledge
gap
metabolism
after
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Dyslipidemia
contributes
to
many
retinal
diseases,
but
underlying
lipid
processing
pathways
are
not
fully
understood.
Peroxisomes
oxidize
very
long-chain
fatty
acids
and
generate
docosahexaenoic
acid
(DHA).
Mutations
in
peroxisomal
genes
can
result
severe
neural
dysfunction.
However,
therapeutic
approaches
for
diseases
remain
scarce,
dietary
strategies
yield
inconsistent
results.
This
study
sought
elucidate
metabolic
adaptations
resulting
from
impaired
oxidation
evaluate
the
potential
of
nutrient
supplementation
disease.
In
mice
with
global
knockout
(KO)
acyl-coenzyme
A
oxidase
1
(Acox1),
encoding
first
rate-limiting
enzyme
oxidation,
retina
was
characterized
at
postnatal
day
(P)
30
during
development.
Retinal
thickness,
photoreceptor
structure,
function
were
examined.
Proteome
analysis
utilized
molecular
mechanistic
investigation.
Metabolomics
profiling
conducted
alterations
retina.
Nutrient
intervention
performed
test
if
providing
deficient
nutrients
could
attenuate
observed
P30
Acox1
KO
mice,
we
signaling,
accompanied
by
reduced
expression
involved
phototransduction.
Proteomics
suggested
diminished
glucose
mitochondrial
metabolism,
supported
decreased
number
DNA
copy
number.
showed
abundance
pyruvate,
pyruvate
P30-P60
attenuated
dysfunction
P60.
Furthermore,
exhibited
a
significant
decrease
omega-3
(n-3)
compensatory
increase
n-6
acids.
Dietary
DHA
or
plus
arachidonic
(n-6)
mitigated
progression
mice.
dysfunction,
number,
imbalance
oxidation.
may
offer
promising
approach
diseases.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(5), P. 1056 - 1056
Published: May 6, 2023
The
excessive
generation
of
reactive
oxygen
species
(ROS)
plays
a
pivotal
role
in
the
pathogenesis
diseases.
ROS
are
central
to
cellular
redox
regulation
and
act
as
second
messengers
activate
redox-sensitive
signals.
Recent
studies
have
revealed
that
certain
sources
can
be
beneficial
or
harmful
human
health.
Considering
essential
pleiotropic
roles
basic
physiological
functions,
future
therapeutics
should
designed
modulate
state.
Dietary
phytochemicals,
microbiota,
metabolites
derived
from
them
expected
developed
drugs
prevent
treat
disorders
tumor
microenvironment.
Molecular Metabolism,
Journal Year:
2024,
Volume and Issue:
88, P. 101995 - 101995
Published: July 22, 2024
Mutations
in
Tissue
Inhibitor
of
Metalloproteinases
3
(TIMP3)
cause
Sorsby's
Fundus
Dystrophy
(SFD),
a
dominantly
inherited,
rare
form
macular
degeneration
that
results
vision
loss.
TIMP3
is
synthesized
primarily
by
retinal
pigment
epithelial
(RPE)
cells,
which
constitute
the
outer
blood-retinal
barrier.
One
major
function
RPE
synthesis
and
transport
vital
nutrients,
such
as
glucose,
to
retina.
Recently,
metabolic
dysfunction
cells
has
emerged
an
important
contributing
factor
degenerations.
We
set
out
determine
if
was
SFD
pathogenesis.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 6, 2024
Abstract
Mutations
in
Tissue
Inhibitor
of
Metalloproteinases
3
(TIMP3)
cause
Sorsby’s
Fundus
Dystrophy
(SFD),
a
dominantly
inherited,
rare
form
macular
degeneration
that
results
vision
loss.
TIMP3
is
synthesized
primarily
by
retinal
pigment
epithelial
(RPE)
cells,
which
constitute
the
outer
blood-retinal
barrier.
Quantitative
proteomics
and
RNAseq
analysis
on
choroid/RPE
mice
expressing
mutant
identified
dysregulation
metabolic
processes.
We
examined
effects
RPE
metabolism
using
human
ARPE-19
cells
S179C
patient-derived
induced
pluripotent
stem
cell-derived
(iRPE)
carrying
S204C
mutation.
Stable
isotope
tracing
experiments
demonstrated
enhanced
glucose
utilization
glycolytic
activity
concomitantly
with
altered
glutamine
utilization.
This
study
provides
important
information
metabolome
SFD
implicates
potential
commonality
other
degenerative
diseases,
emphasizing
cellular
as
therapeutic
target.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 24, 2024
Abstract
Mutations
in
Tissue
Inhibitor
of
Metalloproteinases
3
(TIMP3)
cause
Sorsby’s
Fundus
Dystrophy
(SFD),
a
dominantly
inherited,
rare
form
macular
degeneration
that
results
vision
loss.
TIMP3
is
synthesized
primarily
by
retinal
pigment
epithelial
(RPE)
cells,
which
constitute
the
outer
blood-retinal
barrier.
Quantitative
proteomics
and
RNAseq
analysis
on
choroid/RPE
mice
expressing
mutant
identified
dysregulation
metabolic
processes.
We
examined
effects
RPE
metabolism
using
human
ARPE-19
cells
S179C
patient-derived
induced
pluripotent
stem
cell-derived
(iRPE)
carrying
S204C
mutation.
Stable
isotope
tracing
experiments
demonstrated
enhanced
glucose
utilization
glycolytic
activity
concomitantly
with
altered
glutamine
utilization.
This
study
provides
important
information
metabolome
SFD
implicates
potential
commonality
other
degenerative
diseases,
emphasizing
cellular
as
therapeutic
target.
