FGFR2 residence in primary cilia is necessary for epithelial cell signaling DOI Creative Commons
Alexandru Niţă, Sara P. Abraham, Eman Ryad Elrefaay

et al.

The Journal of Cell Biology, Journal Year: 2025, Volume and Issue: 224(7)

Published: April 21, 2025

Primary cilium projects from cells to provide a communication platform with neighboring and the surrounding environment. This is ensured by selective entry of membrane receptors signaling molecules, producing fine-tuned effective responses extracellular cues. In this study, we focused on one family fibroblast growth factor (FGFRs), their residence within cilia, its role in FGFR signaling. We show that FGFR1 FGFR2, but not FGFR3 FGFR4, localize primary cilia developing mouse tissues vitro cells. For demonstrate ciliary necessary for expression target morphogenic genes. also pathogenic FGFR2 variants have minimal presence, which can be rescued p.P253R variant associated Apert syndrome using RLY-4008 kinase inhibitor. Finally, determine molecular regulators trafficking including IFT144, BBS1, conserved T429V430 motif FGFR2.

Language: Английский

Biased signaling in drug discovery and precision medicine DOI
Ren-Lei Ji, Ya‐Xiong Tao

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108804 - 108804

Published: Feb. 1, 2025

Language: Английский

Citations

0
FGFR2 residence in primary cilia is necessary for epithelial cell signaling DOI Creative Commons
Alexandru Niţă, Sara P. Abraham, Eman Ryad Elrefaay

et al.

The Journal of Cell Biology, Journal Year: 2025, Volume and Issue: 224(7)

Published: April 21, 2025

Primary cilium projects from cells to provide a communication platform with neighboring and the surrounding environment. This is ensured by selective entry of membrane receptors signaling molecules, producing fine-tuned effective responses extracellular cues. In this study, we focused on one family fibroblast growth factor (FGFRs), their residence within cilia, its role in FGFR signaling. We show that FGFR1 FGFR2, but not FGFR3 FGFR4, localize primary cilia developing mouse tissues vitro cells. For demonstrate ciliary necessary for expression target morphogenic genes. also pathogenic FGFR2 variants have minimal presence, which can be rescued p.P253R variant associated Apert syndrome using RLY-4008 kinase inhibitor. Finally, determine molecular regulators trafficking including IFT144, BBS1, conserved T429V430 motif FGFR2.

Language: Английский

Citations

0