Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental Applications

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Vanadium is a transition metal with important industrial, technological, biological, and biomedical applications widespread in the environment living beings. The different reactions that vanadium compounds (VCs) undergo presence of proteins, nucleic acids, lipids metabolites under mild physiological conditions are reviewed. In present naturally or through anthropogenic sources, latter having an environmental impact caused by dispersion VCs atmosphere aquifers. has versatile chemistry interconvertible oxidation states, variable coordination number geometry, ability to form polyoxidovanadates various nuclearity structures. If VC added water-containing it can hydrolysis, ligand-exchange, redox, other types changes, determined speciation vanadium. Importantly, solution likely differ from introduced into system varies concentration. Here, hydrolytic ligand-exchange chemical reactions, influence pH, concentration, salt, specific solutes, biomolecules, on described. One our goals this work highlight need for assessment speciation, so beneficial toxic species might be identified mechanisms action elucidated.

Language: Английский

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Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216477 - 216477

Published: Feb. 8, 2025

Language: Английский

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Metallomics: An Essential Tool for the Study of Potential Antiparasitic Metallodrugs

ACS Omega, Journal Year: 2024, Volume and Issue: 9(14), P. 15744 - 15752

Published: March 25, 2024

Metallomics is an emerging area of omics approaches that has grown enormously in the past few years. It integrates research related to metals biological systems, symbiosis with genomics and proteomics. These can provide in-depth insights into mechanisms action potential metallodrugs, including their physiological metabolism molecular targets. Herein, we review most significant advances concerning cellular uptake subcellular distribution assays different metallodrugs activity against Trypanosma cruzi, protozoan parasite causes Chagas disease, a pressing health problem high-poverty areas Latin America. Furthermore, first multiomics metallomics, proteomics, transcriptomics for comprehensive study anti-Trypanosoma cruzi are described.

Language: Английский

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Synthesis, crystal structure, computational and solution studies of a new phosphotetradecavanadate salt. Assessment of its effect on U87 glioblastoma cells

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: 269, P. 112882 - 112882

Published: March 9, 2025

Language: Английский

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Multifunctional Organometallic Compounds Active against Infective Trypanosomes: Ru(II) Ferrocenyl Derivatives with Two Different Bioactive Ligands

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(25), P. 11667 - 11687

Published: June 11, 2024

Human African trypanosomiasis (HAT, sleeping sickness) and American (Chagas disease) are endemic zoonotic diseases caused by genomically related trypanosomatid protozoan parasites (Trypanosoma brucei Trypanosoma cruzi, respectively). Just a few old drugs available for their treatment, with most of them sharing poor safety, efficacy, pharmacokinetic profiles. Only fexinidazole has been recently incorporated into the arsenal treatment HAT. In this work, new multifunctional Ru(II) ferrocenyl compounds were rationally designed as potential agents against these pathogens including in single molecule 1,1′-bis(diphenylphosphino)ferrocene (dppf) two bioactive bidentate ligands: pyridine-2-thiolato-1-oxide ligand (mpo) polypyridyl ligands (NN). Three [Ru(mpo)(dppf)(NN)](PF6) derivatives chloride counterion synthesized fully characterized solid state solution. They showed vitro activity on bloodstream T. (EC50 = 31–160 nM) cruzi trypomastigotes 190–410 nM). Compounds lowest EC50 values when compared to whole set metal-based previously developed us. addition, several Ru good selectivity toward parasites, particularly highly proliferative form brucei. Interaction DNA generation reactive oxygen species (ROS) ruled out targets modes action compounds. Biochemical assays silico analysis led insight that they able inhibit NADH-dependent fumarate reductase from cruzi. One representative hit induced mild oxidation low molecular weight thiols The stable at least 72 h different media more lipophilic than both ligands, mpo NN. An initial assessment therapeutic efficacy one potent selective candidates, [Ru(mpo)(dppf)(bipy)]Cl, was performed using murine infection model acute trypanosomiasis. This compound lacks toxicity applied animals dose/regimen described, but unable control parasite proliferation vivo, probably because its rapid clearance or biodistribution extracellular fluids. Future studies should investigate pharmacokinetics vivo involve further research gain deeper mechanism

Language: Английский

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Vanadium 8-hydroxyquinoline derivatives in medicine: current state and future outlook

BioMetals, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

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Metal (au, Pt, Pd, Ni) Bis(dithiolene) complexes as dual-action agents combating cancer and trypanosomatid infections

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 264, P. 112788 - 112788

Published: Nov. 29, 2024

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