Comprehensive review of potential drugs with anti-pulmonary fibrosis properties

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116282 - 116282

Published: Feb. 23, 2024

Pulmonary fibrosis is a chronic and progressive lung disease characterized by the accumulation of scar tissue in lungs, which leads to impaired function reduced quality life. The prognosis for idiopathic pulmonary (IPF), most common form fibrosis, generally poor. median survival patients with IPF estimated be around 3–5 years from time diagnosis. Currently, there are two approved drugs (Pirfenidone Nintedanib) treatment IPF. However, Pirfenidone Nintedanib not able reverse or cure fibrosis. There need new pharmacological interventions that can slow halt progression This review aims provide an updated overview current future drug summarize possible targets potential anti-pulmonary drugs, providing theoretical support further clinical combination therapy development drugs.

Language: Английский

---

Breaking the Barriers: Machine-Learning-Based c-RASAR Approach for Accurate Blood–Brain Barrier Permeability Prediction

Journal of Chemical Information and Modeling, Journal Year: 2024, Volume and Issue: 64(10), P. 4298 - 4309

Published: May 3, 2024

The intricate nature of the blood–brain barrier (BBB) poses a significant challenge in predicting drug permeability, which is crucial for assessing central nervous system (CNS) efficacy and safety. This research utilizes an innovative approach, classification read-across structure–activity relationship (c-RASAR) framework, that leverages machine learning (ML) to enhance accuracy BBB permeability predictions. c-RASAR framework seamlessly integrates principles from both QSAR methodologies, underscoring need consider similarity-related aspects during development model. It note primary goal this not introduce yet another model but rather showcase refinement organic compounds through introduction approach. groundbreaking methodology aims elevate neuropharmacological implications streamline process development. In study, ML-based linear discriminant analysis (LDA) was developed using dataset 7807 compounds, encompassing BBB-permeable -nonpermeable substances sourced B3DB database (freely accessible https://github.com/theochem/B3DB), lead discovery CNS drugs. model's predictive capability then validated three external sets: one containing 276,518 natural products (NPs) LOTUS (accessible https://lotus.naturalproducts.net/download) data gap filling, comprising 13,002 drug-like/drug DrugBank (available https://go.drugbank.com/), third set 56 FDA-approved drugs assess reliability. Further diversifying arsenal, various other models were also comparison purposes. proposed emerged as powerful tool permeability. only advances understanding molecular determinants influencing provides versatile computational platform rapid assessment diverse facilitating informed decision-making design.

Language: Английский

---

Perioperative stroke

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 18, 2024

Language: Английский

---

Vascular dementia: From pathobiology to emerging perspectives

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102278 - 102278

Published: March 19, 2024

Vascular dementia (VaD) is the second most common type of dementia. VaD synonymous with ageing, and its symptoms place a significant burden on health wellbeing older people. Despite identification substantial number risk factors for VaD, pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, biogerontological imperative exists highlight modifiable lifestyle which can mitigate against developing VaD. This review will critically examine some have been revealed modulate risk. The survey commences by providing an overview putative are associated pathobiology Next, influence examined. Finally, emerging treatment avenues including epigenetics, gut microbiome, pro-longevity pharmaceuticals discussed. By drawing key evidence together, it our hope that used inform future experimental investigations in field.

Language: Английский

---

Posterity of nanoscience as lipid nanosystems for Alzheimer's disease regression

Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100701 - 100701

Published: June 17, 2023

Alzheimer's disease (AD) is a type of dementia that affects vast number people around the world, causing great deal misery and death. Evidence reveals relationship between presence soluble Aβ peptide aggregates severity in patients. The BBB (Blood Brain Barrier) key problem because it prevents therapeutics from reaching desired places. To address issue, lipid nanosystems have been employed to deliver therapeutic chemicals for anti-AD therapy precise targeted manner. applicability clinical significance (Galantamine, Nicotinamide, Quercetin, Resveratrol, Curcumin, HUPA, Rapamycin, Ibuprofen) will be discussed this review. Furthermore, implications aforementioned compounds treatment examined. Thus, review pave way researchers fashion therodiagnostics approaches based on nanomedicine overcome problems delivering molecules across blood brain barrier (BBB).

Language: Английский

---

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

MedComm, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 15, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.

Language: Английский

---

The immune-inflammatory responses on the hypothalamic-pituitary-adrenal axis and the neurovascular unit in perioperative neurocognitive disorder

Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115146 - 115146

Published: Jan. 11, 2025

Language: Английский

---

Rise in Post-resection Neutrophil-to-Lymphocyte Ratio Correlates with Decreased Survival in Glioblastoma Patients

Neuro-Oncology Advances, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 1, 2025

Neutrophil-to-lymphocyte ratio (NLR) is used in the prognostication of multiple malignancies. However, NLR value glioblastoma (GBM) controversial. This controversy may be due to unaccounted effect dexamethasone on NLR. Using retrospective data from 230 isocitrate dehydrogenase-1 (IDH) wild-type GBM patients, we studied prognostic relation treatment GBM. We retrospectively analyzed patients with and use were as dichotomous variables cutoff values 9.5 8 mg, respectively. Correlations between high NLR, well change after surgery, patient outcome measures, including post-surgical complications survival, assessed using Kaplan-Meier curves, logistic, Cox regression analyses. demonstrate this study that perioperative (≥9.5 NLR) does not associate survival (274 days, 95% confidence interval [CI] 211-337, vs. 229 CI 52-406, P = .9). positive (≥6 units) (higher postoperative relative preoperative has a significant association decreased (196 121-270, 304 223-384, .01). High average (≥8 mg) did trend associated survival. an increase surgery associates

Language: Английский

---

Postoperative Delirium and Cognitive Dysfunction After Cardiac Surgery: The Role of Inflammation and Clinical Risk Factors

Diagnostics, Journal Year: 2025, Volume and Issue: 15(7), P. 844 - 844

Published: March 26, 2025

Background/Objectives: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are prevalent neurological complications following cardiac surgery, significantly affecting patient recovery long-term outcomes, including increased risk of persistent impairment, functional decline, mortality. Understanding the underlying mechanisms factors for POD/POCD is crucial improving perioperative management. This study aimed to investigate relationship between systemic inflammation, assessed through inflammatory markers, occurrence POD POCD in patients undergoing surgery. Methods: We prospectively enrolled 88 aged 18-79 years open-heart Patients with preoperative impairment or high surgical (based on EuroSCORE SOFA scores) were excluded focus impact inflammation a relatively unselected cohort. responses (CRP, NLR, IL-6, IL-17A, SII, SIRI) measured, (CAM-ICU) (neuropsychological testing) during hospitalization at 3 months follow-up. Statistical comparisons performed who developed those did not. Results: was confirmed across cohort, significant increases CRP, SIRI. While correlational analyses changes individual markers not statistically entire exhibited higher levels IL-6 NLR 48 h postoperatively (p < 0.05). Established clinical associated included older age, prolonged cardiopulmonary bypass (CPB) duration, extended mechanical ventilation, vasopressor support blood transfusion, renal dysfunction, elevated creatine kinase (CK) lactate dehydrogenase (LDH) Ejection fraction (EF) 45% atrial fibrillation (AF) also more group. Conclusions: Our findings emphasize role response, particularly conjunction established factors, development after levels, readily measurable cost-effective may contribute identifying risk. Comprehensive management strategies targeting modifiable organ function mitigating outcomes this vulnerable population.

Language: Английский

---

The Effect of Permissive Hypercapnia during Anesthesia on Postoperative Cognitive Dysfunction

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 1358 - 1365

Published: Jan. 1, 2025

Language: Английский

---