Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(2), P. 232 - 232
Published: Feb. 14, 2024
Atherosclerosis
is
a
multifactorial
disease
of
medium
and
large
arteries,
characterized
by
the
presence
lipid-rich
plaques
lining
intima
over
time.
It
main
cause
cardiovascular
diseases
death
worldwide.
Redox
imbalance
lipid
peroxidation
could
play
key
roles
in
atherosclerosis
promoting
bundle
responses,
including
endothelial
activation,
inflammation,
foam
cell
formation.
The
oxidation
polyunsaturated
fatty
acids
generates
various
products
such
as
reactive
carbonyl
species
(RCS),
4-hydroxy
alkenals,
malondialdehyde,
acrolein.
RCS
covalently
bind
to
nucleophilic
groups
nucleic
acids,
phospholipids,
proteins,
modifying
their
structure
activity
leading
progressive
dysfunction.
Protein
lipoxidation
non-enzymatic
post-translational
modification
proteins
RCS.
Low-density
lipoprotein
(LDL)
apolipoprotein
B
(apoB)
major
role
Moreover,
oxidized
LDLs
are
source
RCS,
which
form
adducts
on
huge
number
depending
oxidative
stress
intensity,
nature
targets,
availability
detoxifying
systems.
Many
systems
affected
lipoxidation,
extracellular
matrix
components,
membranes,
cytoplasmic
cytoskeletal
transcription
factors,
other
components.
mechanisms
involved
lipoxidation-induced
vascular
dysfunction
not
fully
elucidated.
In
this
review,
we
focus
protein
during
atherogenesis.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(1), P. 587 - 587
Published: Jan. 2, 2024
Ovarian
cancer
is
one
of
the
most
dangerous
gynecologic
cancers
worldwide
and
has
a
high
fatality
rate
due
to
diagnosis
at
an
advanced
stage
disease
as
well
recurrence
occurrence
chemotherapy
resistance.
In
fact,
chemoresistance
weakens
therapeutic
effects,
worsening
outcome
this
pathology.
Solute
Carrier
Family
7
Member
11
(SLC7A11,
also
known
xCT)
functional
subunit
Xc−
system,
anionic
L-cystine/L-glutamate
antiporter
expressed
on
cell
surface.
SLC7A11
expression
significantly
upregulated
in
several
types
which
it
can
inhibit
ferroptosis
favor
proliferation,
invasion
chemoresistance.
increased
ovarian
tissues,
suggesting
possible
role
protein
target.
review,
we
provide
overview
current
literature
regarding
new
insights
modulation
evaluate
potential
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12387 - 12387
Published: Nov. 18, 2024
Cancer
is
a
multifaceted
disease
influenced
by
various
mechanisms,
including
the
generation
of
reactive
oxygen
species
(ROS),
which
have
paradoxical
role
in
both
promoting
cancer
progression
and
serving
as
targets
for
therapeutic
interventions.
At
low
concentrations,
ROS
serve
signaling
agents
that
enhance
cell
proliferation,
migration,
resistance
to
drugs.
However,
at
elevated
levels,
induce
oxidative
stress,
causing
damage
biomolecules
leading
death.
cells
developed
mechanisms
manage
activating
pathways
such
NRF2,
NF-κB,
PI3K/Akt.
This
review
explores
relationship
between
cancer,
focusing
on
death
like
apoptosis,
ferroptosis,
autophagy,
highlighting
potential
strategies
exploit
target
cells.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(6), P. 1220 - 1220
Published: March 20, 2024
Based
on
the
multifaceted
molecular
machinery
that
tightly
controls
iron
cellular
homeostasis,
this
review
delves
into
its
paradoxical,
potentially
dangerous
role
in
biological
systems,
with
a
special
focus
double-edged
sword
correlations
cancer.
Indeed,
though
is
vital
micronutrient
and
required
cofactor
participating
several
essential
cell
functions,
tendency
to
cause
oxidative
stress
can
be
related
both
cancer
risk
activation
of
death
pathways.
In
scenario,
ferroptosis
refers
an
iron-dependent
form
regulated
(RCD)
powered
by
overload
lethal
peroxides
sharing
distinctive
oxidized
phospholipid
profiles.
As
unique
pathway,
morphologically
mechanistically
different
from
other
types
programmed
involving
executioner
family
proteins.
The
accumulation
cytotoxic
lipid
encompasses
antagonism
between
execution
defense
occurring
when
ferroptosis-promoting
activities
significantly
exceed
antioxidant
defenses.
most
recent
breakthroughs
have
aroused
great
consideration
tumor
biology,
as
targeting
provide
new
tools
for
exploring
therapeutic
strategies
suppression.
Mutations
death/survival
pathway
alterations,
well
metabolic
regulations
cells,
including
propensity
generate
ROS,
are
seen
features
render
cells
unprotected
ferroptosis,
thereby
exposing
vulnerabilities
which
deserve
further
attention
regarded
targetable
cancers
limited
options.
