The Role of Platelet-Rich Plasma in Biomedicine: A Comprehensive Overview

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111705 - 111705

Published: Jan. 5, 2025

Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role clinical practice. This blood derivative, enriched platelet components, shown great potential for promoting tissue repair and regeneration. Its wide range of applications presence anti-inflammatory growth-promoting factors make it valuable tool field biomedicine. The exploration PRP settings been gaining momentum. Despite its cost-effectiveness, safety, therapeutic efficacy, widespread adoption hindered by absence consistent preparation standards standardized treatment protocols. article provides comprehensive analysis uses, physiological roles, molecular mechanisms, techniques aim is to offer thorough understanding benefits medical

Language: Английский

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 28, 2024

The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with

Language: Английский

Ubiquitination and deubiquitination: Implications for the pathogenesis and treatment of osteoarthritis

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 49, P. 156 - 166

Published: Oct. 11, 2024

Language: Английский