Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers DOI Open Access

BINGJIE LI,

WENBO CAO,

JINJING XIAO

et al.

Biocell, Journal Year: 2024, Volume and Issue: 48(6), P. 923 - 934

Published: Jan. 1, 2024

Perineural invasion (PNI), a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread, has the capacity to extend well beyond primary site, infiltrating distant regions devoid vascular structures.PNI often heralds decrease in patient survival rates and is recognized as an indicator unfavorable prognosis across variety cancers.Despite its clinical significance, underlying molecular mechanisms PNI remain elusive, complicating development specific efficacious diagnostic therapeutic strategies.In realm cancer research, non-coding RNAs (ncRNAs) have attracted considerable attention due their multifaceted roles cancer-specific expression profiles, positioning them promising candidates for applications diagnostics, prognostics, treatment.Among various types ncRNAs, microRNAs (miRNAs), long (lncRNAs), circular (circRNAs) emerged influential players PNI.Their involvement increasingly contributing factor progression resistance.Our study synthesizes explores diverse functions ncRNAs relation cancer.This comprehensive review aims shed light on cutting-edge perspectives that could pave way innovative approaches address challenges posed by oncology.

Language: Английский

Perineural Invasion in Cervical Cancer: A Hidden Trail for Metastasis DOI Creative Commons
G. Chen, Hao Sun, Yunxia Chen

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(14), P. 1517 - 1517

Published: July 14, 2024

Perineural invasion (PNI), the neoplastic of nerves, is an often overlooked pathological phenomenon in cervical cancer that associated with poor clinical outcomes. The occurrence PNI patients has limited promotion Type C1 surgery. Preoperative prediction can help identify suitable for However, there a lack appropriate preoperative diagnostic methods PNI, and its pathogenesis remains largely unknown. Here, we dissect neural innervation cervix, analyze molecular mechanisms underlying explore to advance identification treatment this ominous phenotype.

Language: Английский

Citations

4
Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers DOI Open Access

BINGJIE LI,

WENBO CAO,

JINJING XIAO

et al.

Biocell, Journal Year: 2024, Volume and Issue: 48(6), P. 923 - 934

Published: Jan. 1, 2024

Perineural invasion (PNI), a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread, has the capacity to extend well beyond primary site, infiltrating distant regions devoid vascular structures.PNI often heralds decrease in patient survival rates and is recognized as an indicator unfavorable prognosis across variety cancers.Despite its clinical significance, underlying molecular mechanisms PNI remain elusive, complicating development specific efficacious diagnostic therapeutic strategies.In realm cancer research, non-coding RNAs (ncRNAs) have attracted considerable attention due their multifaceted roles cancer-specific expression profiles, positioning them promising candidates for applications diagnostics, prognostics, treatment.Among various types ncRNAs, microRNAs (miRNAs), long (lncRNAs), circular (circRNAs) emerged influential players PNI.Their involvement increasingly contributing factor progression resistance.Our study synthesizes explores diverse functions ncRNAs relation cancer.This comprehensive review aims shed light on cutting-edge perspectives that could pave way innovative approaches address challenges posed by oncology.

Language: Английский

Citations

0