Regulation of bone homeostasis: signaling pathways and therapeutic targets

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 24, 2024

As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both formation by osteoblasts and resorption osteoclasts constitute reconstruction homeostasis. The equilibrium of homeostasis governed many complicated signaling pathways that weave together to form an intricate network. These coordinate the meticulous processes resorption, ensuring structural integrity vitality skeletal system. Dysregulation homeostatic regulatory network contributes development progression diseases. Significantly, imbalanced further disrupts triggers cascade reaction exacerbates disease engenders deleterious cycle. Here, we summarize influence on homeostasis, elucidating interplay crosstalk among them. Additionally, review mechanisms underpinning imbalances across diverse landscapes, highlighting current prospective therapeutic targets clinical drugs. We hope this will contribute holistic understanding molecular sustaining which are promising research shed light targeted

Language: Английский

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The influence of cell source on the senescence of human mesenchymal stem/stromal cells

Human Cell, Journal Year: 2025, Volume and Issue: 38(3)

Published: April 12, 2025

Language: Английский

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Emerging Landscape of Mesenchymal Stem Cell Senescence Mechanisms and Implications on Therapeutic Strategies

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(8), P. 2306 - 2325

Published: July 17, 2024

Mesenchymal stem cells (MSCs) hold significant promise for regenerative medicine and tissue engineering due to their unique multipotent differentiation ability immunomodulatory properties. MSC therapy is widely discussed utilized in clinical treatment. However, during both vitro expansion vivo transplantation, MSCs are prone senescence, an irreversible growth arrest characterized by morphological, gene expression, functional changes genomic regulation. The microenvironment surrounding plays a crucial role modulating senescence phenotype, influenced factors such as hypoxia, inflammation, aging status. Numerous strategies targeting have been developed, including senolytics senomorphic agents, antioxidant exosome therapies, mitochondrial transfer, niche modulation. Novel approaches addressing replicative also emerged. This paper comprehensively reviews the current molecular manifestations of addresses environmental impact on highlights potential therapeutic mitigate MSC-based therapies. These insights aim enhance efficacy understanding

Language: Английский

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Triglycerides and metabolic syndrome: from basic to mechanism – A narrative review

Archives of Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Nov. 14, 2024

The impact of triglyceride levels is important to understand the changes in metabolism and structure. With an increase obesity hyperlipidemia due diet; cardiovascular neuronal structural have been shown be more distinct.

Language: Английский

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