Harnessing the potential of bimetallic nanoparticles: Exploring a novel approach to address antimicrobial resistance

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(3)

Published: Feb. 10, 2024

Language: Английский

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Unleashing the promise of emerging nanomaterials as a sustainable platform to mitigate antimicrobial resistance

RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 13862 - 13899

Published: Jan. 1, 2024

The emergence and spread of antibiotic-resistant (AR) bacterial strains biofilm-associated diseases have heightened concerns about exploring alternative bactericidal methods. WHO estimates that at least 700 000 deaths yearly are attributable to antimicrobial resistance, number could increase 10 million annual by 2050 if appropriate measures not taken. Therefore, the increasing threat AR bacteria biofilm-related infections has created an urgent demand for scientific research identify novel therapies. Nanomaterials (NMs) emerged as a promising due their unique physicochemical properties, ongoing holds great promise developing effective NMs-based treatments viral infections. This review aims provide in-depth analysis NMs based mechanisms combat infections, particularly those caused acquired antibiotic resistance. Furthermore, this examines design features attributes can be optimized enhance efficacy agents. In addition, plant-based alternatives traditional antibiotics treating multidrug-resistant reduced toxicity compared other NMs. potential plant mediated preventing is also discussed. Overall, emphasizes importance understanding properties development strategies against bacteria.

Language: Английский

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Penicillin-binding proteins: the master builders and breakers of bacterial cell walls and its interaction with β-lactam antibiotics

Journal of Proteins and Proteomics, Journal Year: 2024, Volume and Issue: 15(2), P. 215 - 232

Published: April 6, 2024

Language: Английский

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Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

A significant global health crisis is predicted to emerge due antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic necessitates continuous therapeutic innovation as conventional treatments become increasingly ineffective. The naturally occurring antibacterial, antifungal, and antiviral compounds offer a viable alternative synthetic antibiotics. This review presents bacterial mechanisms, nanocarriers for drug delivery, plant-based nanoformulations, particularly nanoantibiotics (nAbts). Green synthesis of nanoparticles has emerged revolutionary approach, it enhances the effectiveness, specificity, transport encapsulated antimicrobials. In addition minimizing systemic side effects, these can maximize impact delivering antimicrobials directly infection site. Furthermore, combining two or more antibiotics within often exhibits synergistic enhancing effectiveness against drug-resistant bacteria. Antimicrobial agents are routinely obtained from secondary metabolites plants, including essential oils, phenols, polyphenols, alkaloids, others. Integrating antibacterial antibiotics, assisted suitable codelivery, potential solution addressing resistance. increasing their boosting immune system, this approach provides safer effective method tackling future infections.

Language: Английский

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Green Nanotechnology: Naturally Sourced Nanoparticles as Antibiofilm and Antivirulence Agents Against Infectious Diseases

International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The escalating threat of infectious diseases, exacerbated by antimicrobial resistance (AMR) and biofilm formation, necessitates innovative therapeutic strategies. This review presents a comprehensive exploration the potential nanoparticles synthesized from natural sources, including plant extracts, microbial products, marine compounds, as agents. These naturally derived demonstrated significant antibiofilm antivirulence effects, with specific examples revealing their capacity to reduce mass up 78% inhibit bacterial quorum sensing 65%. integration bioactive such polyphenols chitosan, facilitates nanoparticle stability enhances efficacy, while green synthesis protocols environmental risks. Notably, identifies silver using tea achieving 85% inhibition polymicrobial growth in vitro. Despite these promising results, challenges standardization scalability persist. study underscores transformative leveraging sourced sustainable alternatives conventional antimicrobials, offering quantitative insights for future application combating mono- infections.

Language: Английский

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Combating Antibiotic Resistance: Mechanisms, Multidrug-Resistant Pathogens, and Novel Therapeutic Approaches: An Updated Review

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 402 - 402

Published: March 12, 2025

The escalating global health crisis of antibiotic resistance, driven by the rapid emergence multidrug-resistant (MDR) bacterial pathogens, necessitates urgent and innovative countermeasures. This review comprehensively examines diverse mechanisms employed bacteria to evade action, including alterations in cell membrane permeability, efflux pump overexpression, biofilm formation, target site modifications, enzymatic degradation antibiotics. Specific focus is given transport systems such as ATP-binding cassette (ABC) transporters, resistance–nodulation–division (RND) pumps, major facilitator superfamily (MFS) multidrug toxic compound extrusion (MATE) systems, small resistance (SMR) families, proteobacterial antimicrobial (PACE) families. Additionally, explores burden MDR pathogens evaluates emerging therapeutic strategies, quorum quenching (QQ), probiotics, postbiotics, synbiotics, peptides (AMPs), stem applications, immunotherapy, antibacterial photodynamic therapy (aPDT), bacteriophage. Furthermore, this discusses novel agents, animal-venom-derived compounds nanobiotics, promising alternatives conventional interplay between clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated proteins (Cas) adaptive immunity analyzed, revealing opportunities for targeted genetic interventions. By synthesizing current advancements underscores necessity interdisciplinary collaboration among biomedical scientists, researchers, pharmaceutical industry drive development agents. Ultimately, comprehensive analysis provides a roadmap future research, emphasizing need sustainable cooperative approaches combat safeguard health.

Language: Английский

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Multifunctional SGQDs-CORM@HA nanosheets for bacterial eradication through cascade-activated “nanoknife” effect and photodynamic/CO gas therapy

Biomaterials, Journal Year: 2021, Volume and Issue: 277, P. 121084 - 121084

Published: Aug. 24, 2021

Language: Английский

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Nanoantibiotics to fight multidrug resistant infections by Gram-positive bacteria: hope or reality?

Biotechnology Advances, Journal Year: 2022, Volume and Issue: 57, P. 107948 - 107948

Published: March 23, 2022

The spread of antimicrobial resistance in Gram-positive pathogens represents a threat to human health. To counteract the current lack novel antibiotics, alternative antibacterial treatments have been increasingly investigated. This review covers last decade's developments using nanoparticles as carriers for two classes frontline antibiotics active on multidrug-resistant pathogens, i.e., glycopeptide and daptomycin. Most reviewed papers deal with vancomycin nanoformulations, being teicoplanin- daptomycin-carrying nanosystems much less Special attention is addressed nanoantibiotics used contrasting biofilm-associated infections. status art related nanoantibiotic toxicity critically reviewed.

Language: Английский

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Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections

Antibiotics, Journal Year: 2022, Volume and Issue: 11(9), P. 1208 - 1208

Published: Sept. 7, 2022

Methicillin-resistant Staphylococcus aureus (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering costs, side effects, and time duration needed for synthesis novel drugs, seeking efficient alternative approaches eradication drug-resistant bacterial agents seems to be an unmet requirement. Nickel nanoparticles (NiNPs) have been applied as prognostic therapeutic cheap various aspects biomedical sciences. Their antibacterial effects are exerted via disruption cell membrane, deformation proteins, inhibition DNA replication. NiNPs proper traits include high-level chemical stability binding affinity, ferromagnetic properties, ecofriendliness, cost-effectiveness. They outlined pleomorphic cubic structures. The combined application with CuO, ZnO, CdO enhanced their anti-MRSA effects. at approximate size around 50 nm particularly higher concentrations. conferred against MRSA than other nosocomial pathogens. green low-cost materials such albumin chitosan enhance efficacy NPs purposes.

Language: Английский

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Comparison of antibacterial activity and cytotoxicity of silver nanoparticles and silver-loaded montmorillonite and saponite

Applied Clay Science, Journal Year: 2023, Volume and Issue: 240, P. 106968 - 106968

Published: May 5, 2023

Although silver nanoparticles are known for their antibacterial activity, little research has been carried out on what synthesis method provides the most effective particles. In this study, were synthesised via chemical reduction by using nitrate as precursor, ascorbic acid reducing agent and sodium citrate stabilising agent. The solutions adjusted to several pH values employing hydroxide, citric or nitric acid. Dynamic light scattering absorption spectra in ultraviolet/visible region characterisation revealed that adjust produced more varied larger particle sizes. Then, supported montmorillonite saponite through wet impregnation ion exchange methods. Scanning electron microscopy, energy-dispersive X-ray spectroscopy transmission microscopy confirmed successfully loaded onto clay minerals. Next, activity of samples was evaluated against Escherichia coli Staphylococcus aureus determining minimum inhibitory concentrations bactericidal concentrations. free did not show any at 125 mg/L. contrast, silver-loaded obtained with a higher content displayed strongest effect. Finally, cytotoxicity determined GM07492-A cell line an XTT colorimetric assay. calculated IC50 barely toxic. Thus, minerals here promising materials high-grade safety profile.

Language: Английский

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